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ALX-210-131
Revised 19-Nov-07
Polyclonal Antibody to Glucocorticoid Receptor
SYNONYMS
anti-GR PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Glucocorticoids & Glucocorticoid Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-131-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 346-367 (D
346
QKPIFNVIPPIPVGSENWNRC
367
) of human GR (glucocorticoid receptor).
SPECIFICITY:
Recognizes all forms of human, mouse and rat GR. Detects a band of ~97kDa by Western blot. Does not interfere with receptor DNA binding.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry (paraffin sections)
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-157-015
.
Product Specific Literature References
Novel antipeptide antibodies to the human glucocorticoid receptor: recognition of multiple receptor forms in vitro and distinct localization of cytoplasmic and nuclear receptors:
J.A. Cidlowski, et al.; Mol. Endocrinol.
4
, 1427 (1990)
Abstract
Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells:
J.E. Pawlowski, et al.; J. Biol. Chem.
277
, 20702 (2002)
Abstract
;
Full Text
Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells:
E.R. James, et al.; Invest. Ophthalmol. Vis. Sci.
44
, 5269 (2003)
Abstract
;
Full Text
Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A:
D.L. Drazen, et al.; Endocrinology
145
, 3404 (2004)
Abstract
Related Products
ALX-157-015
Blocking Peptide for PAb to Glucocorticoid Receptor (Prod. No.
ALX-210-131
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-132
Revised 07-Jan-08
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-132-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 512-530 (C
512
SSTEDSKN KESSQNLQSQ
530
) of C-terminal rat ERβ (estrogen receptor β
).
SPECIFICITY:
Recognizes human, mouse and rat ERβ.
Detects a band of ~55kDa by Western blot. Does not
cross-react with ERα.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry ((paraffin sections, frozen sections (1:50))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-025
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice:
C.S. Rosenfeld, et al.; Endocrinology
139
, 2982 (1998)
Abstract
Generation and reproductive phenotypes of mice lacking estrogen receptor beta:
J.H. Krege, et al.; PNAS
95
, 15677 (1998)
Abstract
;
Full Text
Distribution of estrogen-beta-like immunoreactivity in rat forebrain:
X. Li, et al.; Neuroendocrinology
66
, 63 (1997)
Abstract
Related Products
ALX-155-025
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-132
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-134
Revised 12-Mar-08
Polyclonal Antibody to Furin Convertase
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Convertases / Related Products / Furin
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-134-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Dog
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 780-793 (R
780
GERTAFIKDQSAL
793
) of C-terminal mouse furin convertase.
SPECIFICITY:
Recognizes mouse and dog furin convertase and overexpressed human furin convertase. Detects a band of ~100kDa by Western blot. Does not detect endogenous furin from BSC-40, HeLa, J774A-1 BPAEC or CHO cells. Does not cross-react with rat furin convertase.
APPLICATION:
Immunocytochemistry
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-001
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway:
G. Liu, et al.; J. Cell Biol.
139
, 1719 (1997)
Abstract
;
Full Text
Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation
:
X. Wang & D. Pei; J. Biol. Chem.
276
, 35953 (2001)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Immunocytochemical staining of endogenous furin convertase in 3T3 cells with Prod. No.
ALX-210-134
yields a pattern consistent with paranuclear staining.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-135
Revised 21-May-08
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-135-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 100-115 (A
100
EPQKSPWCEARSLEH
115
) of human, mouse and rat ERβ (estrogen receptor β).
SPECIFICITY:
Recognizes human, mouse, rat, sheep and monkey ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION:
Gel Shift Assay (1-5µg/ml)
Immunocytochemistry (2-4µg/ml))
Immunohistochemistry ((frozen sections, paraffin sections (1-2µg/ml))
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-027
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Cloning of a novel receptor expressed in rat prostate and ovary:
G.G.J.H. Kuiper, et al.; PNAS
93
, 5925 (1996)
Abstract
ER beta: identification and characterization of a novel human estrogen receptor:
S. Mosselman, et al.; FEBS Lett.
392
, 49 (1996)
Abstract
Transcription and translation of estrogen receptor b in the male reproductive tract of estrogen receptor a-knock-out and wild-type mice:
C.S. Rosenfeld, et al.; Endocrinology
139
, 2982 (1998)
Abstract
Differing roles found for estrogen's two receptors:
E. Pennisi; Science
277
, 1439 (1997), (Research News)
Abstract
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta:
G.B. Tremblay, et al.; Mol. Endocrinol.
11
, 353 (1997)
Abstract
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta:
G.G.J.H. Kuiper, et al.; Endocrinology
138
, 863 (1997)
Abstract
Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain:
X. Li, et al.; Neuroendocrinology
66
, 63 (1997)
Abstract
A new actor in the estrogen receptor drama--enter ER-beta:
B.S. Katzenellenbogen & K.S. Korach; Endocrinology
138
, 861 (1997), (Editorial)
Abstract
Related Products
ALX-155-027
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-135
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-137/1
Revised 21-Aug-07
Polyclonal Antibody to BiP
SYNONYMS
anti-GRP78 PAb
anti-Glucose Regulated Protein 78 PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP70 / DnaK / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-137/1-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 643-654 (T
643
GEEDTSEKDEL
654
) of rat BiP (GRP78; glucose regulated protein 78kDa).
SPECIFICITY:
Recognizes mouse and rat BiP. Does not detect BiP from human cell lines or COS cells.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Polyclonal Antibodies
•
Autophagy Other Products
ALX-210-138
Revised 19-Jan-05
Polyclonal Antibody to HSP84
SYNONYMS
anti-Heat Shock Protein 84 PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP90 / HtpG / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-138-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope affinity purified IgG containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-13 (P
2
EEVHHGEEEVE
13
) of mouse HSP84 (heat shock protein 84).
SPECIFICITY:
Recognizes human, mouse and rat HSP84. Does not cross-react with HSP86.
APPLICATION:
Immunocytochemistry (15µg/ml)
Immunoprecipitation
Western Blot (0.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells:
G.H. Perdew; Exp. Cell. Res.
209
, 350 (1993)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-139
Revised 28-Sep-05
Polyclonal Antibody to HSP86
SYNONYMS
anti-Heat Shock Protein 86 PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP90 / HtpG / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-139-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-12 (P
2
EETQTQDQPM
12
) of mouse HSP86 (heat shock protein 86).
SPECIFICITY:
Recognizes human, mouse, rat and sheep HSP86. Does not cross-react with HSP84. Detects a bend of ~86kDa by Western blot.
APPLICATION:
Immunocytochemistry (10-15µg/ml)
Immunohistochemistry (paraffin sections (5µg/ml))
Immunoprecipitation
Western Blot (0.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells:
G.H. Perdew; Exp. Cell. Res.
209
, 350 (1993)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-140
Revised 30-Oct-06
Polyclonal Antibody to HSP104
SYNONYMS
anti-Heat Shock Protein 104 PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Heat Shock Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-140-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 894-908 (D
894
DDNEDSMEIDDDLD
908
) of C-terminal
S. cerevisiae
HSP104 (heat shock protein 104).
SPECIFICITY:
Recognizes human, mouse, hamster and yeast HSP104. Detects a band of ~104kDa (yeast) or 100-105kDa (mammalian) by Western blot. Does not cross-react with HSP100 from prokaryotes, nor certain plants or insects including
Drosophila
.
APPLICATION:
Immunocytochemistry (1:500 for yeast HSP104)
Immunoprecipitation
Western Blot (1:5'000 for yeast HSP104; 1:100 for mammalian proteins)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Hsp104 is a highly conserved protein with two essential nucleotide- binding sites:
D.A. Parsell, et al.; Nature
353
, 270 (1991)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-141
Revised 10-Jan-05
Polyclonal Antibody to KDEL/GRP78
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Stress & Heat Shock Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-141-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized. Purified IgG containing
0.05% sodium azide.
RECONSTITUTION:
Reconstitute in PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 643-654 (CT
643
GEEDTSEKDEL
654
) of rat GRP78 (glucose regulated protein 78).
SPECIFICITY:
Recognizes mouse, rat and hamster endoplasmic reticulum (ER) targeting sequence KDEL. Does not cross-react with human endoplasmic reticulum (ER) targeting sequence KDEL.
APPLICATION:
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
ER-Golgi Intermediate Compartment [ERGIC] / Related Products
•
Polyclonal Antibodies
ALX-210-142
Revised 12-Jun-06
Polyclonal Antibody to FKBP12
SYNONYMS
anti-FK506 Binding Protein (12kDa) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-142-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-13 (G
1
VQVETISPGDGR
13
) of human FKBP12 (FK506 binding protein 12kDa).
SPECIFICITY:
Recognizes human, mouse and rat FKBP12. Detects a band of ~12kDa by Western blot.
APPLICATION:
Immunohistochemistry (frozen sections (2µg/ml); paraffin sections)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-002
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The effects of FK506 on retinal ganglion cells after optic nerve crush:
E.E. Freeman and C.L. Grosskreutz; IOVS
41
, 1111 (2000)
Abstract
Immunophilin expression in the HIV-infected brain:
C.L. Achim, et al.; J. Neuroimmunol.
157
, 126 (2004)
Abstract
Related Products
ALX-156-002
Blocking Peptide for PAb to FKBP12 (Prod. No.
ALX-210-142
)
Further Categories Containing This Product:
Mammalian Target of Rapamycin [mTOR] / Related Products
•
Polyclonal Antibodies
ALX-210-143/1
Revised 23-Jun-08
Polyclonal Antibody to Ca2+-Sensing Receptor
SYNONYMS
anti-CASR PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
