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ALX-804-213
Revised 14-Feb-08
Monoclonal Antibody to Apurinic/Apyrimidinic Endonuclease (human) (13B 8E5C2)
SYNONYMS
anti-APE1 (human) MAb (13B 8E5C2)
anti-APEX (human) MAb (13B 8E5C2)
anti-HAP1 (human) MAb (13B 8E5C2)
anti-Ref-1 (human) MAb (13B 8E5C2)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA Endonucleases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-213-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
13B 8E5C2
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human APE1 (apurinic/apyrimidinic endonuclease).
SPECIFICITY:
Recognizes human APE1. Detects a band of ~37kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections (1:100))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer:
M.R. Kelley, et al.; Clin. Cancer Res.
7
, 824 (2001)
Abstract
Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers:
D.H. Moore, et al.; Clin. Cancer Res.
6
, 602 (2000)
Abstract
General Information
Mammalian apurinic/apyrimidinic (AP) endonuclease (APE1; APEX; HAP1; Ref-1) is a multifunctional, bipartite enzyme that belongs to the class II AP endonucleases and that plays an important role in numerous, cellular functions, like repairing abasic sites (loss of purine or pyrimidine base) in DNA, regulating the redox state of other proteins that play roles in oxidative signalling, transcription factor regulation (Fos, Jun, NF-κ B, Myb, HIF-1α, CREB, Pac), cell cycle control (p53) and apoptosis. APE1 initiates the DNA base excision repair (BER) by cleaving the DNA immediately adjacent to the 5’ of an AP site to produce a hydroxyl group at the 3’ terminus of an unmodified nucleotide upstream of the nick and a 5’-deoxyribose phosphate moiety downstream. The product of APE1 is further processed by DNA polymerase β to release 5’-deoxyribose phosphate with its intrinsic lyase activity. The nicked DNA is then sealed by DNA ligase I or DNA ligaseIII/XRCC1 to complete this repair process. In addition to the AP endonuclease activity, APE1 also possesses a 3’-5’ DNA exonuclease activity, a 3’-phosphodiesterase activity, a 3’-phosphatase activity, and a RNase H activity. Recently it has been shown that APE1 is capable of excision L-configuration deoxyribonucleoside analogs from the 3’ termini of DNA. Human APE1 gene is located on chromosome 14q 11.2-12.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-020
Revised 01-Jul-08
Monoclonal Antibody to ART1 (human) (GUGU1-A3)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 1 (human) MAb (GUGU1-A3)
anti-CD296 (human) MAb (GUGU1-A3)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-020-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
GUGU1-A3
ISOTYPE:
Rat IgG2b
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of human ART1 (ecto-ADP-ribosyltransferase 1; CD296).
SPECIFICITY:
Recognizes human ART1.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte, et al.; Cell. Immunol.
236
, 66 (2005)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Di Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling
: M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte, et al.; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-028
Revised 01-Jul-08
Monoclonal Antibody to ART1 (mouse) (NOGU1-A111)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 1 (mouse) MAb (NOGU1-A111)
anti-CD296 (mouse) MAb (NOGU1-A111)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-028-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
NOGU1-A111
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse ART1 (ecto-ADP-ribosyltransferase 1; CD296).
SPECIFICITY:
Recognizes mouse ART1.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte, et al.; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-021
Revised 01-Jul-08
Monoclonal Antibody to ART2.1 (mouse) (GUGU2-B54)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 2.1 (mouse) MAb (GUGU2-B54)
anti-ART2a (mouse) MAb (GUGU2-B54)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-021-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
GUGU2-B54
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse ART2.1 (ecto-ADP-ribosyltransferase 2.1; ART2a).
SPECIFICITY:
Recognizes mouse ART2.1.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte, et al.; Cell. Immunol.
236
, 66 (2005)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte, et al.; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-022
Revised 01-Jul-08
Monoclonal Antibody to ART2.2 (mouse) (NIKA-102)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 2.2 (mouse) MAb (NIKA-102)
anti-ART2b (mouse) MAb (NIKA-102)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-022-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
NIKA-102
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse ART2.2 (ecto-ADP-ribosyltransferase 2.2; ART2b).
SPECIFICITY:
Recognizes mouse ART2.2.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
A new monoclonal antibody detects a developmentally regulated mouse ecto-ADP-ribosyltransferase on T cells: subset distribution, inbred strain variation, and modulation upon T cell activation:
F. Koch-Nolte, et al.; J. Immunol.
163
, 6014 (1999)
Abstract
;
Full Text
Metalloprotease-mediated shedding of enzymatically active mouse ecto-ADP-ribosyltransferase ART2.2 upon T cell activation:
S. Kahl, et al.; J. Immunol.
165
, 4463 (2000)
Abstract
;
Full Text
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte, et al.; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-023
Revised 19-Oct-06
Monoclonal Antibody to ART3 (human) (GUGU3-A51)
SYNONYMS
anti-ecto-ADP-ribosyltransferase (human) MAb (GUGU3-A51)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-023-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
GUGU3-A51
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of human ART3 (ecto-ADP-ribosyltransferase 3).
SPECIFICITY:
Recognizes human ART3.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte, et al.; Cell. Immunol.
236
, 66 (2005), (Review)
Abstract
Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes:
M. Friedrich, et al.; Asian J. Androl.
8
, 281 (2006)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Di Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte, et al.; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-024
Revised 19-Oct-06
Monoclonal Antibody to ART3 (mouse) (GUGU3-A34)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 3 (mouse) MAb (GUGU3-A34)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-024-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
GUGU3-A34
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse ART3 (ecto-ADP-ribosyltransferase 3).
SPECIFICITY:
Recognizes mouse ART3.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte, et al.; Cell. Immunol.
236
, 66 (2005)
Abstract
Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes:
M. Friedrich, et al.; Asian J. Androl.
8
, 281 (2006)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Di Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells:
F. Koch-Nolte; Ann. Med.
38
, 188 (2006), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-025
Revised 01-Jul-08
Monoclonal Antibody to ART4 (human) (NONI-B4)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 4 (human) MAb (NONI-B4)
anti-CD297 (human) MAb (NONI-B4)
anti-DO (human) MAb (NONI-B4)
anti-Dombrock Blood Group Carrier Molecule (human) MAb (NONI-B4)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-025-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
NONI-B4
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of human ART4 (ecto-ADP-ribosyltransferase 4; CD297).
SPECIFICITY:
Recognizes human ART4.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte; Cell. Immunol.
236
, 66 (2005)
Abstract
A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens:
I. Parusel, et al.; Cell Immunol.
236
, 59 (2005)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Di Girolamo; EMBO J.
22
, 1953 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
Complexities of the Dombrock blood group system revealed:
M.E. Reid; Transfusion
45
, 92S (2005)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-802-026
Revised 01-Jul-08
Monoclonal Antibody to ART4 (mouse) (GUGU4-A53)
SYNONYMS
anti-ecto-ADP-ribosyltransferase 4 (mouse) MAb (GUGU4-A53)
anti-CD297 (mouse) MAb (GUGU4-A53)
anti-DO (mouse) MAb (GUGU4-A53)
anti-Dombrock Blood Group Carrier Molecule (mouse) (GUGU4-A53)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-802-026-L001
1 ml
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
GUGU4-A53
ISOTYPE:
Rat IgG2a
FORMULATION:
Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN:
Vector containing the cDNA of mouse ART4 (ecto-ADP-ribosyltransferase 4; CD297).
SPECIFICITY:
Recognizes mouse ART4.
APPLICATION:
Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation:
F. Koch-Nolte, et al.; Cell. Immunol.
236
, 66 (2005)
Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation:
D. Corda & M. Di Girolamo; EMBO J.
1953
, 22 (2003), (Review)
Abstract
;
Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling:
M. Seman, et al.; Curr. Med. Chem.
11
, 857 (2004), (Review)
Abstract
Complexities of the Dombrock blood group system revealed:
M.E. Reid; Transfusion
45
, 92S (2005), (Review)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-421
Revised 26-Nov-04
Monoclonal Antibody to Aryl Hydrocarbon Receptor (RPT1)
SYNONYMS
anti-AhR MAb (RPT1)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Aryl Hydrocarbon Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-421-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE:
RPT1
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Ascites containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 12-17 (R
12
KRRKP
17
) and aa 22-31 (V
22
KPIPAEGIK
31
) of mouse AhR (aryl hydrocarbon receptor).
SPECIFICITY:
Recognizes human, mouse and rat AhR. Detects a band of ~95kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
For immunoprecipitation, use MAb to AhR (RPT9) (Prod. No.
ALX-804-423
)
.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex
:
H.S. Chen & G.H. Perdew; J. Biol. Chem.
269
, 27554 (1994)
Abstract
;
Full Text
General Information
The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor.
Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-423
Revised 12-Jun-08
Monoclonal Antibody to Aryl Hydrocarbon Receptor (RPT9)
