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Items 18 of 18
APO-54N-022 Revised 01-Apr-08
BAFF, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS BLyS, Soluble (human) Detection Set [For ELISA Application]
TALL-1, Soluble (human) Detection Set [For ELISA Application]
zTNF4, Soluble (human) Detection Set [For ELISA Application]
TNFSF 13B/20, Soluble (human) Detection Set [For ELISA Application]
CD257, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-022-KI01   1 Set 560.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.3ng/ml (range 0 to 30ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD)
1 vial Coating Antibody (COAT)
1 vial Detection Antibody (DET)
1 vial Goat anti-rat IgG-HRP (HRP)
APPLICATION: For the quantitative determination of soluble human BAFF from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse BAFF.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases. 
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y275: BAFF (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
BAFF Augments Certain Th1-Associated Inflammatory Responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract; Full Text
The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
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ELISA Sets
 
 
APO-54N-013 Revised 20-Jun-08
BAFF, Soluble (mouse) Detection Set [For ELISA Application]
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SYNONYMS BLyS, Soluble (mouse) Detection Set [For ELISA Application]
TALL-1, Soluble (mouse) Detection Set [For ELISA Application]
zTNF4, Soluble (mouse) Detection Set [For ELISA Application]
TNFSF 13B/20, Soluble (mouse) Detection Set [For ELISA Application]
CD257, Soluble (mouse) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-013-KI01   1 Set 1'050.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.3ng/ml (range 0 to 20ng/ml)
QUANTITY: For 4x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble mouse BAFF from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Toll-like Receptor 9-Dependent and -Independent Dendritic Cell Activation by Chromatin-Immunoglobulin G Complexes: M.W. Boule, et al.; J. Exp. Med. 199, 1631 (2004) Abstract
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling: I. Mecklenbrauker, et al.; Nature 431, 456 (2004) Abstract
BAFF Augments Certain Th1-Associated Inflammatory Responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract; Full Text
A role for B cell-activating factor of the TNF family in chemically induced autoimmunity: Y. Zheng, et al.; J. Immunol. 175, 6163 (2005) Abstract
Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding: N. Onishi, et al.; Arch. Dermatol. Res. 300, 95 (2008) Abstract
General Information
BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link : BAFF (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
Further Categories Containing This Product:
ELISA Sets
 
 
ALX-850-302 Revised 16-Nov-05
CD14, Soluble (human) Detection Set [For ELISA Application]
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-302-KI01   1 Set 690.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
FORMULATION: All reagents are stabilized with 0.01% thimerosal.
APPLICATION: For the quantitative detection of soluble human CD14 levels.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
General Information
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
ELISA Sets
 
 
ALX-850-303 Revised 16-Nov-05
CD14, Soluble (mouse) Detection Set [For ELISA Application]
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PRODUCT LINE Inflammation
PRODUCT CATEGORY CD14 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-303-KI01   1 Set 990.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
FORMULATION: All reagents are stabilized with 0.01% thimerosal.
APPLICATION: For the quantitative detection of soluble mouse CD14 levels.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
General Information
MANUFACTURER Manufactured by Biometec.
Further Categories Containing This Product:
ELISA Sets
 
 
APO-54N-040 Revised 30-Sep-08 New product
Chemerin (human) Detection Set [For ELISA Application]
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SYNONYMS RARRES2 (human) Detection Set [For ELISA Application]
Retinoic Acid Receptor Responder Protein 2 (human) Detection Set [For ELISA Application]
TIG2 (human) Detection Set [For ELISA Application]
Tazarotene-induced Gene 2 (human) Detection Set [For ELISA Application]
RAR-responsive Protein (human) Detection Set [For ELISA Application]
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-040-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.1ng/ml (range 0.156 to 10ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human chemerin from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
Chemerin (tazarotene-induced gene 2; TIG2) is a chemotactic agent that was identified as the ligand for the orphan G protein-coupled receptor ChemR23. Recently, chemerin has been shown to be expressed abundantly in adipose tissue and to function as a new adipokine [1, 2]. Chemerin potentiates insulin-stimulated glucose uptake and regulates adipogenesis and adipocyte metabolism [1].
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism: K.B. Goralski, et al.; J. Biol. Chem. 282, 28175 (2007) Abstract; Full Text
[2] Chemerin is a novel adipokine associated with obesity and metabolic syndrome: K. Bozaoglu, et al.; Endocrinology 148, 4687 (2007) Abstract
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Further Categories Containing This Product:
ELISA Sets
 
 
APO-54N-023 Revised 22-Oct-07
CTRP7 Detection Set [For ELISA Application]
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SYNONYMS C1q Tumor Necrosis Factor-α-related Protein 7 Detection Set [For ELISA Application]
C1qTNF7 Detection Set [For ELISA Application]
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-023-KI01   1 Set 560.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SENSITIVITY: 0.1ng/ml (range 0 to 10ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human and mouse CTRP7 from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
Adipose tissue functions as storage of energy and plays an active role in monitoring and controlling whole-body metabolism by secreting a number of proinflammatory adipokines, (such as leptin, resistin, tumor necrosis factor-α and interleukin-6), as well as one anti-inflammatory adipokine, adiponectin. Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle [1]. Recently, a new highly conserved family of adiponectin paralogs designated as C1q/Tumor Necrosis Factor-α-Related Proteins (CTRPs) 1-7, has been described in mouse and human [2-5]. This family of proteins exhibits similar structural and biological properties to adiponectin. The CTRPs, unlike adiponectin whose expression is restricted to adipose tissue, are widely expressed by many different adult tissues. Like adiponectin, CTRP2 rapidly induces acetyl-CoA carboxylase, and mitogen-activated protein kinase phosphorylation in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation, and CTRP7 (as well as CTRPs 1, 2 and 3) induces AMP-activated protein kinase phosphorylation. The activity of the CTRPs suggests that some members of the CTRP family of proteins could substitute for adiponectin function in vivo.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8BVD7: CTRP7 (mouse)
Swiss-Prot link Q9BXJ2: CTRP7 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Adipose tissue, adipokines, and inflammation: G. Fantuzzi; J. Allergy Clin. Immunol. 115, 911 (2005) Abstract
[2] A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004) Abstract
[3] C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen: G. Lasser, et al.; Blood 107, 423 (2006) Abstract
[4] Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes: T. Maeda, et al.; J. Cell Physiol. 206, 537 (2006) Abstract
[5] The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells: J. Weigert, et al.; FEBS Lett. 579, 5565 (2005) Abstract
Related Products
Further Categories Containing This Product:
ELISA Sets
 
 
APO-54N-025 Revised 07-Oct-08
IL-33, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS Interleukin-33, Soluble (human) Detection Set [For ELISA Application]
NF-HEV, Soluble (human) Detection Set [For ELISA Application]
IL-1F11, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Kits & Sets
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-025-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 5pg/ml (range 0 to 500pg/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble human IL-33 from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse IL-33.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Interleukin-1 (IL-1) family members, such as IL-1α/β and IL-18 play important roles in host defense, immune regulation, neuronal injury and inflammation [1, 2]. Recently, a new member of this family, IL-33, also named Nuclear Factor from High Endothelial Venules (NF-HEV) [3], has been reported to be the specific ligand for ST2 [4], an orphan receptor of the IL-1 receptor family [5]. Structurally, IL-33 is closest to IL-18, rather than IL-1β. The human IL-33 is expressed with a prodomain (aa 1-111) that is cleaved by caspase-1 to produce a 18kDa mature protein (112-270) [6]. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK athways. IL-33 is synthesized in response to cytokines such as IL-1β (but also TNFα) and plays an important role in TH2-associated immunology, by triggering an increase secretion of IL-5 and IL-13 from polarized TH2 cells. Overexpression of IL-33 in mice leads to severe pathological changes in mucosal organs.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] Differences in signaling pathways by IL-1beta and IL-18: J.K. Lee, et al. ; Proc. Natl. Acad. Sci. 101, 8815 (2004) Abstract
[2] Interleukin-1 and neuronal injury: S.M. Allan, et al.; Nat. Rev. Immunol. 5, 629 (2005) Abstract
[3] Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules: E.S. Baekkevold, et al. ; Am. J. Pathol. 163, 69 (2003) Abstract
[4] IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
[5] ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance: E.K. Brint, et al. ; Nat. Immunol. 5, 373 (2005) Abstract
[6] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases: F. Martinon & J. Tschopp; Cell 117, 561 (2004) Abstract
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • ELISA Sets
 
 
APO-54N-032 Revised 18-Jun-08
ILEI (human) Detection Set [For ELISA Application]
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SYNONYMS Interleukin-like EMT Inducer (human) Detection Set [For ELISA Application]
FAM3C (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Chemokines & Cytokines Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-032-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 200 pg/ml (range 0 to 20 ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human ILEI from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q92520: FAM3C (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu, et al.; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract
Further Categories Containing This Product:
Cancer Other Products • ELISA Sets • Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
 
 
APO-54N-017 Revised 24-Jun-08
LAG-3, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS Lymphocyte Activation Gene-3, Soluble (human) Detection Set
FDC Protein, Soluble (human) Detection Set
CD223, Soluble (human) Detection Set
PRODUCT LINE Immunology
PRODUCT CATEGORY Dendritic Cells [DC]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-017-KI01   1 Set 950.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.05ng /ml (range 0 to 4ng/ml)
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble human LAG-3 from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
Product Specific Literature References
Demonstration of antiglobulin activity in the synovial membrane of patients with rheumatoid arthritis and ankylosing spondylitis after pepsin treatment: real or artefact?: P.G. Davies, et al.; Ann. Rheum. Dis. 45, 821 (1986) Abstract
Preferential Th1 profile of T helper cell responses in X-linked (Bruton's) agammaglobulinemia: A. Amedei, et al.; Eur. J. Immunol. 31, 1927 (2001) Abstract
Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation: C. Casati, et al.; J. Immunol. 180, 3782 (2008) Abstract
General Information
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4 [1]. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa) [1,2]. The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome [3]. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses [4].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P18627: LAG-3 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[1] LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination: F. Triebel; Trends Immunol. 24, 619 (2003) Abstract
[2] A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006) Abstract
[3] Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo: C. Lienhardt, et al.; Eur. J. Immunol. 32, 1605 (2002) Abstract
[4] Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production: F. Annunziato, et al.; FASEB J. 10, 769 (1996)