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ALX-210-849
Revised 25-Jan-07
Polyclonal Antibody to CCR10 (human)
SYNONYMS
anti-C-C Chemokine Receptor 10 (human) PAb
anti-G-Protein Coupled Receptor 2 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-849-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 9-31 (V
9
SWGHYSGDEE
DAYSAEPLPELC
31
) of human CCR10 (C-C chemokine receptor 10; G-protein coupled receptor 2).
SPECIFICITY:
Recognizes human CCR10.
APPLICATION:
Flow Cytometry (2-5µg/50µl per 2x10
5
cells)
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250)
Western Blot (1:1’000)
QUALITY CONTROL:
Immunohistochemistry on human spleen.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-051
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-840
Revised 08-Oct-07
Polyclonal Antibody to CCR10 (human)
SYNONYMS
anti-C-C Chemokine Receptor 10 (human) PAb
anti-G-Protein Coupled Receptor 2 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-840-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 350-362 (S
350
APTETHSLSWDN
362
) of human CCR10 (C-C chemokine receptor 10; G-protein coupled receptor 2). This sequence is completely conserved in mouse CCR10.
SPECIFICITY:
Recognizes human CCR10. Detects a band of ~40kDa by Western blot.
APPLICATION:
Flow Cytometry (see [2])
Immunohistochemistry (see [1])
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Expression of the T-helper 2-specific chemokine receptor CCR4 on CCR10-positive lymphocytes in atopic dermatitis skin but not in psoriasis skin:
C. Vestergaard, et al.; Br. J. Dermatol.
149
, 457 (2003)
Abstract
[2]
Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10:
H. Moed, et al.; Br. J. Dermatol.
151
, 32 (2004)
Abstract
[3]
Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle:
H. Sell, et al.; Endocrinology
147
, 2458 (2006)
Abstract
;
Full Text
[4]
In vitro and in vivo studies on CCR10 regulation by Annexin A1:
F.C. Rodrigues-Lisoni, et al.; FEBS Lett.
580
, 1431 (2006)
Abstract
General Literature References
Cloning, expression, and chromosomal mapping of a novel human CC- chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3 :
J.A. Bonini, et al.; DNA Cell Biol.
16
, 1249 (1997)
Abstract
Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6 :
R.J. Nibbs, et al.; J. Biol. Chem.
272
, 32078 (1997)
Abstract
;
Full Text
Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK :
J. Gosling, et al.; J. Immunol.
164
, 2851 (2000)
Abstract
Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine
:
D.I. Jarmin, et al.; J. Immunol.
164
, 3460 (2000)
Abstract
International union of pharmacology. XXII. Nomenclature for chemokine receptors :
P.M. Murphy, et al.; Pharmacol. Rev.
52
, 145 (2000), (Review)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-848
Revised 25-Jan-07
Polyclonal Antibody to CCR10 (mouse)
SYNONYMS
anti-C-C Chemokine Receptor 10 (mouse) PAb
anti-G-Protein Coupled Receptor 2 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-848-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 4-31 (K
4
PTEQVSWGLYS
GYDEEAYSVGPLPELC
31
) of mouse CCR10 (C-C chemokine receptor 10; G-protein coupled receptor 2).
SPECIFICITY:
Recognizes mouse CCR10.
APPLICATION:
Flow Cytometry (1:25)
Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1’000)
QUALITY CONTROL:
Immunohistochemistry on mouse lymph nodes or small intestine.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod No.
ALX-153-050
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-828
Revised 23-Jun-08
Polyclonal Antibody to CD3ζ (22-30)
SYNONYMS
anti-CD247 (22-30) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD3 - Marker for T Cells
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-828-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 22-30 (Q
22
SFGLLDPK
30
) of human CD3ζ.
SPECIFICITY:
Recognizes human and mouse CD3ζ. Cross-reacts with CD3η.
For the detection of the cytoplasmic domain of CD3ζ, we recommend Prod. No.
ALX-210-829
.
APPLICATION:
Immunoprecipitation
(can be used with the detergent NP-40, but not with digitonin)
Western Blot
(1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
The Signaling Adaptor Protein CD3ζ Is a Negative Regulator of Dendrite Development in Young Neurons:
SJ. Baudouin, et al.; Mol. Biol. Cell
6
, 2444 (2008)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-829
Revised 22-Feb-05
Polyclonal Antibody to CD3ζ (154-164)
SYNONYMS
anti-CD247 (154-164) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD3 - Marker for T Cells
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-829-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 154-164 (D
154
ALHMQALPPR
164
) of human CD3ζ.
SPECIFICITY:
Recognizes human and mouse CD3ζ. Does not cross-react with CD3η.
For the detection of the extracellular domain of CD3ζ
we recommend Prod. No.
ALX-210-828
.
APPLICATION:
Immunoprecipitation
(can be used with either NP-40 or digitonin as detergent)
Western Blot
(1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface
:
P. Isomaki, et al.; J. Immunol.
166
, 5495 (2001)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-210-826
Revised 08-Dec-04
Polyclonal Antibody to CD27 (mouse)
SYNONYMS
anti-TNFRSF 7 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CD27 & CD27L [CD70] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-826-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. 100µg of purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse CD27 corresponding to aa 208-250 (H
208
GPNEDRQAVPEEPCPYSCPREEEGSAIPIQEDYRKPEPAFYP
250
) of the cytoplasmic domain.
SPECIFICITY:
Recognizes mouse CD27.
APPLICATION:
Immunoprecipitation
Western Blot (recommended starting dilution: 1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2:
L.A. Gravestein, et al.; Eur. J. Immunol.
28
, 2208 (1998)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
CD Antibodies
ALX-215-043
Revised 20-Oct-06
Polyclonal Antibody to CD39 (mouse)
SYNONYMS
anti-Ectonucleoside Triphosphate Diphosphohydrolase 1 (mouse) PAb
anti-NTPDase 1 (mouse) PAb
anti-ENTPD1 (mouse) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-043-R100
100 µl
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse CD39.
SPECIFICITY:
Recognizes mouse CD39.
APPLICATION:
Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Literature References
Nucleotides and cd39: principal modulatory players in hemostasis and thrombosis:
H. Zimmermann; Nat. Med.
5
, 987 (1999), (Comment)
Abstract
The skinny on CD39 in immunity and inflammation:
R.D. Granstein; Nat. Med.
8
, 336 (2002), (Comment)
Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation:
S.C. Robson, et al.; Semin. Thromb. Hemost.
31
, 217 (2005), (Review)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-045
Revised 20-Oct-06
Polyclonal Antibody to CD39L1 (human)
SYNONYMS
anti-Ectonucleoside Triphosphate Diphosphohydrolase 2 (human) PAb
anti-NTPDase 2 (human) PAb
anti-ENTPD2 (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-045-R100
100 µl
330.00 USD
Product Specification
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of human CD39L1.
SPECIFICITY:
Recognizes human CD39L1.
APPLICATION:
Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Literature References
Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system:
N. Braun, et al.; Glia
45
, 124 (2004)
Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation:
S.C. Robson, et al.; Semin. Thromb. Hemost.
31
, 217 (2005), (Review)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-044
Revised 20-Oct-06
Polyclonal Antibody to CD39L1 (mouse)
SYNONYMS
anti-Ectonucleoside Triphosphate Diphosphohydrolase 2 (mouse) PAb
anti-NTPDase 2 (mouse) PAb
anti-ENTPD2 (mouse) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-044-R100
100 µl
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse CD39L1.
SPECIFICITY:
Recognizes mouse CD39L1.
APPLICATION:
Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Literature References
Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system:
N. Braun, et al.; Glia
45
, 124 (2004)
Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation:
S.C. Robson, et al.; Semin. Thromb. Hemost.
31
, 217 (2005), (Review)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-046
Revised 27-Dec-06
Polyclonal Antibody to CD39L2 (mouse)
SYNONYMS
anti-Ectonucleoside Triphosphate Diphosphohydrolase 6 (mouse) PAb
anti-NTPDase 6 (mouse) PAb
anti-ENTPD6 (mouse) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-046-R100
100 µl
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse CD39L2.
SPECIFICITY:
Recognizes mouse CD39L2.
APPLICATION:
Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Literature References
Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function:
V.V. Ivanenkov, et al.; Biochemistry
42
, 11726 (2003)
Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation:
S.C. Robson, et al.; Semin. Thromb. Hemost.
31
, 217 (2005), (Review)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-047
Revised 20-Oct-06
Polyclonal Antibody to CD39L4 (human)
SYNONYMS
anti-Ectonucleoside Triphosphate Diphosphohydrolase 5 (human) PAb
anti-NTPDase 5 (human) PAb
anti-ENTPD5 (human) PAb
anti-PCPH (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-047-R100
100 µl
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of human CD39L4.
SPECIFICITY:
Recognizes human CD39L4.
APPLICATION:
Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
Immunoprecipitation (1:100-1:400)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Information
BACKGROUND/TECHNICAL INFORMATION
Since CD39L4 is secreted, cells need to be permeabilized to visualize CD39L4 in transit through the ER and Golgi.
General Literature References
Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene:
J.G. Paez, et al.; Int. J. Oncol.
19
, 1249 (2001)
Abstract
Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase:
D.M. Murphy-Piedmonte, et al.; Biochim. Biophys. Acta
1747
, 251 (2005)
Abstract
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation:
S.C. Robson, et al.; Semin. Thromb. Hemost.
31
, 217 (2005), (Review)
Abstract
PCPH expression is an early event in the development of testicular germ cell tumors:
J. Regadera, et al.; Int. J. Oncol.
28
, 595 (2006)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-048
Revised 27-Dec-06
Polyclonal Antibody to CD39L4 (mouse)
SYNONYMS
