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Natural Products - Anti-inflammatory Agents
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ALX-350-376 Revised 22-Jul-08 New product
Scytonemin
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SYNONYMS SCY
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-376-M001   1 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C36H20N2O4
MW: 544.6
CAS NUMBER: 152075-98-4
SOURCE/HOST: Isolated from Lyngbya sp.
PURITY: ≥85% (HPLC)
APPEARANCE: Brown solid.
SOLUBILITY: Soluble in DMSO (25mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months at -20°C.
HANDLING: Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light.

Product Description
Cell permeable, dimeric indolo-phenol kinase inhibitor. Has anti-proliferative and anti-inflammatory properties. Ultraviolet sunscreen pigment.
Product Specific Literature References
The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria: P.J. Proteau, et al.; Experientia 49, 825 (1993) Abstract
Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases: C.S. Stevenson, et al.; Inflamm. Res. 51, 112 (2002) Abstract
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore: C.S. Stevenson, et al.; J. Pharmacol. Exp. Ther. 303, 858 (2002) Abstract; Full Text
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Marine Natural Products
 
 
ALX-350-383 Revised 29-Sep-08 New product
Genipin
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SYNONYMS (+)-Genipin
Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Antidiabetic Agents / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-383-M025   25 mg 65.00 USD Add To Cart
ALX-350-383-M100   100 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C11H14O5
MW: 226.2
CAS NUMBER: 6902-77-8
RTECS: GY5828000
SOURCE/HOST: Isolated from Gardenia jasminoides Ellis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO (50mg/ml), dimethyl formamide (25mg/ml), 100% ethanol (5mg/ml), methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic.
Product Specific Literature References
Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway: B.C. Kim, et al.; Biochem. Pharmacol. 70, 1398 (2005) Abstract
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets: C.Y Zhang, et al.; Cell Metab. 3, 417 (2006) Abstract
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity: L.E. Parton, et al.; Nature 449, 228 (2007) Abstract
Further Categories Containing This Product:
Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-385-001 Revised 08-Apr-08
Quercetin . dihydrate
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SYNONYMS 3,3',4',5,7-Pentahydroxyflavone . 2H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-001-G005   5 g 15.00 USD Add To Cart
ALX-385-001-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O7 . 2H2O
MW: 302.2 . 36.0
CAS NUMBER: 6151-25-3
MERCK INDEX: 14: 8034
RTECS: LK8950000
SOURCE/HOST: Isolated from Sophora japonica L.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder with a green or brown cast.
SOLUBILITY: Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.

Product Description
Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.
Product Specific Literature References
Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles: D.R. Lang & E. Racker; Biochim. Biophys. Acta 333, 180 (1974)
Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase: A. Beretz, et al.; Experientia 34, 1054 (1978) Abstract
Flavonoids are selective cyclic GMP phosphodiesterase inhibitors: M. Ruckstuhl, et al.; Biochem. Pharmacol. 28, 535 (1979) Abstract
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo: Y. Graziani, et al.; Eur. J. Biochem. 135, 583 (1983) Abstract
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin: M. Gschwendt, et al.; BBRC 117, 444 (1983) Abstract
Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin: J. Levy, et al.; BBRC 123, 1227 (1984) Abstract
The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy: H. Grunicke, et al.; Adv. Enzyme Regul. 28, 201 (1989) Abstract
Induction of apoptosis by quercetin: involvement of heat shock protein: Y.Q. Wei, et al.; Cancer Res. 54, 4952 (1994) Abstract
Multiple effects of tyrosine kinase inhibitors on vascular smooth muscle contraction: C.M. Filipeanu, et al.; Eur. J. Pharmacol. 281, 29 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Molecular mechanisms in the antiproliferative action of quercetin: B. Csokay, et al.; Life Sci. 60, 2157 (1997) Abstract
Modulation of the heat-induced activation of mitogen-activated protein (MAP) kinase by quercetin: Y. Nagasaka & K. Nakamura; Biochem. Pharmacol. 56, 1151 (1998) Abstract
Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling: M. Richter, et al.; Nutr. Cancer 34, 88 (1999) Abstract
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line: M. Russo, et al.; FEBS Lett. 462, 322 (1999) Abstract
The effect of quercetin on induction of apoptosis: J. Rzymowska, et al.; Folia Histochem. Cytobiol. 37, 125 (1999) Abstract
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res. 43, 257 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003)
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li and W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Onions: a source of unique dietary flavonoids: R. Slimestad, et al.; J. Agric. Food Chem. 55, 10067 (2007) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - ATPase Inhibitors • Sirtuins / Related Products • Tyrosine Kinase Inhibitors • Fatty Acid Synthase [FAS] / Related Products • Phosphodiesterases / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Anti-inflammatory Agents • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants
 
 
ALX-385-009 Revised 03-Apr-08
Chrysin
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SYNONYMS 5,7-Dihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-009-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H10O4
MW: 254.2
CAS NUMBER: 480-40-0
MERCK INDEX: 14: 2256
RTECS: LK8329050
PURITY: ≥96%
APPEARANCE: Yellow to tan solid.
SOLUBILITY: Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review) Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007) Abstract
Further Categories Containing This Product:
Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents • Natural Products - Antioxidants
 
 
ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
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SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-010-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 67604-48-2
MERCK INDEX: 14: 6424
PURITY: ≥95%
APPEARANCE: Light yellow to tan powder.
SOLUBILITY: Soluble in 100% ethanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Active Substances from Fruit and Vegetables • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • DNA Repair Other Products
 
 
ALX-385-011 Revised 05-Apr-08
(±)-Hesperetin
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SYNONYMS (±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-011-G001   1 g 21.00 USD Add To Cart
Product Specification
FORMULA: C16H14O6
MW: 302.3
CAS NUMBER: 520-33-2
MERCK INDEX: 14: 4670
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats: H. K. Kim, et al.; Clin. Chim. Acta 327, 129 (2003) Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin: J. Cho; Arch. Pharm. Res. 29, 699 (2006) Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin: J. Y. Kim, et al.; Aging Cell 5, 401 (2006) Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21: E.J. Choi; Nutr. Cancer 59, 115 (2007) Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products • Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-385-012 Revised 19-Nov-07
Myricetin
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SYNONYMS 3,3',4',5,5',7-Hexahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-012-M010   10 mg 35.00 USD Add To Cart
ALX-385-012-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H10O8
MW: 318.2
CAS NUMBER: 529-44-2
MERCK INDEX: 14: 6332
RTECS: LK8646000
PURITY: ≥97%
APPEARANCE: Light yellow-green crystals.
SOLUBILITY: Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation. 
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol. 29, 121 (1997), (Review) Abstract
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001) Abstract
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem. 74, 606 (1999) Abstract
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther. 4, 281 (2005) Abstract
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol. 69, 913 (2005) Abstract
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res. 66, 4410 (2006) Abstract
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis 28, 1918 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-385-015 Revised 12-Aug-08
Peonidin chloride
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SYNONYMS 3,4',5,7-Tetrahydroxy-3'-methoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
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ALX-385-015-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C16H13O6Cl
MW: 336.7
CAS NUMBER: 134-01-0
MERCK INDEX: 14: 7143
PURITY: ≥99% (HPLC)
APPEARANCE: Beige to reddish-brown solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and chemopreventive properties.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2: J.Y. Kwon, et al.; Ann. N. Y. Acad. Sci. 1095, 513 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents
 
 
ALX-385-016 Revised 02-Jun-08
Morin
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SYNONYMS 2’,3,4’,5,7-Pentahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-016-G001   1 g 16.00 USD Add To Cart
Product Specification
FORMULA: C15H10O7
MW: 302.2
CAS NUMBER: 480-16-0
MERCK INDEX: 14: 6269
RTECS: LK8749000
PURITY: ≥85%
APPEARANCE: White to brown powder.
SOLUBILITY: Soluble in methanol or 100% ethanol; slightly soluble in ether or acetic acid.
SHIPPING: AMBIENT </