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Natural Products - Antitumor Reagents
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ALX-350-110 Revised 08-Apr-08
Nidulal
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-110-MC05   0.5 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C15H16O5
MW: 276.3
SOURCE/HOST: Isolated from Nidula candida.
PURITY: ≥95%
APPEARANCE: Lyophilized
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep cool and dry. Protect from light.
HAZARD: TOXIC.

Product Description
Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells selectively activates AP-1 dependent signal transduction in a manner similar to TPA/PMA (Prod. No. ALX-445-004).
Product Specific Literature References
Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida: G. Erkel, et al.; J. Antibiot. 49, 1189 (1996) Abstract
Further Categories Containing This Product:
Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-113 Revised 28-May-08
Gossypol
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SYNONYMS 2,2’-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-
methylnaphthalene]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-113-M100   100 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C30H30O8
MW: 518.6
CAS NUMBER: 303-45-7
MERCK INDEX: 14: 4528
RTECS: DU3100000
SOURCE/HOST: Isolated from Gossypium genus, Malvaceae.
PURITY: ≥90%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in acetone or DMSO; sparingly soluble in 100% ethanol (2mg/ml) or methanol (2mg/ml). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor.
Product Specific Literature References
Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules: F.J. Medrano and J.M. Andreu; Eur. J. Biochem. 158, 63 (1986) Abstract
Differential inhibition of protein kinase C subtypes: J.M. Pelosin, et al.; BBRC 169, 1040 (1990) Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994) Abstract
Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle: F. Shidaifat, et al.; Anticancer Res. 17, 1003 (1997) Abstract
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington’s disease therapy: V. Heiser, et al.; PNAS 97, 6739 (2000) Abstract; Full Text
Cytotoxic effect of gossypol on colon carcinoma cells: X. Wang, et al.; Life Sci. 67, 2663 (2000) Abstract
Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol: R. Baumgrass, et al.; J. Biol. Chem. 276, 47914 (2001) Abstract; Full Text
Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani: L.S. Puckhaber, et al.; J. Agric. Food Chem. 50, 7017 (2002) Abstract
Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor: M. Mego; Bratisl. Lek. Listy 103, 378 (2002) Abstract
An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines: M. Le Blanc, et al.; Pharmacol. Res. 46, 551 (2002) Abstract
Gossypol induces chloride secretion in rat proximal colon: G. Kuhn, et al.; Eur. J. Pharmacol. 457, 187 (2002) Abstract
Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism: T.B. Freedman, et al.; Chirality 15, 196 (2003) Abstract
In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells: C.L. Oliver, et al.; Clin. Cancer Res. 10, 7757 (2004) Abstract; Full Text
The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway: J. Jiang, et al.; Anticancer Res. 24, 19 (2004) Abstract
(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer: L. Xu, et al.; Mol. Cancer Ther. 4, 197 (2005) Abstract; Full Text
Investigations on gossypol: past and present developments: K. Dodou; Expert Opin. Investig. Drugs 14, 1419 (2005) Abstract
An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2): E. Konac, et al.; Exp. Oncol. 27, 81 (2005) Abstract; Full Text
Further Categories Containing This Product:
Bcl-2 Family Modulators • PKC Inhibitors • Natural Products - Protein Kinase Inhibitors • PP2B [Calcineurin] / Related Products • Antitumor Agents (Apoptosis Inducers) • Natural Products - Antioxidants • Polyphenols Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-350-118 Revised 22-Sep-08
Deguelin
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SYNONYMS [-]-Deguelin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-118-M005   5 mg 60.00 USD Add To Cart
ALX-350-118-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C23H22O6
MW: 394.4
CAS NUMBER: 522-17-8
MERCK INDEX: 14: 2863
RTECS: DX1500000
PURITY: ≥95%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in acetone, acetonitrile or DMSO. Slightly soluble in 100% ethanol. Insoluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of Akt (protein kinase B; PKB) in an in vitro lung carcinogenesis progression model. Inhibits cell proliferation - cells accumulate in the G2-M phase of the cell cycle. Induces apoptosis. Exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Inhibits cyclooxygenase-2 (COX-2) expression.
Product Specific Literature References
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest: G. Murillo, et al.; Eur. J. Cancer 38, 2446 (2002) Abstract
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells: K.H. Chun, et al.; J. Natl. Cancer Inst. 95, 291 (2003) Abstract; Full Text
Cancer Chemopreventive Activity of Rotenoids from Derris trifoliata: C. Ito, et al.; Planta Med. 70, 8 (2004) Abstract
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.: N. Hail, et al.; Apoptosis 9, 437 (2004) Abstract
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells: H.Y. Lee, et al.; Clin. Cancer Res. 10, 1074 (2004) Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K] / Related Products • Antitumor Agents (Apoptosis Inducers) • Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors) • COX Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-124 Revised 05-Apr-08
Ferulenol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-124-M001   1 mg 45.00 USD Add To Cart
ALX-350-124-M005   5 mg 135.00 USD Add To Cart
ALX-350-124-M010   10 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C24H30O3
MW: 366.5
CAS NUMBER: 6805-34-1
SOURCE/HOST: Isolated from Ferula communis.
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.
Product Specific Literature References
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Natural Products for Cell Cycle Research • Natural Products - Antitumor Reagents
 
 
ALX-350-129 Revised 04-Dec-07
Aristoforin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-129-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C37H54O6
MW: 594.8
CAS NUMBER: 849215-53-8
PURITY: ≥95%
APPEARANCE: White to yellow oil.
SOLUBILITY: Soluble in DMSO or 100mM sodium hydrogen carbonate/2% DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Stable and water-soluble derivative of hyperforin (Prod. No. ALX-350-097) inducing apoptosis. Antitumor agent. Inhibits sirtuins.
Product Specific Literature References
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem. 6, 171 (2005) Abstract
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2: C. Gey, et al.; Angew. Chem. Int. Ed. Engl. 46, 5219 (2007) Abstract
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Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Sirtuins / Related Products • Natural Products - Antitumor Reagents
 
 
ALX-350-133 Revised 28-May-08
Topotecan . hydrochloride
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SYNONYMS 9-[(Dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin . HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Topoisomerase Inhibitors
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ALX-350-133-M001   1 mg 30.00 USD Add To Cart
ALX-350-133-M005   5 mg 90.00 USD Add To Cart
ALX-350-133-M025   25 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C23H23N3O5 . HCl
MW: 421.5 . 36.5
CAS NUMBER: 119413-54-6
MERCK INDEX: 14: 9548
SOURCE/HOST: Semisynthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Light yellow to greenish powder.
SOLUBILITY: Soluble in water (1mg/ml) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin (Prod. No. ALX-350-015). Used in chemotherapy of several different cancers.
Product Specific Literature References
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity: W.D. Kingsbury, et al.; J. Med. Chem. 34, 98 (1991) Abstract
In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells: F.M. Uckun, et al.; Blood 85, 2817 (1995) Abstract
Clinical status and optimal use of topotecan: C.H. Takimoto & S.G. Arbuck; Oncology (Williston Park) 11, 1635 (1997), Review Abstract
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues: B. Arun & E.P. Frenkel; Expert Opin. Pharmacother. 2, 491 (2001), Review Abstract
Topotecan for the treatment of small-cell lung cancer: S.J. Nicum & M.E. O´Brien; Expert Rev. Anticancer Ther. 7, 795 (2007) Abstract
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Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-350-137 Revised 05-Apr-08
Fasciculatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-137-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C25H34O4
MW: 398.5
CAS NUMBER: 37905-12-7
SOURCE/HOST: Isolated from Ircinia fasciculata.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL. CYTOTOXIC.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Secondary metabolite of marine sponges. Shows moderate cytotoxicity.
Product Specific Literature References
Fasciculatin, a novel sesterterpene from the sponge Ircinia fasciculate: L. Minale, et al.; Tetrahedron 28, 1579 (1975)
Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin: N.K. Narain, et al.; J. Chem. Soc. [Perkin. 1] 9, I018 (1977) Abstract
Cytotoxicity and inhibition of lymphocyte proliferation of fasciculatin, a linear furanosesterterpene isolated from Ircinia variabilis collected from the atlantic coast of Morocco: S. Rifai, et al.; Mar. Drugs 3, 15 (2005) Full Text
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
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SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antifungal Agents
 
 
ALX-350-150 Revised 16-Jun-08
Gelonin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-150-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~30kDa
CAS NUMBER: 75037-46-6
SOURCE/HOST: Isolated from Gelonium multiflorum.
CONCENTRATION: 2.1mg/ml
PURITY: ≥95%
FORMULATION: Liquid. In 5mM phosphate buffer, pH 6.5, containing 5mM EDTA and 120mM sodium chloride.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HAZARD: HARMFUL.
Product Description
Type I ribosome inactivating protein (RIP). Depurinates RNA in ribosomes, thus inhibiting protein synthesis in eukaryotic cells, which results in cell death. Widely used to construct immunotoxins composed of cell-targeted antibodies. As a type I RIP it lacks the lectin subunit and is practically non-toxic to intact cells. Inhibits cell-free protein synthesis in reticulocyte assay with globin messenger (IC50=2.7ng/ml).
Product Specific Literature References
Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and prepar