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Neurobiology
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ALX-151-008 Revised 23-Oct-07
β-Amyloid (25-35)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY beta-Amyloid Peptides
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-008-P001   1 mg* 120.00 USD Add To Cart
ALX-151-008-P005   5 mg* 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
FORMULA: C45H81N13O14S
MW: 1060.3
QUANTITY: *Sold as net peptide weight.
PEPTIDE CONTENT: 70-90%
PURITY: ≥99% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides: B.A. Yankner, et al.; Science 250, 279 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-009 Revised 13-Aug-02
β-Amyloid (10-20)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY beta-Amyloid Peptides
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ALX-151-009-P001   1 mg* 90.00 USD Add To Cart
ALX-151-009-P005   5 mg* 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH
FORMULA: C71H99N17O16
MW: 1446.7
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor: K. Miyazaki, et al.; Nature 362, 839 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-011 Revised 13-Jan-05
β-Amyloid/A4 Protein Precursor [APP] (328-332)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY beta-Amyloid Peptides
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ALX-151-011-P001   1 mg* 90.00 USD Add To Cart
ALX-151-011-P005   5 mg* 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Glu-Arg-Met-Ser-OH
FORMULA: C25H47N11O9S
MW: 677.8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥96%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in TFA/water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Active domain of the amyloid β/A4 protein precursor (APP) that promotes fibroblast growth.
Product Specific Literature References
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth: H. Ninomiya, et al.; J. Cell. Biol. 121, 879 (1993) Abstract
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Peptides
 
 
ALX-151-013 Revised 05-Dec-06
Apamin
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-151-013-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15)
FORMULA: C131H131N31O24S4
MW: 2027.3
CAS NUMBER: 24345-16-2
MERCK INDEX: 14: 725
RTECS: CD6899900
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in 0.05M acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
Product Specific Literature References
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
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Peptides
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NAALADase / Related Products • Peptides
 
 
ALX-151-024 Revised 03-Mar-05
H-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-151-024-M001   1 mg 95.00 USD Add To Cart
ALX-151-024-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C39H70N18O11
MW: 967.1
PURITY: ≥98%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for myelin basic protein kinase (p44mpk) and for MAP kinase (MAPK/ERK).
Product Specific Literature References
Identification of the sites in myelin basic protein that are phosphorylated by meiosis-activated protein kinase p44mpk: J.S. Sanghera, et al.; FEBS Lett. 273, 223 (1990) Abstract
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase: I. Clark-Lewis, et al.; J. Biol. Chem. 266, 15180 (1991) Abstract; Full Text
M. Daeipour, et al.; J. Immunol. 150, 4743 (1993) Abstract
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Peptides
 
 
ALX-151-026 Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-026-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C39H57N7O14S
MW: 880.0
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-151-027 Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-151-027-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C36H57N7O13SP
MW: 858.9
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
Further Categories Containing This Product:
Peptides • Phosphoinositide 3-kinase [PI(3)K] / Related Products
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-152-018 Revised 20-Aug-02
Bombesin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-152-018-P001   1 mg* 40.00 USD Add To Cart
ALX-152-018-P005   5 mg* 160.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
FORMULA: C71H110N24O18S
MW: 1619.9
CAS NUMBER: 31362-50-2
MERCK INDEX: 14: 1329
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: While lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-152-031 Revised 17-Nov-08
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
PEPTIDE CONTENT: ≥85%
PURITY: ≥98% (HPLC)
APPEARANCE: