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Items 18 of 18
APO-54N-035 Revised 20-Jun-08 New product
MDA5 (human) Detection Set (IntraCellular) [For ELISA Application]
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SYNONYMS Melanoma Differentiation-associated Gene 5 (human) Detection Set (IntraCellular) [For ELISA Application]
Helicard (human) Detection Set (IntraCellular) [For ELISA Application]
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-035-KI01   1 Set 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.4ng/ml (range 0 to 32ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human MDA5 in cell extracts.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description

This intracellular Detection Set is for measuring protein levels in cell lysates.  It allows to quantitatively determine:
a. Levels of MDA5
b. Interferon response since MDA5 is an interferon inducible gene
b. Virus infection response
General Information
The innate immune response to viruses is initiated upon detection of viral RNA generated during the life cycle of most viruses [1]. Recognition of the viral RNA is mediated by either the two cytoplasmic RNA helicases Retinoic acid Inducible Gene-1 (RIG-I ; Ddx58) and Melanoma Differentiation Associated gene 5 (MDA5 / Helicard; Ifih1) [2] or by Toll-like Receptor 3 (TLR3) located to an endosomal-like compartment [3]. RIG-I and MDA5 belongs to the family of RIG-I like receptor (RLR) together with the protein LGP2 whose function is still elusive [4, 5]. Upon binding to RNA, RIG-I or MDA5 binds a new mediator named Cardif, MAVS (mitochondrial antiviral signalling), IPS-1 (interferon-β promoter stimulator 1) or VISA (virus-induced signalling adapter) [6, 7]. Cardif/ MAVS/ IPS-1/ VISA then interacts with several TRAFs molecules, leading to the activation of regulatory kinases, such as TBK1, IKKε , and the IKKα/β/γ complex. These kinases activate respective transcription factors, IRF-3, IRF-7, and NF-κB that participate in the activation of IFN and other inflammatory cytokine genes. RIG-I is activated by dsRNA and 5′-ppp RNA while only poly I: C acts as a chemical agonist for MDA5. The physiological agonist of MDA5 has still to be discovered. Mda-5 is an early response gene inducible by IFN and tumor necrosis factor-α, responding predominantly to IFN-β [8].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9BYX4: MDA5 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
[8] mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract; Full Text
[6] Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
[7] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction: T. Kawai, et al.; Nat. Immunol. 6, 981 (2005) Abstract
[1] Recognition of viruses by innate immunity: O. Takeuchi & S. Akira; Immunol. Rev. 220, 214 (2007) Abstract
[4] Cytoplasmic recognition of RNA: M. Yoneyama, et al.; Adv. Drug Deliv. Rev. 60, 841 (2008) Abstract
[5] Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses: T. Venkataraman, et al.; J. Immunol. 178, 6444 (2007) Abstract
[2] MDA5/RIG-I and virus recognition: O. Takeuchi & S. Akira; Curr. Opin. Immunol. 20, 17 (2008) Abstract
[3] TLR3: Interferon induction by double-stranded RNA including poly(I:C): M. Matsumoto & T. Seya; Adv. Drug Deliv. Rev. 60, 805 (2008)
Further Categories Containing This Product:
ELISA Sets • NF-kB Pathway Other Products • Antiviral Signalling/Related Products • Caspase Recruitment Domain [CARD] Proteins/Related Products • Interferons & Interferon Receptors Other Products
 
 
ALX-804-847 Revised 19-Jun-08
Monoclonal Antibody to Cardif (human) (Adri-1)
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SYNONYMS anti-CARD Adapter Inducing Interferon-β (human) MAb (Adri-1)
anti-IPS-1 Cardif (human) MAb (Adri-1)
anti-Interferon-β Promoter Stimulator Protein 1 (human) MAb (Adri-1)
anti-MAVS (human) MAb (Adri-1)
anti-Mitochondrial Antiviral Signalling Protein (human) MAb (Adri-1)
anti-VISA (human) MAb (Adri-1)
anti-Virus-induced Signalling Adapter (human) MAb (Adri-1)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antiviral Signalling/Related Products
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ALX-804-847-C100   100 µg 370.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Adri-1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human Cardif (CARD adapter inducing interferon-β) (aa 160-450).
SPECIFICITY: Recognizes human Cardif.
APPLICATION: Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway: M.C. Michallet, et al.; Immunity 28, 651 (2008) Abstract
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-κB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons.
Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-κB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-β production.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
VISA is an adapter protein required for virus-triggered IFN-beta signaling: L.G. Xu, et al.; Mol. Cell 19, 727 (2005) Abstract
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction: T. Kawai, et al.; Nat. Immunol. 6, 981 (2005) Abstract
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3: R.B. Seth, et al.; Cell 122, 669 (2005) Abstract
CARD games between virus and host get a new player: C.L. Johnson and M. Gale, Jr.; Trends Immunol. 27, 1 (2006) Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products • Caspase Recruitment Domain [CARD] Proteins/Related Products • Polyclonal Antibodies
 
 
ALX-804-863 Revised 29-Jan-08 New product
Monoclonal Antibody to MDA5 (human) (Hely-1)
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SYNONYMS anti-Melanoma Differentiation-associated Gene 5 (human) MAb (Hely-1)
anti-Helicard (human) MAb (Hely-1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-863-C100   100 µg 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Hely-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
SPECIFICITY: Recognizes human MDA5.
APPLICATION: ELISA
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties: D.C. Kang, et al.; PNAS 99, 637 (2002) Abstract
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses: H. Kato, et al.; Nature 441, 101 (2006) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies • NF-kB Pathway Other Products • Antiviral Signalling/Related Products • Caspase Recruitment Domain [CARD] Proteins/Related Products • Interferons & Interferon Receptors Other Products
 
 
ALX-804-495 Revised 22-Dec-06
Monoclonal Antibody to Pin1 (8C10)
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SYNONYMS anti-Peptidyl-prolyl cis-trans Isomerase Pin1 MAb (8C10)
anti-PPIase Pin1 (8C10) MAb
anti-Peptidyl-prolyl cis-trans Isomerase NIMA-interacting 1 MAb (8C10)
anti-PPIase NIMA-interacting 1 (8C10) MAb
anti-Rotamase Pin1 MAb (8C10)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
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ALX-804-495-C100   100 µg 453.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Dog
CLONE: 8C10
ISOTYPE: Mouse IgG1
PURITY DETAIL: Purified from serum-free cell culture supernatant by subsequent thiophilic adsorption and size exclusion chromatography.
FORMULATION: Lyophilized from 1ml 2x PBS, 0.09% sodium azide, PEG and sucrose.
RECONSTITUTION: Reconstitute with 1ml distilled water (15min, RT).
IMMUNOGEN: Recombinant human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1.
SPECIFICITY: Recognizes human, mouse and dog Pin1. Detects a band of ~16 kDa by Western blot.
APPLICATION: Western Blot (0.5µg/ml for HRPO/ECL detection).
Recommended blocking buffer CPPT: 10mM TRIS-HCl, pH 7.4, 0.5% (w/v) casein, 1% (w/v) PEG 4'000, 1% (w/v) polyvinylpyrrolidone, 0.1% (v/v) Tween 20, 150mM sodium chloride.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted antibody is stable for 1 year when stored at -80°C. Thaw aliquots at +37°C. Thawed aliquots may be stored at +4°C for up to 3 months.
HANDLING: After reconstitution, prepare aliquots and freeze in liquid nitrogen. Avoid freeze/thaw cycles.
POSITIVE CONTROL INCLUDED: Yes (Prod. No. ALX-840-030).
General Information
Pin1, a member of the parvulin family of peptidyl-prolyl-cis-trans-isomerases (PPIases), specifically isomerizes only the phosphorylated  Ser/Thr-Pro bonds in certain proteins like Bcl-2, Cdc25C, Cdc27, p53 and Tau. Binding of Pin1 to p53 stimulates the DNA binding activity and transactivation function of p53. Pin1 also regulates the expression of cyclin D1 and is strikingly overexpressed in a subset of human tumors like breast cancer and oral squamous cell carcinoma.
Further Categories Containing This Product:
Monoclonal Antibodies • Stress & Heat Shock Proteins Other Products • p53 Other Products • Antiviral Signalling/Related Products
 
 
ALX-804-849 Revised 16-Aug-07
Monoclonal Antibody to RIG-I (Alme-1)
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SYNONYMS anti-RIG-1 MAb (Alme-1)
anti-Retinoic Acid-inducible Gene 1 Protein MAb (Alme-1)
anti-DEAD-box Protein 58 MAb (Alme-1)
anti-Probable ATP-dependent RNA Helicase DDX58 MAb (Alme-1)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY RNA Helicases/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-849-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Alme-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).
SPECIFICITY: Recognizes human and mouse RIG-I.
APPLICATION: Immunohistochemistry (paraffin sections)
Immunoprecipitation (1:100)
Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Virology. Sensing viral RNA amid your own: T. Fujita; Science 314, 935 (2006) Abstract
5’-Triphosphate RNA is the ligand for RIG-I: V. Hornung, et al.; Science 314, 994 (2006) Abstract
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates: A. Pichlmair, et al.; Science 314, 997 (2006) Abstract
Related Products
Further Categories Containing This Product:
NF-kB Pathway Other Products • Antiviral Signalling/Related Products • Caspase Recruitment Domain [CARD] Proteins/Related Products • Interferons & Interferon Receptors Other Products • Polyclonal Antibodies
 
 
ALX-804-372 Revised 22-May-08
Monoclonal Antibody to TANK-binding Kinase 1 (108A429)
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SYNONYMS anti-TBK1 MAb (108A429)
anti-NAK MAb (108A429)
anti-NF-κB-activating Kinase MAb (108A429)
anti-T2K MAb (108A429)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY IkB Kinases [IKKs]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-372-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
CLONE: 108A429
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 563-577 (YYQFKKDKAERRLAYC) of human TBK1 (TANK-binding kinase 1).
SPECIFICITY: Recognizes human, mouse, rat, dog and bovine TBK1. Detects a band of ~80kDa by Western blot.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
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Product Description
TANK-binding Kinase 1 (TBK1) is a member of the IKK family. TANK (TRAF-associated NF-κB activator) interacts with TBK1 and activates NF-κB in a kinase-dependent manner [1].
Product Specific Literature References
[1] NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase: J.L. Pomerantz & D. Baltimore; EMBO J. 18, 6694 (1999) Abstract; Full Text
[2] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway: K.A. Fitzgerald, et al.; Nat. Immunol. 4, 491 (2003) Abstract
[3] Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I: R. Sumpter, Jr., et al.; J. Virol. 79, 2689 (2005) Abstract; Full Text
[4] Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells: P. Osterlund, et al.; J. Virol. 79, 9608 (2005) Abstract
Further Categories Containing This Product:
Antiviral Signalling/Related Products • Monoclonal Antibodies
 
 
ALX-804-362 Revised 13-May-08
Monoclonal Antibody to Toll-like Receptor 3 (human) (40C1285.6)
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SYNONYMS anti-TLR3 MAb (40C1285.6)
anti-CD283 (human) MAb (40C1285.6)
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-362-C100   100 µg 293.00 USD Add To Cart
ALX-804-362B-C100 Biotin 100 µg 319.00 USD Add To Cart
ALX-804-362F-C100 FITC 100 µg 358.00 USD Add To Cart
ALX-804-362R-C100 R-PE 100 µg 397.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 40C1285.6
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: 40C1285.6: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
40C1285.6-Biotin: Liquid. In PBS containing 0.02% sodium azide.
40C1285.6-FITC: Liquid. In 10mM TRIS containing 150mM sodium chloride and 0.02% sodium azide.
40C1285.6-R-PE: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptides corresponding to human TLR3 (Toll-like receptor 3) cytoplasmic portion.
SPECIFICITY: Recognizes human TLR3.
APPLICATION: Flow Cytometry (2-5µg/106 cells for intracellular staining, for cell surface see [7])
Immunocytochemistry (see [3],[8] and [9])
Immunohistochemistry (paraffin sections) (see [4])
Immunoprecipitation (2µg/106 transfected cells)
Western Blot (1-3µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep Biotin-, FITC- and R-PE-conjugated formats at +4°C. Do not freeze. Protect from light.
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Product Specific Literature References
[1] Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol. 171, 3154 (2003) Abstract
[2] The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets: L. Wen, et al.; J. Immunol. 172, 3173 (2004) Abstract
[3] Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses: T.A. Schneeman, et al.; J. Immunol. 175, 376 (2005) Abstract
[4] Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria: E. Furrie, et al.; Immunology 115, 565 (2005) Abstract
[5] Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes: K. Li, et al.; J. Biol. Chem. 280, 16739 (2005 280, 16739 (2005) Abstract; Full Text
[6] Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto’s autoimmune thyroiditis: N. Harii, et al.; Mol. Endocrinol. 19, 1231 (2005) Abstract
[7] Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils: C.K. Wong, et al.; Am. J. Respir. Cell Mol. Biol. 37, 85 (2007) Abstract
[8] Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain: C.T. Ranjith-Kumar, et al.; J. Biol. Chem. 282, 7668 (2007) Abstract; Full Text
[9] Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells: C.T. Ranjith-Kumar, et al.; J. Biol. Chem. 282, 17696 (2007) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Antiviral Signalling/Related Products • CD Antibodies
 
 
ALX-804-474 Revised 24-Mar-05
Monoclonal Antibody to Toll-like Receptor 3 (human) (TLR3.7)
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SYNONYMS anti-TLR3 (human) MAb (TLR3.7)
anti-CD283 (human) MAb (TLR3.7)
PRODUCT LINE Inflammation
PRODUCT CATEGORY TLR Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-474-C050   50 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TLR3.7
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml.
FORMULATION: Liquid. Purified antibody in PBS containing 10% glycerol. Does not contain any preservatives.
IMMUNOGEN: Recombinant human TLR3 (Toll-like receptor 3).
SPECIFICITY: Recognizes human TLR3.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunoprecipitation
Functional Application (blocks double-stranded RNA-mediated signalling)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling: M. Matsumoto, et al.; BBRC 293, 1364 (2002) Abstract
Subcellular localization of Toll-like receptor 3 in human dendritic cells: M. Matsumoto, et al.; J. Immunol. 171, 3154 (2003) Abstract
Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains: M. Tanabe, et al.; BBRC 311, 39 (2003) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.