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ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Lipoxygenases / Related Products
•
NF-kB Pathway Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-277
Revised 03-Apr-08
Betulinic acid (high purity)
SYNONYMS
3β-Hydroxy-20(29)-lupaene-28-oic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-277-M005
5 mg
32.00 USD
ALX-350-277-M025
25 mg
95.00 USD
ALX-350-277-M100
100 mg
290.00 USD
Product Specification
FORMULA:
C
30
H
48
O
3
MW:
456.7
CAS NUMBER:
472-15-1
SOURCE/HOST:
Isolated from
Platanus acerifolia
(plane) tree bark.
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
IRRITANT.
Product Description
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator.
Product Specific Literature References
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids:
T. Fujioka, et al.; J. Nat. Prod.
57
, 243 (1994)
Abstract
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis:
E. Pisha, et al.; Nat. Med.
1
, 1046 (1995)
Abstract
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents:
Y. Kashiwada, et al.; J. Med. Chem.
39
, 1016 (1996)
Abstract
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors:
S. Fulda, et al.; Cancer Res.
57
, 4956 (1997)
Abstract
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives:
F. Hashimoto, et al.; Bioorg. Med. Chem.
5
, 2133 (1997)
Abstract
Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma:
M. Rieber & M. Strasberg Rieber; DNA Cell Biol.
17
, 399 (1998)
Abstract
Betulinic acid induces apoptosis in human neuroblastoma cell lines:
M.L. Schmidt, et al.; Eur. J. Cancer
33
, 2007 (1997)
Abstract
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid:
S. Fulda, et al.; J. Biol. Chem.
273
, 33942 (1998)
Abstract
;
Full Text
Betulinic acid inhibits aminopeptidase N activity:
M.F. Melzig & H. Bormann; Planta Med.
64
, 655 (1998)
Abstract
Correspondence re: S. Fulda et al., Betulinic acid triggers CD95 (Apo1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 57: 4956, 1997:
M. Rieber & M. Strasberg Rieber; Cancer. Res.
58
, 5876 (1998)
Abstract
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells:
S. Fulda, et al.; Int. J. Cancer
82
, 435 (1999)
Abstract
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing:
W. Wick, et al.; J Pharmacol. Exp. Ther.
289
, 1306 (1999)
Abstract
;
Full Text
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells:
E. Selzer, et al.; J. Invest. Dermatol.
114
, 935 (2000)
Abstract
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9:
Y. Takada & B.B. Aggarwal; J. Immunol.
171
, 3278 (2003)
Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid:
D. Poeckel, et al.; Br. J. Pharmacol.
146
, 514 (2005)
Abstract
Betulinic acid and its derivatives: a review on their biological properties:
P. Yogeeswari and D. Sriram; Curr. Med. Chem.
12
, 657 (2005), Review
Abstract
Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica:
S. Wada & R. Tanaka; Chem. Biodivers.
2
, 689 (2005)
Abstract
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy:
H. Kasperczyk, et al.; Oncogene
24
, 6945 (2005)
Abstract
Activation and inhibition of the proteasome by betulinic acid and its derivatives:
L. Huang, et al.; FEBS Lett.
581
, 4955 (2007)
Abstract
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription
•
Natural Products - NF-kB Pathway Inhibitors
•
MPTP [Mitochondrial Transition Pore] / Related Products
•
Natural Products - Anti-inflammatory Agents
•
NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
•
HIV / AIDS / Related Products
ALX-350-298
Revised 03-Apr-08
Betulinic acid (~95%)
SYNONYMS
3β-Hydroxy-20(29)-lupaene-28-oic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-298-M100
100 mg
55.00 USD
ALX-350-298-M500
500 mg
180.00 USD
ALX-350-298-G001
1 g
290.00 USD
Product Specification
FORMULA:
C
30
H
48
O
3
MW:
456.7
CAS NUMBER:
472-15-1
SOURCE/HOST:
Isolated from
Platanus acerifolia
(plane tree) bark.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator.
Product Specific Literature References
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids:
T. Fujioka, et al.; J. Nat. Prod.
57
, 243 (1994)
Abstract
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis:
E. Pisha, et al.; Nat. Med.
1
, 1046 (1995)
Abstract
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents:
Y. Kashiwada, et al.; J. Med. Chem.
39
, 1016 (1996)
Abstract
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors:
S. Fulda, et al.; Cancer Res.
57
, 4956 (1997)
Abstract
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives:
F. Hashimoto, et al.; Bioorg. Med. Chem.
5
, 2133 (1997)
Abstract
Betulinic acid induces apoptosis in human neuroblastoma cell lines:
M.L. Schmidt, et al.; Eur. J. Cancer
33
, 2007 (1997)
Abstract
Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma:
M. Rieber & M. Strasberg Rieber; DNA Cell Biol.
17
, 399 (1998)
Abstract
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid:
S. Fulda, et al.; J. Biol. Chem.
273
, 33942 (1998)
Abstract
;
Full Text
Betulinic acid inhibits aminopeptidase N activity:
M.F. Melzig & H. Bormann; Planta Med.
64
, 655 (1998)
Abstract
Correspondence re: S. Fulda et al., Betulinic acid triggers CD95 (Apo1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 57: 4956, 1997:
M. Rieber & M. Strasberg Rieber; Cancer. Res.
58
, 5876 (1998)
Abstract
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells:
S. Fulda, et al.; Int. J. Cancer
82
, 435 (1999)
Abstract
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing:
W. Wick, et al.; J Pharmacol. Exp. Ther.
289
, 1306 (1999)
Abstract
;
Full Text
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells:
E. Selzer, et al.; J. Invest. Dermatol.
114
, 935 (2000)
Abstract
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9:
Y. Takada & B.B. Aggarwal; J. Immunol.
171
, 3278 (2003)
Abstract
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection:
R.H. Cichewicz & S.A. Kouzi; Med. Res. Rev.
24
, 90 (2004), Review
Abstract
Betulinic acid-induced apoptosis in leukemia cells:
H. Ehrhardt, et al.; Leukemia
18
, 1406 (2004)
Abstract
Betulinic acid and its derivatives: a review on their biological properties:
P. Yogeeswari & D. Sriram; Curr. Med. Chem.
12
, 657 (2005), Review
Abstract
Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells:
W. Rzeski, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
374
, 11 (2006)
Abstract
Activation and inhibition of the proteasome by betulinic acid and its derivatives:
L. Huang, et al.; FEBS Lett.
581
, 4955 (2007)
Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
NF-kB Pathway Inhibitors
•
Other Natural Products - DNA Regulation / Transcription
•
Natural Products - NF-kB Pathway Inhibitors
•
MPTP [Mitochondrial Transition Pore] / Related Products
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Antiviral / anti-HIV Agents
•
Antitumor Agents (Apoptosis Inducers)
•
Ubiquitin & Proteasome Other Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
HIV / AIDS / Related Products
ALX-270-480
Revised 10-Mar-08
Caffeic acid ethyl ester
SYNONYMS
CAEE
Ethyl caffeate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-480-M050
50 mg
20.00 USD
ALX-270-480-M250
250 mg
60.00 USD
Product Specification
FORMULA:
C
11
H
12
O
4
MW:
208.2
CAS NUMBER:
66648-50-8
SOURCE/HOST:
Synthetic.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt when stored at -20°C.
HANDLING:
Protect from light and moisture.
Product Description
Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC
50
=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E
2
(PGE
2
) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H
2
O
2
.
Product Specific Literature References
Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells:
T. Nakayama, et al.; Biosci. Biotechnol. Biochem.
60
, 316 (1996)
Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin:
Y.M. Chiang, et al.; Br. J. Pharmacol.
146
, 352 (2005)
Abstract
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines:
M. Cardenas, et al.; Bioorg. Med. Chem.
14
, 2966 (2006)
Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR:
K. Suzuki, et al.; Biofactors
28
, 151 (2006)
Abstract
Related Products
ALX-270-231
Caffeic acid
ALX-270-244
Caffeic acid phenylethyl ester
Further Categories Containing This Product:
Prostaglandins Other Products
•
Natural Products - Chemopreventive Agents
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Nitric Oxide Pathway Modulators
•
Phenolic Acids
•
NF-kB Pathway Inhibitors
ALX-350-278
Revised 08-Apr-08
Caffeic acid n-octyl ester
SYNONYMS
n-Octylcaffeate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-278-M005
5 mg
25.00 USD
ALX-350-278-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
17
H
24
O
4
MW:
292.2
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
More potent analog than CAPE (Prod. No.
ALX-270-244
). Suppressor of inducible nitric oxide synthase (iNOS; NOS II). Induces apoptosis.
Product Specific Literature References
Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids:
B. Etzenhouser, et al.; Bioorg. Med. Chem.
9
, 199 (2001)
Abstract
A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
:
G. Hsiao, et al.; Biochem. Pharmacol.
65
, 1383 (2003)
Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties:
F.M. da Cunha, et al.; Free Radic. Res.
38
, 1241 (2004)
Abstract
Octylcaffeate induced apoptosis in human leukemia U937 cells:
M. Ujibe, et al.; Biol. Pharm. Bull.
28
, 2338 (2005)
Abstract
General Information
Octylcaffeate significantly ameliorates circulatory failure of endotoxemia by suppression of iNOS (NOS II) expression through inactivation of mitogen-activated protein kinases.
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
NF-kB Pathway Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Antioxidants
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Phenolic Acids
ALX-270-244
Revised 03-Apr-08
Caffeic acid phenylethyl ester
SYNONYMS
CAPE
Phenethyl caffeiate
Caffeic acid phenethyl ester
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-244-M010
10 mg
20.00 USD
ALX-270-244-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
17
H
16
O
4
MW:
284.3
CAS NUMBER:
115610-29-2
SOURCE/HOST:
Synthetic.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt when stored at –20°C.
HANDLING:
Protect from light and moisture.
HAZARD:
IRRITANT.
Product Description
Active component of propolis from honeybee hives, known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Potent and specific inhibitor of NF-κB activation, induced by TNF-α
(Prod. No.
ALX-522-008
(human) or Prod. No.
ALX-522-009
(mouse)), PMA (Prod. No.
ALX-445-004
) and other inflammatory agents. Exhibits inhibitory activity against HIV-1 integrase (IC
50
=7µM). Suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Induces apoptosis.
Product Specific Literature References
Hydroxylated aromatic inhibitors of HIV-1 integrase:
T.R. Burke Jr., et al.; J. Med. Chem.
38
, 4171 (1995)
Abstract
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells:
C. Chiao, et al.; Cancer Res.
55
, 3576 (1995)
Abstract
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B:
K. Natarajan, et al.; PNAS
93
, 9090 (1996)
Abstract
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation:
P. Michaluart, et al.; Cancer Res.
59
, 2347 (1999)
Abstract
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation:
Z. Orban, et al.; Neuroimmunomodulation
7
, 99 (2000)
Abstract
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors:
N. Marquez, et al.; J. Pharmacol. Exp. Ther.
308
, 993 (2004)
Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties:
F.M. da Cunha, et al.; Free Radic. Res.
38
, 1241 (2004)
Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR:
K. Suzuki, et al.; Biofactors
28
, 151 (2006)
Abstract
Related Products
ALX-270-231
Caffeic acid
ALX-270-480
Caffeic acid ethyl ester
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents
•
Natural Products - NF-kB Pathway Inhibitors
•
Tyrosine Kinase Inhibitors
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Immunomodulators
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Phenolic Acids
•
NF-kB Pathway Inhibitors
•
HIV / AIDS / Related Products
ALX-270-254
Revised 22-Sep-08
Carnosol
SYNONYMS
1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2
H
-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antioxidants
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-254-M001
1 mg
60.00 USD
ALX-270-254-M005
5 mg
269.00 USD
Product Specification
FORMULA:
C
20
H
26
O
4
MW:
330.4
CAS NUMBER:
5957-80-2
SOURCE/HOST:
Isolated from
Rosmarinus officinalis.
PURITY:
≥96%
APPEARANCE:
White to beige solid.
SOLUBILITY:
Soluble in 100% ethanol (8mg/ml), DMSO (250mg/ml) or dimethyl formamide (35mg/ml); sparingly soluble in aqueous PBS, pH 7.2 (<30μg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).
Product Specific Literature References
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid:
O.I. Aruoma, et al.; Xenobiotica
22
, 257 (1992)
Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production:
M.M. Chan, et al.; Cancer Lett.
96
, 23 (1995)
Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis:
H. Haraguchi, et al.; Planta Med.
61
, 333 (1995)
Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation:
K. Singletary, et al.; Cancer Lett.
104
, 43 (1996)
Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention:
K. Macé, et al.; Arch. Toxicol. Suppl.
20
, 227 (1998)
Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages:
A.H. Lo, et al.; Carcinogenesis
23
, 983 (2002)
Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma:
O. Rau, et al.; Planta Med.
72
, 881 (2006)
Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis:
K. Horiuchi, et al.; Biol. Pharm. Bull.
30
, 287 (2007)
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Natural Products - Chemopreventive Agents
•
Natural Products - NF-kB Pathway Inhibitors
•
Lipid Peroxidation
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Active Substances from Fruit and Vegetables
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Natural Products - Anti-inflammatory Agents
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Natural Products - Nitric Oxide Pathway Modulators
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COX Inhibitors
ALX-350-028
Revised 12-Sep-08
Curcumin (high purity)
SYNONYMS
1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-028-M010
10 mg
15.00 USD
ALX-350-028-M050
50 mg
60.00 USD
ALX-350-028-M250
250 mg
240.00 USD
Product Specification
FORMULA:
C
21
H
20
O
6
MW:
368.4
CAS NUMBER:
458-37-7
MERCK INDEX:
14:
2673
SOURCE/HOST:
Isolated from turmeric (
Curcuma longa
).
PURITY:
≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)
APPEARANCE:
Orange-yellow crystalline powder.
SOLUBILITY:
Soluble in acetic acid or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.
Product Specific Literature References
Modification of certain inflammation-induced biochemical changes by curcumin:
R. Srivastava & R.C. Srimal; Indian J. Med. Res.
81
, 215 (1985)
Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones:
D.L. Flynn, et al.; Prostagl. Leukotr. Med.
22
, 357 (1986)
Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells:
L. Korutla & R. Kumar; Biochim. Biophys. Acta
1224
, 597 (1994)
Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages:
I. Brouet & H. Okshima; BBRC
206
, 533 (1995)
Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin:
J.N. Commandeur & N.P. Vermeulen; Xenobiotica
26
, 667 (1996)
Abstract
Nitric oxide scavenging by curcuminoids:
Sreejayan & M.N. Rao; J. Pharm. Pharmacol.
49
, 105 (1997)
Abstract
Inhibitory effects of curcumin on tumorigenesis in mice:
M.T. Huang, et al.; J. Cell. Biochem. (Suppl.)
27
, 26 (1997)
Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties:
M.M. Chan, et al.; Biochem. Pharmacol.
55
, 1955 (1998)
Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland:
M. Onoda & H. Inano; Nitric Oxide
4
, 505 (2000)
Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide:
B.D. Johnston & E.G. DeMaster; Nitric Oxide
8
, 231 (2003)
Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action:
B. Joe, et al.; Crit. Rev. Food Sci. Nutr.
44
, 97 (2004), (Review)
Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects:
M.E. Egan, et al.; Science
304
, 600 (2004)
Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of
