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Recombinant Proteins / Fusion Proteins
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ALX-522-099 Revised 27-Mar-08
LAG-3 (mouse):Fc (mouse) (recombinant)
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SYNONYMS Lymphocyte Activation Gene-3 (mouse):Fc (mouse) (recombinant)
FDC Protein (mouse):Fc (mouse) (recombinant)
CD223 (mouse):Fc (mouse) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY Dendritic Cells [DC]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-099-C050   50 µg 360.00 USD Add To Cart
ALX-522-099-C500   500 µg 1'600.00 USD Add To Cart
Product Specification
MW: ~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)
SOURCE/HOST: Produced in CHO cells. The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS.
ENDOTOXIN CONTENT: <1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human and mouse MHC class II.
BIOLOGICAL ACTIVITY: Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
APPLICATION: Flow Cytometry
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
Product Specific Literature References
LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice: P. Cappello, et al.; Cancer Res. 63, 2518 (2003) Abstract; Full Text
General Information
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4 [1]. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa) [1,2]. The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome [3]. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses [4].
BACKGROUND/TECHNICAL INFORMATION Swiss Prot link Q61790: Lymphocyte activation gene-3 protein (mouse) (Precursor)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination: F. Triebel; Trends Immunol. 24, 619 (2003) Abstract
[2] A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) Abstract
[3] Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo: C. Lienhardt, et al.; Eur. J. Immunol. 32, 1605 (2002) Abstract
[4] Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production: F. Annunziato, et al.; FASEB J. 10, 769 (1996) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • CD Proteins
 
 
ALX-201-184 Revised 01-Mar-05
LAIR-1 (22-125) (human) (recombinant)
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SYNONYMS Leukocyte-associated Ig-like Receptor 1 (22-125) (human) (recombinant)
CD305 (22-125) (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY Killer Cell Immunoglobulin-like Receptors [KIRs] / Related Products
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ALX-201-184-C100   100 µg 325.00 USD Add To Cart
Product Specification
MW: ~11.7kDa.
SOURCE/HOST: Produced in E. coli. Extracellular domain of human LAIR-1 (aa 22-125).
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride and 1mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
LAIR-1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. It features of a leader sequence, extracellular domain, transmembrane domain and a cytoplasmic region.
General Literature References
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes: L. Meyaard, et al.; Immunity 7, 283 (1997) Abstract
LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells: L. Meyaard; Curr. Top. Microbiol. Immunol. 244, 151 (1999) Abstract
Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells: L. Meyaard, et al.; J. Immunol. 162, 5800 (1999) Abstract; Full Text
Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells: J.G. Sathish, et al.; J. Immunol. 166, 1763 (2001) Abstract; Full Text
Further Categories Containing This Product:
Immunoglobulin Superfamily Cell Adhesion Molecules [IgSF CAMs] / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-131 Revised 15-May-07
LBP (human) (recombinant) (His)
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SYNONYMS Lipopolysaccharide Binding Protein (human) (recombinant) (His)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharide Binding Protein [LBP] / Related Products
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ALX-201-131-C010   10 µg 295.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 0.25mg/ml after reconstitution.
PURITY: ~90-95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 40µl distilled water.
BIOLOGICAL ACTIVITY: Mediates binding of LPS to CD14 (up to 0.2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14+ CHO transfectants (FACS)).
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Will precipitate by rapid changes of pH or temperature. Best working temperature is ice bath.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract
General Information
LBP (lipopolysaccharide binding protein) is a ~58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION Note: His-tag at the C-terminal end of the LBP has no protease site and cannot be split off.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-132 Revised 28-Jul-06
LBP (mouse) (recombinant) (His)
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SYNONYMS Lipopolysaccharide Binding Protein (mouse) (recombinant) (His)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharide Binding Protein [LBP] / Related Products
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ALX-201-132-C010   10 µg 295.00 USD Add To Cart
Product Specification
MW: ~58kDa.
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: Affinity purified
FORMULATION: Lyophilized. Contains PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.00015EU/µg protein (LAL test; Chromogenix).
RECONSTITUTION: Reconstitute with 10µl distilled water.
BIOLOGICAL ACTIVITY: Mediates binding of LPS to CD14 (up to 2µg/ml LBP mediates binding of FITC-LPS (0.5µg/ml) to CD14+ CHO transfectants (2x106/ml)).
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: LBP will precipitate upon rapid changes of pH or temperature. Keep in ice bath during application.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism: U. Grunwald, et al.; J. Immunol. 157, 4119 (1996) Abstract
General Information
LBP (lipopolysaccharide binding protein) is a 58kDa acute phase glycoprotein and binds to the lipid A portion of lipopolysaccharide (LPS) with high affinity and catalyzes the CD14 dependent cellular activation by LPS.
BACKGROUND/TECHNICAL INFORMATION His-tag at C-terminal end of LBP has no protease site and cannot be split off.
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-034 Revised 02-May-06
Leptin (human) (recombinant)
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SYNONYMS OB Gene Product (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-034-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to human serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from sterile filtered solution in 10mM sodium citrate, pH 4.0.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing 0.1% HSA or BSA.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P41159: Leptin (human) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-035 Revised 18-May-06
Leptin (mouse) (recombinant)
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SYNONYMS OB Gene Product (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-035-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to mouse serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. Studies have shown that it may also influence reproductive function. Mice with ob/ob genotype develop a form of diabetes similar to type II in humans.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link 41160: Leptin (mouse) (precursor)
AfCS Signalling Gateway link A001397: Leptin (mouse)
General Literature References
Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects: M. Maffei, et al.; Nature Med. 1, 1155 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-231 Revised 18-Mar-08
Leptin (rat) (recombinant)
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SYNONYMS OB Gene Product (rat) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-231-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to rat serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P50596: Leptin (rat) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-242 Revised 07-Aug-06
LIF (mouse) (recombinant)
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SYNONYMS Leukemia Inhibitory Factor (mouse) (recombinant)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Differentiation
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ALX-201-242-L001   1 ml 280.00 USD Add To Cart
Product Specification
MW: ~20kDa
SOURCE/HOST: Produced in E. coli.
QUANTITY: 107U
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.5% BSA. Contains no preservatives.
BIOLOGICAL ACTIVITY: Induces macrophage differentiation and proliferation of hematopoietic stem cells; maintains indifferentiated state of of embryonic stem (ES) cell cultures; inhibits proliferation of the mouse myeloid cell line M1.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells: R.L. Williams, et al.; Nature 336, 684 (1988) Abstract
A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells: C.C. Shih, et al.; Blood 95, 1957 (2000) Abstract
Leukemia inhibitory factor reduces body fat mass in ovariectomized mice: J.O. Jansson, et al.; Eur. J. Endocrinol. 154, 349 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Maintenance of ES Cells
1’000U/ml are recommended to maintain indifferentiated ES cells, R1 or E14 cells.
M1Growth Inhibition Assay:
50units/ml are defined as the concentration of LIF that induces 50% of differentiated cells in tissue culture medium.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-018 Revised 23-Nov-07
LIGHT, Soluble (human) (recombinant)
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SYNONYMS HVEML, Soluble (human) (recombinant)
TNFSF 14, Soluble (human) (recombinant)
CD258, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT / LT-betaR / DcR3 / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-018-C010   10 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~25kDa (SDS-PAGE)
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human LIGHT (aa 89-240) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human and mouse LTβR and human HVEM and DcR3.
BIOLOGICAL ACTIVITY: Increases LNCaP (prostate cancer cell) growth.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis: J. Kuai, et al.; J. Biol. Chem. 278, 14363 (2003) Abstract; Full Text
A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator: L.C. Gonzalez, et al.; PNAS 102, 1116 (2005) Abstract;