ALEXIS Biochemicals: Polyclonal Antibody to SCAMP2

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ALX-350-019

Revised 17-Apr-08

(+)-Brefeldin A
SYNONYMS	BFA Ascotoxin Decumbin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-019-M005		5 mg	80.00 USD
ALX-350-019-M010		10 mg	130.00 USD
ALX-350-019-M025		25 mg	270.00 USD
ALX-350-019-M050		50 mg	420.00 USD

Product Specification

FORMULA:	C₁₆H₂₄O₄
MW:	280.4
CAS NUMBER:	20350-15-6
MERCK INDEX:	14: 1369
SOURCE/HOST:	Isolated from Eupenicillium brefeldianum.
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methylene chloride or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na⁺ channels in epithelia. Induces apoptosis.

Product Specific Literature References

Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract

Further Categories Containing This Product:

Golgi Apparatus • ADP Ribosylation Factor [ARF] / Related Products • Autophagy Other Products • Collagen / Related Products • Na+ Channels • Antitumor Antibiotics • Antitumor Agents (Apoptosis Inducers) • Antibiotics - Antiviral / Anti-HIV • Antibiotics - Antifungal

ALX-350-240

Revised 05-Dec-07

Ilimaquinone
SYNONYMS	3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-240-C100		100 µg	140.00 USD

Product Specification

FORMULA:	C₂₂H₃₀O₄
MW:	358.5
CAS NUMBER:	71678-03-0
PURITY:	≥98%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Displays antimicrobial, anti-HIV and anti-inflammatory properties. Induces reversible breakdown of Golgi membranes. Inhibits the association of β-COP and ADP-ribosylation factor to Golgi membranes. Interacts with methylation enzymes. Shows anticancer activity.

Product Specific Literature References

R.T. Luibrand, et al.; Tetrahedron 35, 609 (1979)
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone: P.A. Takizawa, et al.; Cell 73, 1079 (1993) Abstract
Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion: H.S. Radeke, et al.; Chem. Biol. 6, 639 (1999) Abstract
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport: V. Cruciani, et al.; Exp. Cell Res. 287, 130 (2003) Abstract
Natural products with anti-HIV activity from marine organisms: L.A. Tziveleka, et al.; Curr. Top. Med. Chem. 3, 1512 (2003), Review Abstract
Interaction of the smooth endoplasmic reticulum and mitochondria: J.G. Goetz & I.R. Nabi; Biochem. Soc. Trans. 34, 370 (2006), Review Abstract
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway: P.H. Lu, et al.; Eur. J. Pharmacol. 556, 45 (2007) Abstract

Further Categories Containing This Product:

ADP Ribosylation Factor [ARF] / Related Products • Golgi Apparatus • PRMTs, Mono- & Dimethylarginine / Related Products • Natural Products - Chemopreventive Agents • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Anti-inflammatory Agents

ALX-804-604

Revised 31-Oct-06

Monoclonal Antibody to CLIMP-63 (G1/296)
SYNONYMS	anti-ER Protein p63 MAb (G1/296) anti-Cytoskeleton-linking Membrane Protein of 63kDa MAb (G1/296)
PRODUCT LINE	Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY	ER-Golgi Intermediate Compartment [ERGIC] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-604-C100		100 µg	340.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Monkey
CLONE:	G1/296
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	>95%
PURITY DETAIL:	Protein G-affinity purified and gel filtrated (FPLC).
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN:	Human CLIMP-63 (cytoskeleton-linking membrane protein of 63kDa) from Caco-2 cells golgi membrane fraction.
SPECIFICITY:	Recognizes human CLIMP-63. Cross-reacts with monkey CLIMP-63.
APPLICATION:	ELISA Flow Cytometry Immunocytochemistry (1:1’000) Immunohistochemistry (frozen sections) Immunoprecipitation (2µl) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Description

The cytoskeleton-linking membrane protein of 62kDa (CLIMP-63) is a marker for the reticular subdomain of the rough endoplasmatic reticulum (ER) and is excluded from the outer nuclear membrane. Concentration of CLIMP-63 into patches may enhance microtubule binding on the cytosolic side and contribute to ER morphology by the formation of a protein scaffold in the lumen of the ER, linking the rough ER to microtubules.

Product Specific Literature References

Characterization of a novel 63 kDa membrane protein. Implications for the organization of the ER-to-Golgi pathway: A. Schweizer, et al.; J. Cell Sci. 104, 671 (1993) Abstract; Full Text
A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein: A. Schweizer, et al.; J. Cell Sci. 104, 685 (1993) Abstract; Full Text
Retention of p63 in an ER-Golgi intermediate compartment depends on the presence of all three of its domains and on its ability to form oligomers: A. Schweizer, et al.; J. Cell Biol. 126, 25 (1994) Abstract; Full Text
Reassessment of the subcellular localization of p63: A. Schweizer, et al.; J. Cell Sci. 108, 2477 (1995) Abstract; Full Text
A novel direct interaction of endoplasmic reticulum with microtubules: D.R. Klopfenstein, et al.; EMBO J. 17, 6168 (1998) Abstract; Full Text
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment: D.R. Klopfenstein, et al.; J. Cell Biol. 153, 1287 (2001) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text

Further Categories Containing This Product:

Golgi Apparatus • Monoclonal Antibodies

ALX-804-600

Revised 19-Jun-08

Monoclonal Antibody to Giantin (G1/133)
SYNONYMS	anti-Macrogolgin MAb (G1/133) anti-Golgi Complex-associated 372kDa Protein MAb (G1/133) anti-GCP372 MAb (G1/133)
PRODUCT LINE	Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY	Golgi Apparatus

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-600-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Goat Sheep Dog Pig Monkey Others
CLONE:	G1/133
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	>95%
PURITY DETAIL:	Affinity purified (HYDRA column) and gel filtrated (FPLC).
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN:	Giantin from Caco-2 cell Golgi membrane fraction.
SPECIFICITY:	Recognizes monkey, mammalian and avian giantin.
APPLICATION:	ELISA Flow Cytometry Immunocytochemistry (1:1’000) Immunohistochemistry (frozen sections) Immunoprecipitation (2µl) Note: Not recommended for Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Description

Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. Giantin plays also a role in docking COPI vesicles to Golgi membranes. It is speculated that after mitosis giantin aids in guiding vesiculated Golgi membranes to the microtubule organizing center to reform a new Golgi apparatus.

Product Specific Literature References

Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa: A.D. Linstedt and H.P. Hauri; Mol. Biol. Cell 4, 679 (1993) Abstract; Full Text
Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway: C. Itin, et al.; J. Cell Biol. 131, 57 (1995) Abstract; Full Text
Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme: F. Vollenweider, et al.; J. Cell Biol. 142, 377 (1998) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text
Capturing protein interactions in the secretory pathway of living cells: B. Nyfeler, et al.; PNAS 102, 6350 (2005) Abstract; Full Text
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi: S. Mitrovic, et al.; Mol. Biol. Cell 19, 1976 (2008) Abstract

Further Categories Containing This Product:

Cell Structure and Organelle Markers • Monoclonal Antibodies

ALX-804-603

Revised 31-Aug-07

Monoclonal Antibody to GPP130 (A1/118)
SYNONYMS	anti-Golgi Phosphoprotein of 130kDa MAb (A1/118) anti-GIMPc MAb (A1/118) anti-cis-Golgi Integral Membrane Protein MAb (A1/118)
PRODUCT LINE	Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY	Golgi Apparatus

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-603-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Monkey
CLONE:	A1/118
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml after reconstitution.
PURITY DETAIL:	Affinity purified (HYDRA column) and gel filtrated (FPLC).
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN:	GPP130 (Golgi phosphoprotein of 130kDa) from Vero monkey cells.
SPECIFICITY:	Recognizes monkey GPP130. Cross-reacts with human GPP130.
APPLICATION:	ELISA Flow Cytometry Immunocytochemistry (1:1’000) Immunohistochemistry (frozen sections) Immunoprecipitation (2µl) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Images

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Product Description

The transmembrane protein GPP130 is localized to the cis-Golgi, where it is targeted by virtue of its lumenal coiled-coil domain and mediates trafficking in the late endosome-bypass pathway. GPP130 continuously recycles between early Golgi and distal compartments.

Product Specific Literature References

Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein: A.D. Linstedt, et al.; Mol. Biol. Cell 8, 1073 (1997) Abstract; Full Text
Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme: F. Vollenweider, et al.; J. Cell Biol. 142, 377 (1998) Abstract; Full Text
The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment: J. Klumperman, et al.; J. Cell Sci. 111, 3411 (1998) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text

Further Categories Containing This Product:

Monoclonal Antibodies

ALX-804-095

Revised 09-Aug-07

Monoclonal Antibody to trans-Golgi Network 38 (rat) (2F7.1)
SYNONYMS	anti-TGN38 (rat) MAb (2F7.1)
PRODUCT LINE	Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY	Golgi Apparatus

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-095-R100		100 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Rat
CLONE:	2F7.1
ISOTYPE:	Mouse IgG1
FORMULATION:	Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 1-17 (L¹PSASKPNNTS SENNPP¹⁷) of N-terminal rat TGN38 (trans-Golgi network 38).
SPECIFICITY:	Recognizes the luminal domain of rat TGN38. Detects a band of ~38kDa by Western blot, representing deglycosylated TGN38. Under normal Western blot conditions detects a band of ~85-95kDa depending on cell type.
APPLICATION:	Flow Cytometry Immunocytochemistry (1:1'000) Western Blot (1:500)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Okadaic acid treatment leads to fragmentation of the trans-Golgi network and an increase of TGN38 at the cell surface: M. Horn & G. Banting; Biochem. J. 301, 69 (1994) Abstract
Lumenal and transmembrane domains play a role in sorting type I membrane proteins on endocytic pathways: B.J. Reaves, et al.; Mol. Biol. Cell 9, 1107 (1998) Abstract; Full Text
Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain: E.P. Roquemore and G. Banting; Mol. Biol. Cell 9, 2125 (1998) Abstract; Full Text
GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat: K. Kawamoto, et al.; Traffic 3, 483 (2002) Abstract; Full Text
Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology: S. Kupzig, et al.; Traffic 4, 694 (2003) Abstract; Full Text

General Information

The trans-Golgi network (TGN) is part of the secretory pathway of eukaryotic cells which is distinct from the Golgi stack.The TGN is important in the later stages of protein secretion where it seems to play a key role in the sorting and targeting of secreted proteins to the correct destination. Brefeldin A, Prod. No. ALX-350-019 causes the contents of the Golgi stack to be redistributed into the endoplasmatic reticulum while the TGN collapse upon the microtubule organizing center. This makes immunofluorescence detection of TGN38, following Brefeldin A treatment, a useful tool for the discrimination of the TGN from the Golgi stack.

Further Categories Containing This Product:

Monoclonal Antibodies

ALX-350-086

Revised 08-Apr-08

Nordihydroguaiaretic acid
SYNONYMS	NDGA 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-086-G001		1 g	62.00 USD

Product Specification

FORMULA:	C₁₈H₂₂O₄
MW:	302.4
CAS NUMBER:	500-38-9
MERCK INDEX:	14: 6693
SOURCE/HOST:	Synthetic.
PURITY:	≥95%
APPEARANCE:	Crystalline powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol or acetone; slightly soluble in hot water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Antioxidant and antineoplastic. Lipoxygenase inhibitor. Stimulates the rapid retrograde movement of both Golgi stacks and the trans-Golgi network to the endoplasmatic reticulum (ER). Displays pleiotropic effects on cells, which include apoptosis, cell proliferation, differentiation and chemotaxis. Anticancer agent.

Product Specific Literature References

Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid: M. Pavani, et al.; Biochem. Pharmacol. 48, 1935 (1994) Abstract
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 273, 3068 (1998) Abstract; Full Text
Effect of nordihydroguaiaretic acid on the secretion of lipoprotein lipase: S.M. Kim, et al.; J. Biochem. Mol. Biol. 35, 518 (2002) Abstract; Full Text
Mechanisms underlying the activation of large conductance Ca2+-activated K+ channels by nordihydroguaiaretic acid: H. Yamamura, et al.; Jpn. J. Pharmacol. 89, 53 (2002) Abstract
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid: T. Fujiwara, et al.; BBRC 301, 927 (2003) Abstract
Stepwise dissection of the intracellular fate of cationic cell-penetrating peptides: R. Fischer, et al.; J. Biol. Chem. 279, 12625 (2004) Abstract; Full Text
The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling: C.A. Culver, et al.; Life Sci. 77, 2457 (2005) Abstract
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs: E. Floriano-Sanchez, et al.; Free Radic. Res. 40, 523 (2006) Abstract
Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells: K. Arasaki, et al.; Mol. Pharmacol. 71, 454 (2007) Abstract
Protective role of nordihydroguaiaretic acid (NDGA) against the genotoxic damage induced by ethynodiol diacetate in human lymphocytes in vitro: Y.H. Siddique, et al.; J. Environ. Biol. 28, 279 (2007) Abstract

Further Categories Containing This Product:

Golgi Apparatus • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antioxidants • Natural Products - Antitumor Reagents • Lipoxygenases / Related Products

ALX-210-884

Revised 03-Jun-05

Polyclonal Antibody to α-COP
SYNONYMS	anti-α-Coat Protein PAb
PRODUCT LINE	Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY	Golgi Apparatus

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-884-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Rat
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 1-19 (M¹LTKFETKSARVK GLSFHP¹⁹) of rat α-COP (coat-protein (α subunit)).
SPECIFICITY:	Recognizes human and rat α-COP. Detects bands of ~140kDa (representing α-COP) and ~100kDa (unidentified) by Western blot.
APPLICATION:	Immunocytochemistry: (3µg/ml) Immunocytochemical staining results in α-COP localization to the Golgi complex and to distinct vesicular structures scattered throughout the cytoplasm. Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-153-057.

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