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Neurobiology
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ALX-162-001 Revised 22-Oct-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (1 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis. Stimulates phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
ALX-162-002 Revised 09-Oct-08
MCD Peptide
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SYNONYMS Mast Cell Degranulating Peptide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-002-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
(Disulfide bonds between Cys3-Cys15 and Cys5-Cys19)
FORMULA: C110H192N40O24S4
MW: 2587.2
CAS NUMBER: 83856-13-7
SOURCE/HOST: Synthetic. Originally isolated from Apis mellifera.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K+ channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.
Product Specific Literature References
Bee and wasp venoms: E. Haberman; Science 177, 314 (1972) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Further Categories Containing This Product:
Peptides • K+ Channel Blockers & Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-162-009 Revised 04-Jul-07
Myelin Basic Protein (4-14) (bovine)
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SYNONYMS MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-009-M001   1 mg 85.00 USD Add To Cart
ALX-162-009-M005   5 mg 330.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H103N21O17
MW: 1390.6
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific and convenient substrate for protein kinase C (PKC). Very poor substrate for phosphorylase kinase, CaM kinase II, casein kinases I and II and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts: Y.J.K. Farrar, et al.; BBRC 180, 694 (1991) Abstract
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-010 Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)
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SYNONYMS MBP (104-118) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-010-M001   1 mg 95.00 USD Add To Cart
ALX-162-010-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
FORMULA: C70H111N23O19
MW: 1578.8
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein: R.S. Turner, et al.; J. Biol. Chem. 260, 11503 (1985) Abstract; Full Text
Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C): H. Su, et al.; BBRC 134, 78 (1986) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-016 Revised 04-Jul-07
[Pyr4]-Myelin Basic Protein (4-14) (bovine)
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SYNONYMS [Pyr4]-MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-016-M001   1 mg 95.00 USD Add To Cart
ALX-162-016-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H100N20O17
MW: 1373.6
CAS NUMBER: 136132-68-8
PURITY: ≥96%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for protein kinase C (PKC).
Product Specific Literature References
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Peptide fragments of myelin basic protein as substrates of protein kinase C: M. Eller, et al.; Biochem. Int. 27, 625 (1992) Abstract
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-162-019 Revised 04-Jul-07
[Ala96]-Myelin Basic Protein (87-99) (human, bovine, rat)
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SYNONYMS [Ala96]-MBP (87-99) (human, bovine, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-019-M001   1 mg 80.00 USD Add To Cart
ALX-162-019-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Ala-Arg-Thr-Pro-OH
FORMULA: C72H112N20O17
MW: 1529.8
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein: S. Brocke, et al.; Nature 379, 343 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-030 Revised 18-Jan-07
Myelin Oligodendrocyte Glycoprotein (35-55) (mouse, rat)
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SYNONYMS MOG (35-55) (mouse, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-030-MC05   0.5 mg 90.00 USD Add To Cart
ALX-162-030-M001   1 mg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
FORMULA: C118H177N35O29S
MW: 2582.0
PURITY: ≥85% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: <1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism: S. Pluchino, et al.; Nature 436, 266 (2005) Abstract
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy: E. Zappia, et al.; Blood 106, 1755 (2005) Abstract; Full Text
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice: G. van Loo, et al.; Nat. Immunol. 7, 954 (2006) Abstract
General Information
MANUFACTURER Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases: F. Lolli, et al.; Curr. Protein Pept. Sci. 4, 277 (2003) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-031 Revised 14-Aug-06
Myelin Proteolipid Protein (139-151) (human, bovine, dog, mouse, rat)
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SYNONYMS PLP (139-151) (human, bovine, dog, mouse, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-031-M001   1 mg 80.00 USD Add To Cart
Product Specification
SEQUENCE: H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
FORMULA: C72H104N20O16S
MW: 1537.8
PURITY: ≥85% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: <1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism: S. Pluchino, et al.; Nature 436, 266 (2005) Abstract
General Information
MANUFACTURER Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases: F. Lolli, et al.; Curr. Protein Pept. Sci. 4, 277 (2003) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-032 Revised 14-Aug-06
[Ser140]-Myelin Proteolipid Protein (139-151) (human, bovine, dog, mouse, rat)
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SYNONYMS [Ser140]-PLP (139-151) (human, bovine, dog, mouse, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-032-M001   1 mg 80.00 USD Add To Cart
Product Specification
SEQUENCE: H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
FORMULA: C72H104N20O17
MW: 1521.7
PURITY: ≥85% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: <1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice: V.K. Tuohy, et al.; J. Immunol. 142, 1523 (1989) Abstract
General Information
MANUFACTURER Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases: F. Lolli, et al.; Curr Protein Pept Sci 4, 277 (2003) ; Curr. Protein Pept. Sci. 4, 277 (2003) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-162-033 Revised 04-Jul-07
Myelin Basic Protein (87-99) (human, bovine, rat)
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SYNONYMS MBP (87-99) (human, bovine, rat)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-033-M001   1 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-OH
FORMULA: C74H114N20O17
MW: 1555.8
PURITY: ≥85% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: <1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
General Information
MANUFACTURER Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases: F. Lolli, et al.; Curr. Protein Pept. Sci. 4, 277 (2003) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-163-001 Revised 13-Feb-08
Nociceptin
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SYNONYMS Orphanin FQ
PRODUCT LINE Neurobiology
PRODUCT CATEGORY ORL1-Receptors / Related Products
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ALX-163-001-P001   1 mg* 70.00 USD Add To Cart
ALX-163-001-P005   5 mg* 280.00 USD Add To Cart
Product Specification
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SEQUENCE: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
FORMULA: C79H129N27O22