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Natural Products - Antiviral / anti-HIV Agents
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ALX-350-302 Revised 14-Dec-07
Imperatorin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-302-M002   2 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C16H14O4
MW: 270.3
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in methanol or water. Almonst insoluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
The furanocoumarins heraclenin (Prod. No. ALX-350-303) and imperatorin (Prod. No. ALX-350-302) inhibit T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Both compounds also induce apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways. Imperatorin inhibits HIV-1 replication as well as the expression of ICAM-1 in U937 foam cells. Inhibits voltage-dependent calcium channel.
Product Specific Literature References
Expression of intercellular adhesion molecule-1 in U937 foam cells and inhibitory effect of imperatorin: P.Y. Yang, et al.; Acta Pharmacol. Sin. 23, 327 (2002) Abstract
Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells: H.O. Pae, et al.; Pharmacol. Toxicol. 91, 40 (2002) Abstract
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin: G. Appendino, et al.; J. Nat. Prod. 67, 532 (2004) Abstract
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT: N. Marquez, et al.; Planta Med. 70, 1016 (2004) Abstract
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway: R. Sancho, et al.; J. Biol. Chem. 279, 37349 (2004) Abstract; Full Text
Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release: J.Y. He, et al.; Eur. J. Pharmacol. 573, 170 (2007) Abstract
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Further Categories Containing This Product:
DNA Fragmentation & Chromatin Condensation • Natural Products - Antiviral / anti-HIV Agents • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Ca2+ Channels Other Products • HIV / AIDS / Related Products
 
 
ALX-385-024 Revised 06-Oct-08
Isorhamnetin
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SYNONYMS 3-Methylquercetin
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-024-M005   5 mg 90.00 USD Add To Cart
ALX-385-024-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O7
MW: 316.3
CAS NUMBER: 480-19-3
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone, methanol, ethylacetate or DMSO. Only sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antiviral agent. Antioxidant. Antitumor compound. Apoptosis inducer.
Product Specific Literature References
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima: H. Ito, et al.; Cancer Lett. 143, 5 (1999) Abstract
Inhibition of xanthine oxidase by flavonoids: A. Nagao, et al.; Biosci. Biotechnol. Biochem. 63, 1787 (1999) Abstract
Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products: L. Zou, et al.; Phytomedicine 9, 263 (2002) Abstract
Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes: T. Yokozawa, et al.; J. Agric. Food Chem. 50, 5490 (2002) Abstract
Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils: G. Chen, et al.; Clin. Chim. Acta 326, 169 (2002) Abstract
Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK: M. Bao & Y. Lou; Eur. J. Pharmacol. 547, 22 (2006) Abstract
The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells: G. Ma, et al.; Chem. Biol. Interact. 167, 153 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-350-225 Revised 29-Sep-08
Limonin
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SYNONYMS Limonoic acid di-δ-lactone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-225-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C26H30O8
MW: 470.5
CAS NUMBER: 1180-71-8
MERCK INDEX: 14: 5494
SOURCE/HOST: Isolated from grapefruit seed.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or glacial acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Bitter principle of citrus fruits. Inhibits chemically induced carcinogenesis. Inhibits HIV-1 replication. Shows antinociceptive effect. Does not possess any inherent antioxidant activity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982)
R.L. Rouseff; J. Agric. Food Chem. 30, 504 (1982)
M.A. Altieri, et al.; Protect. Ecol. 6, 91 (1984)
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
L.K.T. Lam, et al.; ACS Symposium Series 546, 209 (1994)
Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri: H. Matsuda, et al.; Planta Med. 64, 339 (1998) Abstract
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats: T. Tanaka, et al.; Biofactors 13, 213 (2000) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Analgesic / Anti-nociceptive Agents / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-350-294 Revised 16-Jun-08
Manzamine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-294-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C36H44N4O
MW: 548.8
CAS NUMBER: 104196-68-1
SOURCE/HOST: Isolated from Xestospongia sp.
PURITY: >98% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).
Product Specific Literature References
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996) Abstract
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000) Abstract; Full Text
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001) Abstract
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003) Abstract
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003) Abstract
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004) Abstract
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett. 8, 2591 (2006) Abstract
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antimalarial Agents • Malaria / Related Products • Natural Products with Antibiotic Activity • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antifungal Agents • GSK-3 Inhibitors • Pesticides / Related Products • Alkaloids
 
 
ALX-350-274 Revised 16-Jun-08
Myriocin
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SYNONYMS ISP-1
Thermozymocidin
2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
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ALX-350-274-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H39NO6
MW: 401.5
CAS NUMBER: 35891-70-4
RTECS: JX3890000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. ALX-380-002). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM). Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM).
Product Specific Literature References
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite: T. Fujita, et al.; J. Antibiot. 47, 208 (1994) Abstract
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin: Y. Miyake, et al.; BBRC 211, 396 (1995) Abstract
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998) Abstract
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells: K. Hidari, et al.; J. Biol. Chem. 271, 14636 (1996) Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000) Abstract; Full Text
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005) Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006) Abstract
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Further Categories Containing This Product:
Sphingolipids & Glycosphingolipids Other Products • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-228 Revised 08-Jul-08
Nomilin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-228-M025   25 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C28H34O9
MW: 514.6
CAS NUMBER: 1063-77-0
MERCK INDEX: 14: 6674
SOURCE/HOST: Isolated from grapefruit seed and citrus juice.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone; slightly soluble in 100% ethanol, methanol, isopropanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Induces phase II detoxifying enzymes and inhibits chemically induced carcinogenesis. Exhibits immunomodulatory activity and also inhibits HIV-1 replication. Does not possess any inherent antioxidant capacity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
Inhibition of benzo[a]pyrene-induced forestomach neoplasia in mice by citrus limonoids: L.K.T. Lam & S. Hasegawa; Nutr. Cancer 12, 43 (1989) Abstract
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system: T.J. Raphael & G. Kuttan; Phytomedicine 10, 483 (2003) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Immunomodulators • Natural Products - Antiviral / anti-HIV Agents • Active Substances from Fruit and Vegetables
 
 
ALX-350-276 Revised 16-Jun-08
Pseudohypericin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-276-M001   1 mg 115.00 USD Add To Cart
ALX-350-276-M005   5 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C30H16O9
MW: 520.5
CAS NUMBER: 55954-61-5
SOURCE/HOST: Isolated from Hypericum perforatum.
PURITY: ≥98%
APPEARANCE: Black to black-red powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, DMSO, acetone and other organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of protein kinase C (PKC) (IC50=15µg/ml). Antiviral and antiretroviral activity. Potent inhibitor of dopamine-β-hydrolase (IC50=3µg/ml).
Product Specific Literature References
Zur Isolierung und Konstitution des Pseudohypericins : H. Brockmann, et al.; Tetrahedron Lett. 15, 1991 (1974)
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin: D. Meruelo, et al.; PNAS 85, 5230 (1988) Abstract
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin: G. Lavie, et al.; PNAS 86, 5963 (1989) Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity: I. Takahashi, et al.; BBRC 165, 1207 (1989) Abstract
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids: A. Denke, et al.; Arzneimittelforschung 50, 415 (2000) Abstract
Antagonist effect of pseudohypericin at CRF1 receptors: U. Simmen, et al.; Eur. J. Pharmacol. 458, 251 (2003) Abstract
Phototoxic and apoptosis-inducing capacity of pseudohypericin: C.M. Schempp, et al.; Planta Med. 68, 171 (2002) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Natural Products - Antiviral / anti-HIV Agents • Natural Products for Neurological Research • Neuroactive Agents Other Products
 
 
ALX-350-364 Revised 08-Apr-08
Psoralen
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SYNONYMS Ficusin
7H-Furo[3,2-g]benzopyran-7-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-364-M025   25 mg 95.00 USD Add To Cart
ALX-350-364-M100   100 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C11H6O3
MW: 186.2
CAS NUMBER: 66-97-7
MERCK INDEX: 14: 7928
RTECS: LV0944000
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in ethyl acetate or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.
Product Specific Literature References
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science 217, 733 (1982) Abstract
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem. 54, 1151 (1985), (Review) Abstract
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol. 193, 377 (1987) Abstract
Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol. 212, 242 (1992) Abstract
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res. 58, 1400 (1998) Abstract; Full Text
Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol. 83, 449 (2005) Abstract
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res. 35, 5672 (2007) Abstract; Full Text
Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res. 35, 7604 (2007) Abstract; Full Text
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antifungal Agents • DNA Intercalators & Crosslinkers • Pesticides / Related Products
 
 
ALX-350-296 Revised 30-Jun-08
Thalassiolin B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral / anti-HIV Agents
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ALX-350-296-MC05   0.5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C22H22O14S
MW: 542.5
SOURCE/HOST: Isolated from Thalassia testudinum.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to green oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of HIV cDNA integrase.
Product Specific Literature References
Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase: D.C. Rowley, et al.; Bioorg. Med. Chem. 10, 3619 (2002) Abstract