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Natural Products - Antitumor Reagents
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ALX-380-134 Revised 16-Sep-08 New product
Pyrrolcarbonyltaloside
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SYNONYMS 1-O-(Pyrrolylcarbonyl)-6-desoxy-α-L-talopyranoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-380-134-M001   1 mg 70.00 USD Add To Cart
ALX-380-134-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C11H15NO6
MW: 257.3
SOURCE/HOST: Isolated from Kitasatospora sp. (Gö M1).
PURITY: ≥98%
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Shows weak cytotoxic activity against different tumor cell lines. Has antiparasitic activity.
Product Specific Literature References
6-Deoxy-α-L-talopyranosids from Streptomyces sp.: J. Bitzer & A. Zeeck; Eur. J. Org. Chem. 2006, 3661
Further Categories Containing This Product:
Malaria / Related Products • Parasitic Diseases Other Products
 
 
ALX-350-343 Revised 14-Nov-07
Roquefortine E
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-343-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C27H31N5O2
MW: 457.6
CAS NUMBER: 871982-52-4
SOURCE/HOST: Isolated from Gymnoascus reesii MST-FP1700.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Analog of roquefortine C (Prod. No. ALX-350-342). Selective, albeit weakly active antitumor agent.
Product Specific Literature References
Roquefortine E, a diketopiperazine from an Australian isolate of Gymnoascus reessii: B. Clark, et al.; J. Nat. Prod. 68, 1661 (2005) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
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SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985) Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992) Abstract
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998) Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003) Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003) Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004) Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004) Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • T Cell Regulation Other Products • Active Substances from Fruit and Vegetables • Natural Products - Antitumor Reagents • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-159 Revised 08-May-08 New product
Septicine
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SYNONYMS 6,7-Bis(3,4-dimethoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-159-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C24H29NO4
MW: 395.5
CAS NUMBER: 42922-10-1
SOURCE/HOST: Isolated from Tylophora asthmatica.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Indolizidine alkaloid. Antitumor compound. Biogenetic precursor of the alkaloid tylophorine (Prod. No. ALX-350-154).
Product Specific Literature References
Minor alkaloids of Tylophora asthmatica. 1: Revised structure of tylophoridine: T.R. Govindachari, et al.; Tetrahedron 29, 891 (1973)
A biogenetically patterned synthesis of the indolizidine alkaloid septicine: R.B. Herbert, et al.; J.C.S. Chem. Comm. 424, 450 (1976)
Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Septicine and (-)-Tylophorine: D.L. Comins, et al.; J. Org. Chem. 62, 7435 (1997) Abstract
Indolizidine and quinolizidine alkaloids: J.P. Michael; Nat. Prod. Rep. 18, 520 (2001), Review Abstract
Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents: V.M. Sharma, et al.; Bioorg. Med. Chem. Lett. 13, 1679 (2003) Abstract
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Further Categories Containing This Product:
Adenylyl Cyclases Other Products • Alkaloids • Natural Products - Anti-inflammatory Agents
 
 
ALX-350-358 Revised 08-Apr-08
Sipholenol A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-358-C100   100 µg 140.00 USD Add To Cart
Product Specification
FORMULA: C30H52O4
MW: 476.7
SOURCE/HOST: Isolated from marine sponge Callyspongia siphonella formerly known as Siphonochalina siphonella.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Efficiently inhibits the function of P-glycoprotein (Pgp). A new reversing agent for treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Antiproliferative activity. Cytotoxic.
Product Specific Literature References
The Sipholanes: A novel group of triterpenes from the marine sponge Siphonochalina siphonella: S. Carmely & Y. Kashman; J. Org. Chem. 48, 3517 (1983) Full Text
Reversal of P-glycoprotein-mediated multidrug resistance by Sipholane triterpenoids: S. Jain, et al.; J. Nat. Prod. 70, 928 (2007) Abstract
Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells: Z. Shi, et al.; Cancer Sci. 98, 1373 (2007) Abstract
Biocatalysis of the anticancer sipholane triterpenoids: S. Jain, et al.; Planta Med. 73, 591 (2007) Abstract
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Further Categories Containing This Product:
MDR Inhibitors • P-glycoprotein [Pgp] / Related Products
 
 
ALX-350-381 Revised 05-Sep-08 New product
Sipholenone A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-381-C100   100 µg 140.00 USD Add To Cart
Product Specification
FORMULA: C30H50O4
MW: 474.7
SOURCE/HOST: Isolated from marine sponge Callyspongia siphonella formerly known as Siphonochalina siphonella.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO or 100% ethanol (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Efficiently inhibits the function of P-glycoprotein (Pgp). A new reversing agent for treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Antiproliferative activity. Cytotoxic.
Product Specific Literature References
The Sipholanes: A novel group of triterpenes from the marine sponge Siphonochalina siphonella: S. Carmely & Y. Kashman; J. Org. Chem. 48, 3517 (1983) Full Text
New triterpenoids from the Red Sea sponge Siphonochalina siphonella: Y. Kashman, et al.; J. Nat. Prod. 64, 175 (2001) Abstract
Reversal of P-glycoprotein-mediated multidrug resistance by Sipholane triterpenoids: S. Jain, et al.; J. Nat. Prod. 70, 928 (2007) Abstract
Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells: Z. Shi, et al.; Cancer Sci. 98, 1373 (2007) Abstract
Biocatalysis of the anticancer sipholane triterpenoids: S. Jain, et al.; Planta Med. 73, 591 (2007) Abstract
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Further Categories Containing This Product:
MDR Inhibitors • P-glycoprotein [Pgp] / Related Products
 
 
ALX-350-077 Revised 30-Jun-08
Swainsonine
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SYNONYMS 8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-077-MC05   0.5 mg 85.00 USD Add To Cart
ALX-350-077-M001   1 mg 148.00 USD Add To Cart
Product Specification
FORMULA: C8H15NO3
MW: 173.2
CAS NUMBER: 72741-87-8
SOURCE/HOST: Synthetic.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.
Product Specific Literature References
Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol. 98, 135 (1983) Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem. 268, 9143 (1993) Abstract; Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer 80, 87 (1999) Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res. 47, 69 (2003) Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine 14, 353 (2007) Abstract
Further Categories Containing This Product:
Alkaloids • Natural Products with Antibiotic Activity • Glycosidases / Related Products
 
 
ALX-350-356 Revised 12-Mar-08
Swinholide I
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-356-C010   10 µg 120.00 USD Add To Cart
Product Specification
FORMULA: C78H132O21
MW: 1405.9
SOURCE/HOST: Isolated from marine sponge Theonella swinhoei.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
First analog of swinholide A (Prod. No. ALX-350-088) with a hydroxylated side-chain. It shows potent cytotoxicity against the human colon adenocarcinoma cell line HCT-116 by disruption of the actin cytoskeleton. Has antifungal activity against Candida albicans.
Product Specific Literature References
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 38, 2960 (1990) Abstract
Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 42, 19 (1994) Abstract
Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments: M.R. Bubb, et al.; J. Biol. Chem. 270, 3463 (1995) Abstract; Full Text
Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts: C.A. Bewley, et al.; Experientia 52, 716 (1996) Abstract
Autoregulation of actin synthesis responds to monomeric actin levels: A. Lyubimova, et al.; J. Cell. Biochem. 65, 469 (1997) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract; Full Text
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998) Abstract
Structural basis of swinholide A binding to actin: V.A. Klenchin, et al.; Chem. Biol. 12, 287 (2005) Abstract; Full Text
Hurghadolide A and swinholide I, potent actin-microfilament disrupters from the Red Sea sponge Theonella swinhoei: D.T. Youssef & S.L. Mooberry; J. Nat. Prod. 69, 154 (2006) Abstract
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Further Categories Containing This Product:
Actin / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antifungal Agents
 
 
ALX-385-027 Revised 08-Feb-08
Tangeretin
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SYNONYMS 2-(4-Methoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benz-1-benzopyran-4-one
4’,5,6,7,8-Pentamethoxyflavone
Ponkanetin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids / Related Products
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ALX-385-027-M010   10 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C20H20O7
MW: 372.4
CAS NUMBER: 481-53-8
RTECS: DJ3102725
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Flavonoid found in the peel of citrus fruits where it provides natural resistance to fungi. Induces G1 cell cycle arrest in cancer cells. Counteracts tumor promoter-induced inhibition of intercellular communication and inhibits cell proliferation in several cancer lines. Reduces elevation of blood pressure and plasma glucose levels.
Product Specific Literature References
Nobiletin Is Main Fungistat in Tangerines Resistant to Mal Secco: A. Ben-Aziz; Science 155, 1026 (1967) Abstract
Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells: C. Chaumontet, et al.; Cancer Lett. 114, 207 (1997) Abstract
Antiproliferative activity of flavonoids on several cancer cell lines: S. Kawaii; Biosci. Biotechnol. Biochem. 63, 896 (1999) Abstract
Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation: S. Van Slambrouck, et al.; FEBS Lett. 579, 1665 (2005) Abstract
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells: K.L. Morley, et al.; Cancer Lett. 251, 168 (2007) Abstract
Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells: K.H. Chen, et al.; Biochem. Pharmacol. 73, 215 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antifungal Agents • Natural Products for Cell Cycle Research
 
 
ALX-400-053 Revised 21-Apr-08 New product
Teniposide
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SYNONYMS (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (DNA Interaction & Gene Regulation)