ALEXIS Biochemicals: Polyclonal Antibody to Viperin (AT131)

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ALX-210-956

Revised 23-Jul-08

Polyclonal Antibody to Viperin (AT131)
SYNONYMS	anti-Virus Inhibitory Protein, Endoplasmic Reticulum-associated, Interferon-inducible PAb (AT131) anti-RSAD2 PAb (AT131) anti-Radical S-adenosyl Methionine Domain-containing Protein 2 PAb (AT131) anti-Cig5 PAb (AT131) anti-Cytomegalovirus-induced Gene 5 Protein PAb (AT131)
PRODUCT LINE	Viral Signalling
PRODUCT CATEGORY	Antiviral Agents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-956-C100		100 µg	350.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY:	Epitope-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa near the C-terminus of human viperin.
SPECIFICITY:	Recognizes human and mouse viperin.
APPLICATION:	Immunoprecipitation (1:200) Western blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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General Information

Viperin has been identified as a human cytomegalovirus and IFN-γ inducible protein. Its expression is activated by both TLR3-dependent and RIG-I-dependent pathways. Viperin inhibits influenza A virus release of infected cells by altering plasma membrane fluidity and the formation of lipid rafts. It acts on the lipid rafts by decreasing the activity of the enzyme farnesyl diphosphate synthase (FPPS) which is essential for isoprenoid biosynthesis.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q8WXG1: Viperin (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus: K.C. Chin & P. Cresswell; PNAS 99, 2460 (2002) Abstract; Full Text
TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5: M.A. Rivieccio, et al.; J. Immunol. 177, 4735 (2006) Abstract; Full Text

Further Categories Containing This Product:

Interferons Other Products • Influenza Viruses / Related Products • Polyclonal Antibodies