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ALX-210-338
Revised 10-Dec-07
Polyclonal Antibody to Histone Deacetylase 4 (human) (CT)
SYNONYMS
anti-HDAC4 (human) (CT) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-338-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1071-1084 (K
1071
RPDEEPMEEEPPL
1084
) of human HDAC4 (histone deacetylase 4).
SPECIFICITY:
Recognizes human HDAC4. Detects a band of ~140kDa by Western blot. Also detects a band of ~110kDa which may correspond to protein degradation product.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-158-009
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-339
Revised 12-Jan-05
Polyclonal Antibody to Histone Deacetylase 4 (NT)
SYNONYMS
anti-HDAC4 (NT) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-339-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. Purified IgG in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 194-209 of human HDAC4 (histone deacetylase 4).
SPECIFICITY:
Recognizes human and mouse HDAC4. Detects a band of ~140kDa by Western blot.
APPLICATION:
Western Blot (0.5-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-340
Revised 12-Jan-05
Polyclonal Antibody to Histone Deacetylase 5
SYNONYMS
anti-HDAC5 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-340-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. Purified IgG in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 572-587 of human HDAC5 (histone deacetylase 5).
SPECIFICITY:
Recognizes human and mouse HDAC5. Detects a band of`~120kDa.
APPLICATION:
Western blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-341
Revised 18-Jan-07
Polyclonal Antibody to Histone Deacetylase 6
SYNONYMS
anti-HDAC6 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-341-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-16 of human HDAC6 (histone deacetylase 6).
SPECIFICITY:
Recognizes human and mouse HDAC6. Detects a band of ~134kDa by Western blot.
APPLICATION:
Immunoprecipitation, Chromatin Immunoprecipitation (see [1])
Western Blot (2µg/ml).
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters:
C. Imbriano, et al.; Mol. Cell. Biol.
25
, 3737 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-352
Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-352-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:
Recognizes mouse MDA5.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation:
M. Kovacsovics, et al.; Curr. Biol.
12
, 838 (2002)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Related Products
ALX-210-935
Polyclonal Antibody to MDA5 (human) (AT113)
ALX-804-863
Monoclonal Antibody to MDA5 (human) (Hely-1)
APO-54N-035
MDA5 (human) (IntraCellular) Detection Set [For ELISA Application]
APO-54N-039
MDA5 (human) (IntraCellular) ELISA Kit
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Antiviral Signalling / Related Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Interferons & Interferon Receptors Other Products
•
Polyclonal Antibodies
ALX-210-361
Revised 26-Feb-07
Polyclonal Antibody to PPARα (mouse) (phosphorylated) (pSer12)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor α (mouse (phosphorylated) (pSer
12
) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-361-C100
100 µg
385.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS contanining 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 8-19 (I
8
CPLpSPLEADDL
19
) of mouse PPARα (peroxisome proliferator activated receptor α) phosphorylated at Ser
12
.
SPECIFICITY:
Recognizes mouse PPARα phosphorylated at Ser
12
. Detects a band of ~52 kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-055
.
Product Specific Literature References
MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response
:
M.W. Kilgore, et al.; Mol. Cell Endocrinol.
129
, 229 (1997)
Abstract
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
:
R.M. Lavinsky, et al.; PNAS
95
, 2920 (1998)
Abstract
;
Full Text
Related Products
ALX-165-055
Blocking Peptide for PAb to PPARα (mouse) (phosphorylated) (pSer
12
) (Prod. No.
ALX-210-361
)
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Polyclonal Antibodies
ALX-210-362
Revised 09-Feb-05
Polyclonal Antibody to PPARα (mouse) (phosphorylated) (pSer21)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor α (mouse) (phosphorylated) (pSer
21
) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-362-C100
100 µg
385.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 14-25 (L
14
EADDLEpSPLSE
25
) of mouse PPARα (peroxisome proliferator activated receptor α) phosphorylated at Ser
21
.
SPECIFICITY:
Recognizes mouse PPARα phosphorylated at Ser
21
. Detects a band of ~52kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-056
.
Product Specific Literature References
MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response
:
M.W. Kilgore, et al.; Mol. Cell Endocrinol.
129
, 229 (1997)
Abstract
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
:
R.M. Lavinsky, et al.; PNAS
95
, 2920 (1998)
Abstract
;
Full Text
Related Products
ALX-165-056
Blocking Peptide for PAb to PPARα
(mouse) (phosphorylated) (pSer
21
)
(Prod. No.
ALX-210-362
)
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Polyclonal Antibodies
ALX-210-370
Revised 07-Aug-06
Polyclonal Antibody to ABIN-2
SYNONYMS
anti-A20-Binding Inhibitor of NF-κB 2 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-370-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptides corresponding to human ABIN-2 (A20-binding inhibitor of NF-κB 2).
SPECIFICITY:
Recognizes human and mouse ABIN-2. Detects a band of ~66kDa by Western blot.
APPLICATION:
Western Blot (0.5-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
TLRs Other Products
•
Polyclonal Antibodies
ALX-210-390
Revised 27-Sep-05
Polyclonal Antibody to Histone γ-H2AX (human) (phosphorylated) (pSer139)
SYNONYMS
anti-Histone H2AFX (human) (phosphorylated) (pSer
139
) PAb
anti-Histone H2A.X (human) (phosphorylated) (pSer
139
) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-390-R050
50 µl
150.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.67mg/ml.
FORMULATION:
Liquid. Affinity purified antibody in PBS containing 0.01% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to human histone γ-H2AX (K
134
ATQApSQEY
142
) phosphorylated at Ser
139
.
SPECIFICITY:
Recognizes Ser
139
-phosphorylated human histone γ-H2AX. Does not cross-react with non-phosphorylated human histone γ-H2AX.
APPLICATION:
Immunocytochemistry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
:
E.P. Rogakou, et al.; J. Biol. Chem.
273
, 5858 (1998)
Abstract
;
Full Text
Hyperphosphorylation of histone H2A.X and dephosphorylation of histone H1 subtypes in the course of apoptosis
:
H. Talasz, et al.; Cell Death Differ.
9
, 27 (2002)
Abstract
Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells
:
L. Tartier, et al.; Mutagenesis
18
, 411 (2003)
Abstract
Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin
:
M.D. Meneghini, et al.; Cell
112
, 725 (2003)
Abstract
General Literature References
SET-ting the stage for life and death
:
D. Chakravarti and R. Hong; Cell
112
, 589 (2003)
Abstract
Cancer: protective packaging for DNA
:
J.A. Downs and S.P. Jackson; Nature
424
, 732 (2003)
Abstract
Further Categories Containing This Product:
Phospho-specific Antibodies
•
DNA-based Apoptosis Detection
•
Polyclonal Antibodies
ALX-210-416
Revised 01-Nov-07
Polyclonal Antibody to Deoxyribonuclease I
SYNONYMS
anti-DNase I PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA Endonucleases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-416-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Neat serum.
IMMUNOGEN:
Synthetic peptide corresponding to aa 66-76 (H
66
LVAVGKLLDE
76
) of mouse deoxyribonuclease I (DNase I).
SPECIFICITY:
Recognizes a DNase I specific fragment in human, mouse, rat and bovine. No cross-reactivity against other members of the DNase I family (DNase X, DNaseγ and DNAS1L2).
APPLICATION:
ELISA
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Expression pattern of the Deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse
:
M. Napirei, et al.; Biochem. J.
380
, 929 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
For more information
click here
to download a poster showing the production and use (ELISA, Western blot, Immunohistochemistry) of PAb to Deoxyribonuclease I (Prod. No.
ALX-210-416
).
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-420
Revised 31-Aug-06
Polyclonal Antibody to FOXP3 (mouse)
SYNONYMS
anti-Forkhead Box Protein P3 (mouse) PAb
anti-Scurfin (mouse) PAb
