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ALX-380-091
Revised 21-Aug-08
17-AAG
SYNONYMS
17-(Allylamino)-17-desmethoxygeldanamycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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ALX-380-091-C100
100 µg
65.00 USD
ALX-380-091-M001
1 mg
162.00 USD
Product Specification
FORMULA:
C
31
H
43
N
3
O
8
MW:
585.7
CAS NUMBER:
75747-14-7
SOURCE/HOST:
Semisynthetic derivative from geldanamycin.
PURITY:
≥97%
APPEARANCE:
Red to dark red powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or methanol (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Potent, less toxic derivative of geldanamycin (Prod. No.
ALX-380-054
). Inhibits the essential ATPase activity of HSP90. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity.
Product Specific Literature References
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives:
R.C. Schnur, et al.; J. Med. Chem.
38
, 3806 (1995)
Abstract
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin:
T.W. Schulte & L.M. Neckers; Cancer Chemother. Pharmacol.
42
, 273 (1998)
Abstract
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone:
P.A. Clarke, et al.; Oncogene
19
, 4125 (2000)
Abstract
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts:
R. Nimmanapalli, et al.; Cancer Res.
61
, 1799 (2001)
Abstract
;
Full Text
Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells:
P.N. Munster, et al.; Cancer Res.
61
, 2945 (2001)
Abstract
;
Full Text
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin:
J. Yang, et al.; Cancer Res.
61
, 4010 (2001)
Abstract
;
Full Text
Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis:
D.M. Nguyen, et al.; Ann. Thorac. Surg.
72
, 371 (2001)
Abstract
ErbB2 degradation mediated by the co-chaperone protein CHIP:
P. Zhou, et al.; J. Biol. Chem.
278
, 13829 (2003)
Abstract
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells:
R. Villa, et al.; Carcinogenesis
24
, 851 (2003)
Abstract
Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction:
I.A. Vasilevskaya, et al.; Cancer Res.
63
, 3241 (2003)
Abstract
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors:
A. Kamal, et al.; Nature
425
, 407 (2003)
Abstract
Chaperoning oncogenes: HSP90 as a target of geldanamycin:
L. Neckers; Handb. Exp. Pharmacol. 259 (2006)
Abstract
Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress:
P. Workman, et al.; Ann. N.Y. Acad. Sci.
1113
, 202 (2007)
Abstract
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51:
Q. Yao, et al.; Clin. Cancer Res.
13
, 1591 (2007)
Abstract
;
Full Text
Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers:
R.K. Ramanathan, et al.; Clin. Cancer Res.
13
, 1769 (2007)
Abstract
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells:
P.N. Meyer, et al.; Leuk. Res.
32
, 143 (2008)
Abstract
Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model:
C.R. Williams, et al.; J. Urol.
178
, 1528 (2007)
Abstract
Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia:
A.J. Johnson, et al.; Br. J. Haematol.
139
, 837 (2007)
Abstract
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models:
U. Banerji, et al.; Cancer Chemother. Pharmacol.
62
, 769 (2008)
Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors
•
Antitumor Agents (Enzyme Inhibitors)
•
Tyrosine Kinase Inhibitors
•
Antibiotics - Other Signal Transduction Pathway Modulators
•
HSP90 / HtpG / Related Products
ALX-430-096
Revised 24-Feb-05
A77 1726
SYNONYMS
N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-430-096-M005
5 mg
45.00 USD
ALX-430-096-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
12
H
9
F
3
N
2
O
2
MW:
270.2
CAS NUMBER:
108605-62-5
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No.
ALX-430-095
). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2)
in vitro
and
in vivo
.
Product Specific Literature References
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide:
T. Mattar, et al.; FEBS Lett.
334
, 161 (1993)
Abstract
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide:
X. Xu, et al.; J. Biol. Chem.
270
, 12398 (1995)
Abstract
;
Full Text
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase:
J.P. Davis, et al.; Biochemistry
35
, 1270 (1996)
Abstract
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation:
X. Xu, et al.; Biochem. Pharmacol.
52
, 527 (1996)
Abstract
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms:
R.T. Elder, et al.; J. Immunol.
159
, 22 (1997)
Abstract
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice:
X. Xu, et al.; J. Immunol.
159
, 167 (1997)
Abstract
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression:
S.K. Manna & B.B. Aggarwal; J. Immunol.
162
, 2095 (1999)
Abstract
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner:
L.C. Hamilton, et al.; Br. J. Pharmacol.
127
, 1589 (1999)
Abstract
Further Categories Containing This Product:
Immunomodulators Other Products
•
NF-kB Pathway Inhibitors
•
COX Inhibitors
ALX-151-026
Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-026-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
39
H
57
N
7
O
14
S
MW:
880.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-151-027
Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-027-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
36
H
57
N
7
O
13
SP
MW:
858.9
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Peptides
•
Phosphoinositide 3-kinase [PI(3)K] / Related Products
ALX-350-256
Revised 03-Apr-08
(+)-Aeroplysinin-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-350-256-M001
1 mg
70.00 USD
Product Specification
FORMULA:
C
9
H
9
Br
2
NO
3
MW:
339.0
CAS NUMBER:
28656-91-9
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
CYTOTOXIC.
Product Description
Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.
Product Specific Literature References
Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba:
E. Fattorusso, et al.; J. Chem. Soc.
1
, 16 (1972)
Abstract
Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells:
M.H. Kreuter, et al.; Z. Naturforsch. [C]
44
, 680 (1989)
Abstract
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1:
M.H. Kreuter, et al.; Comp. Biochem. Physiol. B
97
, 151 (1990)
Abstract
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture:
M.H. Kreuter, et al.; Comp. Biochem. Physiol.
101C
, 183 (1992)
Abstract
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch. [C]
48
, 939 (1993)
Abstract
Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba:
A. Koulman, et al.; J. Nat. Prod.
59
, 591 (1996)
Abstract
Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge:
S. Rodriguez-Nieto, et al.; FASEB J.
16
, 261 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Natural Products with Antibiotic Activity
•
Natural Products - Antitumor Reagents
•
Natural Products for Angiogenesis Research
ALX-350-325
Revised 25-Jun-07
Altenusin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
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ALX-350-325-M001
1 mg
110.00 USD
ALX-350-325-M005
5 mg
380.00 USD
Product Specification
FORMULA:
C
15
H
14
O
6
MW:
290.3
CAS NUMBER:
31186-12-6
SOURCE/HOST:
Isolated from
Alternaria sp
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) and strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity.
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 103. Metabolites of Alternaria tenuis Auct.: Culture filtrate products:
T. Rosett, et al.; Biochem. J.
67
, 390 (1957)
Full Text
Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis:
R. Thomas; Biochem. J.
80
, 234 (1961)
Abstract
;
Full Text
Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin:
R. G. Coombe, et al.; Aus. J. Chem.
23
, 2343 (1970)
Host-specific toxins and chemical structures from alternaria species:
S. Nishimura, et al.; Ann. Rev. Phytopathol.
21
, 87 (1983)
The metabolites of Talaromycesflavus: Part 1. Metabolites of the organic extracts :
W. A. Ayer, et al.; Can. J. Chem.
68
, 2085 (1990)
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur:
S. Nakanishi, et al.; Biosci. Biotechnol. Biochem.
59
, 1333 (1995)
Abstract
Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436:
R. Uchida, et al.; J. Antibiot.
52
, 572 (1999)
Abstract
Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites:
S.B. Singh, et al.; J. Ind. Microbiol. Biotechnol.
30
, 721 (2003)
Abstract
Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites :
M. Oyama, et al.; Lett. Drug Design Discov.
1
, 24 (2004)
New penicillide derivatives isolated from Penicillium simplicissimum:
S. I. Komai, et al.; J. Nat. Med.
60
, 185 (2006)
HIV-1 integrase inhibitors: 2003-2004 update:
R. Dayam, et al.; Med. Res. Rev.
26
, 271 (2006)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Myosin Light Chain Kinase Inhibitors
•
Antibiotics - Antiviral / Anti-HIV
ALX-385-021
Revised 23-Oct-07
4'-Amino-6-hydroxyflavone
SYNONYMS
Aminogenistein
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids / Related Products
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ALX-385-021-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
15
H
11
NO
3
MW:
253.3
PURITY:
≥95%
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibitor of the p56
lck
protein-tyrosine kinase.
Product Specific Literature References
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues:
M. Cushman, et al.; J. Med. Chem.
34
, 798 (1991)
Abstract
Expression of p56lck in B-cell neoplasias:
A. Von Knethen, et al.; Leuk. Lymphoma
26
, 551 (1997)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Src Family Kinases / Related Products
•
Kinases in T Cell Signal Transduction / Related Products
ALX-380-208
Revised 03-Apr-08
Asterric acid
SYNONYMS
Dimethylosoic acid
TAN 1415A
WF 12880A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
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ALX-380-208-M001
1 mg
220.00 USD
Product Specification
FORMULA:
C
17
H
16
O
8
MW:
348.3
CAS NUMBER:
577-64-0
SOURCE/HOST:
Isolated from
Aspergillus terreus
MST-FP1370.
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Antibiotic. Inhibitor of vascular endothelial growth factor (VEGF).
Product Specific Literature References
Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol:
A. Mahmoodian and C.E. Stickings; Biochem. J.
92
, 369 (1964)
Abstract
;
Full Text
Asterric acid, a new endothelin binding inhibitor:
H. Ohashi, et al.; J. Antibiot. (Tokyo)
45
, 1684 (1992)
Abstract
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs:
H.J. Lee, et al.; J. Antibiot. (Tokyo)
55
, 552 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
VEGFs & VEGF-Rs Other Products
ALX-385-022
Revised 19-Nov-07
Baicalein
SYNONYMS
5,6,7-Trihydroxyflavone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids / Related Products
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ALX-385-022-M005
5 mg
25.00 USD
ALX-385-022-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
15
H
10
O
5
MW:
270.2
CAS NUMBER:
491-67-8
MERCK INDEX:
14:
942
PURITY:
≥97%
APPEARANCE:
Yellow to yellow-green crystalline powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.
Product Specific Literature References
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells:
J.L. Nadler, et al.; J. Clin. Invest.
80
, 1763 (1987)
Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone:
K. Ono, et al.; BBRC
160
, 982 (1989)
Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats:
K. Abe, et al.; Chem. Pharm. Bull.
38
, 209 (1990)
Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells:
H.C. Huang, et al.; Eur. J. Pharmacol.
268
, 73 (1994)
Abstract
Protective effects of baicalein against cell damage by reactive oxygen species:
D. Gao, et al.; Chem. Pharm. Bull. (Tokyo)
46
, 1383 (1998)
Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
:
S.L. Hsu, et al.; Eur. J. Pharmacol.
425
, 165 (2001)
Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes:
Y.C. Shen, et al.; Eur. J. Pharmacol.
465
, 171 (2003)
Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells:
H.Z. Lee, et al.; Anticancer Res.
25
, 959 (2005)
Abstract
Biological properties of baicalein in cardiovascular system:
Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord.
5
, 177 (2005), (Review)
Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression:
H.Y. Lin, et al.; Biochim. Biophys. Acta
1773
, 1073 (2007)
Abstract
Further Categories Containing This Product:
Leukotrienes Other Products
•
Natural Products for Angiogenesis Research
•
Tyrosine Kinase Inhibitors
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Antiviral / anti-HIV Agents
•
Lipoxygenases / Related Products
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Natural Products for Cell Cycle Research
•
Natural Products - Antioxidants
ALX-270-469
Revised 06-Jun-08
BAY 43-9006
SYNONYMS
N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
VEGFs & VEGF-Rs Other Products
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ALX-270-469-M001
1 mg
60.00 USD
ALX-270-469-M005
5 mg
240.00 USD
ALX-270-469-M025
25 mg
720.00 USD
Product Specification
FORMULA:
C
21
H
16
ClF
3
N
4
O
3
MW:
464.8
CAS NUMBER:
284461-73-0
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Broad-spectrum kinase inhibitor.
Product Specific Literature References
Sorafenib (BAY 43-9006, Nexavar((R))), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature:
L. Adnane, et al.; Meth. Enzymol.
407
, 597 (2005)
Abstract
The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress:
M. Rahmani, et al.; Mol. Cell. Biol.
27
, 5499 (2007)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
ALX-270-479
Revised 29-Feb-08
BAY 61-3606 . hydrochloride
SYNONYMS
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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Product Numbers:
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Unit Price:
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ALX-270-479-M001
