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Kinases / Related Products
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ALX-350-006 Revised 05-Apr-08
Genistein (synthetic)
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SYNONYMS 4',5,7-Trihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-006-M010   10 mg 25.00 USD Add To Cart
ALX-350-006-M025   25 mg 50.00 USD Add To Cart
ALX-350-006-M050   50 mg 90.00 USD Add To Cart
ALX-350-006-M100   100 mg 150.00 USD Add To Cart
ALX-350-006-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 446-72-0
MERCK INDEX: 14: 4391
RTECS: NR2392000
SOURCE/HOST: Synthetic.
PURITY: ≥99% (HPLC)
APPEARANCE: White to yellow crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990) Abstract
Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002) Abstract
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review Abstract
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004) Abstract
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • TNF-alpha & TNF Receptors Other Products • Cell Cycle Blockers & Inhibitors / Related Products • EGFR Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antitumor Reagents • Active Substances from Fruit and Vegetables • Antitumor Agents (Apoptosis Inducers) • Natural Products for Cell Cycle Research • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Isoflavones • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-247 Revised 27-Oct-08
Genistin
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SYNONYMS Genistein-7-O-glucoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-247-M010   10 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H20O10
MW: 432.4
CAS NUMBER: 529-59-9
MERCK INDEX: 14: 4391
RTECS: DJ3093000
PURITY: ≥98%
APPEARANCE: Off-white to light yellow powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Glucoside of genistein (Prod. No. ALX-350-006) found in soy beans. Useful as a negative control for genistein and other tyrosine kinase inhibitors. Selective inhibitor of terminal deoxyribonucleotidyltransferase (TdT). Displays antioxidant and anticarcinogenic properties.
Product Specific Literature References
Soybean isoflavones, genistein and genistin, inhibit rat myoblast proliferation, fusion and myotube protein synthesis: S. Ji, et al.; J. Nutr. 129, 1291 (1999) Abstract
Daidzein and genistein but not their glucosides are absorbed from the rat stomach: M.K. Piskula, et al.; FEBS Lett. 447, 287 (1999) Abstract
Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones: H.G. Shertzer, et al.; Chem. Biol. Interact. 123, 31 (1999) Abstract
Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin: Y. Uchiyama, et al.; Biochim. Biophys. Acta 1725, 298 (2005) Abstract
Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells: A. Russo, et al.; J. Nutr. Biochem. 17, 103 (2006) Abstract
Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells: E.J. Choi, et al.; Life Sci. 80, 1403 (2007) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Isoflavones
 
 
ALX-157-014 Revised 14-Dec-04
H-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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ALX-157-014-M001   1 mg 50.00 USD Add To Cart
ALX-157-014-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C34H64N14O11
MW: 845.0
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for cAMP-dependent protein kinase (PKA). The peptide corresponds to the amino acid sequence 106-113 of the human myelin basic protein.
Product Specific Literature References
Synthetic substrate for cyclic AMP-dependent protein kinase: P. Daile, et al.; Nature 257, 416 (1975) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-013 Revised 04-Jul-03
[Ala9,10, Lys11,12]-Glycogen Synthase (1-12)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-013-M001   1 mg 80.00 USD Add To Cart
ALX-157-013-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys-OH
FORMULA: C56H103N17O16
MW: 1270.5
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC). Peptide comprising the amino acid sequence of the glycogen synthase phosphorylation site.
Product Specific Literature References
The influence of basic residues on the substrate specificity of protein kinase C: C. House, et al.; J. Biol. Chem. 262, 772 (1987) Abstract; Full Text
A tandem chromatographic column method for assaying cAMP-dependent protein kinase and protein kinase C with synthetic peptide substrates: J.J. Egan, et al.; Anal. Biochem. 175, 552 (1988) Abstract
A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes: D.R. Alexander, et al.; Biochem. J. 260, 893 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-850-005 Revised 24-Feb-05
cGMP EIA Kit
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG Kits
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-005-KI01   1 Kit 412.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the measurement of cGMP.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • ELISA & EIA Kits
 
 
ALX-202-049 Revised 14-Jun-05
cGMP-dependent Protein Kinase Iα (bovine)
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SYNONYMS Protein Kinase G Iα (bovine)
cGK Iα (bovine)
PKG Iα (bovine)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
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ALX-202-049-C005   5 µg 310.00 USD Add To Cart
Product Specification
MW: ~74kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Native protein isolated from bovine lung.
CONCENTRATION: 100µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 10mM phosphate buffer, pH 6.8, containing 1mM EDTA, 15mM β-mercaptoethanol, 10U/ml Trasylol and 50% glycerol.
SPECIFIC ACTIVITY: 2U/mg protein. 10-fold stimulation by cGMP (5µM). One unit is defined as 1µmol/min/mg using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Immunological distinction between guanosine 3':5'-monophosphate- dependent and adenosine 3':5'-monophosphate-dependent protein kinases: U. Walter, et al.; J. Biol. Chem. 255, 3757 (1980) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P00516: cGMP-dependent Kinase Ia (bovine)
AfCS Signalling Gateway link A000043: cGMP-dependent Kinase I (mouse)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-201-071 Revised 12-Jul-06
cGMP-dependent Protein Kinase Iβ (human) (recombinant)
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SYNONYMS Protein Kinase G Iβ (human) (recombinant)
cGK Iβ (bovine) (recombinant)
PKG Iβ (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-071-C005   5 µg 320.00 USD Add To Cart
Product Specification
MW: ~76kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Produced in Sf9 cells [1].
CONCENTRATION: 50µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 1mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol and 50% glycerol.
SPECIFIC ACTIVITY: ~1.5-5U/mg protein. 25-fold stimulation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice at all times. Enzyme loses activity during a single freeze/thaw cycle.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
[1] Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system: D. Pöhler, et al.; FEBS Lett. 374, 419 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P14619: PKG Iβ (human)
AfCS Signalling Gateway link A000043: PKG I (mouse)
Further Categories Containing This Product:
Enzymes • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-072 Revised 06-Oct-06
cGMP-dependent Protein Kinase II (rat) (recombinant)
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SYNONYMS PKG II (rat) (recombinant)
cGK II (rat) (recombinant)
Protein Kinase G II (rat) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-072-C005   5 µg 320.00 USD Add To Cart
Product Specification
MW: ~86kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Produced in Sf9 cells [1].
CONCENTRATION: 50µg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 5mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol, 0.015% NP40 and 50% glycerol.
SPECIFIC ACTIVITY: ~0.5-2.0U/mg protein. 5-fold activation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES (pH 7.4), 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: The enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice (0-4°C) at all times. The enzyme loses activity during a single freeze/thaw cycle.
To avoid adherence of the product to plastic, the use of siliconized vials and tips is recommended.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
[1] Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system: D. Pöhler, et al.; FEBS Lett. 374, 419 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q64595: cGMP-dependent Kinase II (rat)
AfCS Signalling Gateway link A000044:  cGMP-dependent Kinase II (mouse)
Further Categories Containing This Product:
Enzymes • Recombinant Proteins / Fusion Proteins
 
 
ALX-270-021 Revised 03-Jul-08
Gö 6976
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SYNONYMS 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-021-MC05   0.5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C24H18N4O
MW: 378.4
CAS NUMBER: 136194-77-9
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3-4 months when  stored at -20°C.
HANDLING: Protect from light.

Product Description
Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β and γ). Potent antagonist of HIV-1 induction.
Product Specific Literature References
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett 3, 1959 (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem. 268, 9194 (1993) Abstract; Full Text
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS 90, 4674 (1993) Abstract
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC 200, 1536 (1994) Abstract
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996) Abstract
 
 
ALX-350-113 Revised 28-May-08
Gossypol
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SYNONYMS 2,2’-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-
methylnaphthalene]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-113-M100   100 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C30H30O8
MW: 518.6
CAS NUMBER: 303-45-7
MERCK INDEX: 14: 4528
RTECS: DU3100000
SOURCE/HOST: Isolated from Gossypium genus, Malvaceae.
PURITY: ≥90%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in acetone or DMSO; sparingly soluble in 100% ethanol (2mg/ml) or methanol (2mg/ml). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor.