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Renin-Angiotensin-Aldosterone System [RAAS] / Related Products
You are here: Product Lines > Signal Transduction > Hormones & Hormone Receptors / Related Products > Renin-Angiotensin-Aldosterone System [RAAS] / Related Products
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ALX-270-212 Revised 26-Jan-07
Captopril
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SYNONYMS (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-212-G001   1 g 20.00 USD Add To Cart
ALX-270-212-G005   5 g 70.00 USD Add To Cart
Product Specification
FORMULA: C9H15NO3S
MW: 217.3
CAS NUMBER: 62571-86-2
MERCK INDEX: 14: 1774
RTECS: UY0550000
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, chloroform, dichloromethane or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE TERATOGENIC. HARMFUL.

Product Description
First orally active angiotensin-converting enzyme (ACE) inhibitor. Reversible and competitive inhibitor of LTA4 hydrolase. Inhibits angiogenesis. Antihypotensive agent.
 
 
ALX-270-213 Revised 13-Dec-06
S-Nitrosocaptopril
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-213-M010   10 mg 60.00 USD Add To Cart
ALX-270-213-M050   50 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C9H14N2O4S
MW: 246.3
PURITY: ≥98%
APPEARANCE: Red crystals.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Angiotensin-converting enzyme (ACE) inhibitor. Inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, yielding nitric oxide (NO) and the parent compound, captopril (Prod. No. ALX-270-212).
Product Specific Literature References
S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets: J. Loscalzo, et al.; J. Pharmacol. Exp. Ther. 249, 726 (1989) Abstract
S-nitrosocaptopril. II. Effects on vascular reactivity: J.P. Cooke, et al.; J. Pharmacol. Exp. Ther. 249, 730 (1989) Abstract
The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs: J.E. Shaffer, et al.; J. Pharmacol. Exp. Ther. 256, 704 (1991) Abstract
Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier: J.W. Park; BBRC 189, 206 (1992) Abstract
Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide: M. Amano, et al.; J. Cardiovasc. Pharmacol. 24, 860 (1994) Abstract
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin: T. Matsumoto, et al.; J. Pharmacol. Exp. Ther. 275, 1247 (1995) Abstract
The effects of S-nitrosocaptopril on canine coronary circulation: I. Nakae, et al.; J. Pharmacol. Exp. Ther. 274, 40 (1995) Abstract
The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats: L. Jia & R.C. Blantz; Eur. J. Pharmacol. 354, 33 (1998) Abstract
Physicochemistry, pharmacokinetics, and pharmacodynamics of S-nitrosocaptopril crystals, a new nitric oxide donor: L. Jia, et al.; J. Pharm. Sci. 88, 981 (1999) Abstract
Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor: L. Jia, et al.; Eur. J. Pharmacol. 391, 137 (2000) Abstract
In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S-nitrosylated captopril, a nitric oxide donor: L. Jia & H. Wong; Br. J. Pharmacol. 134, 1697 (2001) Abstract
S-nitrosocaptopril: in vitro characterization of pulmonary vascular effects in rats: D.Y. Tsui, et al.; Br. J. Pharmacol. 138, 855 (2003) Abstract
S-nitrosocaptopril: acute in-vivo pulmonary vasodepressor effects in pulmonary hypertensive rats: D.Y. Tsui, et al.; J. Pharm. Pharmacol. 55, 1121 (2003) Abstract
 
 
ALX-151-037 Revised 23-Nov-06
Angiotensin I
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-037-M005   5 mg 30.00 USD Add To Cart
ALX-151-037-M025   25 mg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
FORMULA: C62H89N17O14
MW: 1296.5
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-038 Revised 23-Nov-06
Angiotensin I (1-9)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-038-M005   5 mg 75.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
FORMULA: C56H78N16O13
MW: 1183.3
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-039 Revised 22-Jan-07
Angiotensin II
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-039-M005   5 mg 30.00 USD Add To Cart
ALX-151-039-M025   25 mg 125.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
FORMULA: C50H71N13O12
MW: 1046.2
PURITY: ≥98% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-040 Revised 23-Nov-06
Angiotensin I/II (1-5)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-040-M005   5 mg 95.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-OH
FORMULA: C30H48N8O9
MW: 664.7
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-041 Revised 19-Jan-07
Angiotensin I/II (1-7)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-041-M005   5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH
FORMULA: C41H62N12O11
MW: 899.0
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: TFA salt.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-042 Revised 11-Dec-07
Angiotensin IV
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SYNONYMS Angiotensin I/II (3-8)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-042-M005   5 mg 45.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Tyr-Ile-His-Pro-Phe-OH
FORMULA: C40H54N8O8
MW: 774.9
PURITY: ≥99%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-151-043 Revised 07-Feb-08
Angiotensin III
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin & Angiotensin Receptors / Related Products
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ALX-151-043-M005   5 mg 35.00 USD Add To Cart
ALX-151-043-M025   25 mg 140.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
FORMULA: C46H66N12O9
MW: 931.1
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-260-008 Revised 26-Jan-05
Foroxymithine
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SYNONYMS (3S,6S)-3-[3-[N-[N-(Nα-Acetyl-Nδ-formyl-Nδ-hydroxy-L-ornithyl)-L-seryl-N-(hydroxy)amino]propyl]-6-[3-(N-formyl-N-hydroxyamino)propyl]-2,5-piperazinedione
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
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ALX-260-008-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C22H37N7O11
MW: 575.6
CAS NUMBER: 100157-28-6
SOURCE/HOST: Microbial.
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of angiotensin I converting enzyme.
Product Specific Literature References
Influence of angiotensin-converting enzyme inhibitor, foroxymithine, on dynamic equilibrium around the renin-angiotensin system in vivo: T. Aoyagi, et al.; J. Appl. Biochem. 7, 388 (1985) Abstract
Foroxymithine, a new inhibitor of angiotensin-converting enzyme, produced by actinomycetes: H. Umezawa, et al.; J. Antibiot. (Tokyo) 38, 1813 (1985) Abstract
 
 
ALX-201-256 Revised 18-Mar-08
Renin (human) (recombinant)
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SYNONYMS Angiotensinogenase (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Renin-Angiotensin-Aldosterone System [RAAS] Other Products
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ALX-201-256-C010   10 µg 115.00 USD Add To Cart
Product Specification
MW: ~37-45kDa (depending on glycosylation)
EC: 3.4.23.15
SOURCE/HOST: Produced in CHO cells.
CONCENTRATION: 0.2mg/ml
PURITY: ≥85% (SDS-PAGE)
FORMULATION: Liquid. In 150mM sodium acetate, pH 6.0, containing 5mM EDTA.
SPECIFIC ACTIVITY: One unit is defined as the amount of enzyme that releases 1nmol of EDANS per min. at 37°C in 50mM TRIS-HCl, pH 8.0, containing 100mM sodium chloride and 10µM of Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for 6 months after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P00797: Renin (human) (precursor)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-330 Revised 24-Jul-06
ACE2 (human):Fc (human) (recombinant)
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SYNONYMS Angiotensin-converting Enzyme 2 (human):Fc (human) (recombinant)
SARS Receptor (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
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ALX-201-330-C050   50 µg 370.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide sequence and the extracellular domain of human ACE2 (angiotensin-converting enzyme 2) (aa 1-740) are fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test).
BIOLOGICAL ACTIVITY: Converts angiotensin I to angiotensin-(1-9).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9NRA7: Angiotensin converting enzyme-like protein (human)

MANUFACTURER Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion ProteinsSARS Coronavirus / Related Products
 
 
ALX-201-356 Revised 18-Mar-08
ACE2, Soluble (human) (recombinant)
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SYNONYMS Angiotensin-converting Enzyme 2, Soluble (human) (recombinant)
SARS Receptor, Soluble (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Angiotensin Converting Enzyme [ACE] & ACE2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-356-C010   10 µg 295.00 USD Add To Cart
ALX-201-356-C050   50 µg 795.00 USD Add To Cart