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Hepatitis Viruses / Related Products
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ALX-804-278 Revised 31-Oct-06
Monoclonal Antibody to Hepatitis Bx Protein (X36C)
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SYNONYMS anti-HBx Protein MAb (X36C)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-278-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE: X36C
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant HBx protein (hepatitis Bx protein).
SPECIFICITY: Recognizes HBx. Detects a band of ~17kDa by Western blot.
APPLICATION: ELISA
Immunoprecipitation (does not immunoprecipitate HBx complexed with XIP)
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-277 Revised 14-Dec-06
Monoclonal Antibody to Hepatitis C Core Protein (C7-50)
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PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-277-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
CLONE: C7-50
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified HCV (hepatitis C virus) core fusion protein (genotype 1b).
SPECIFICITY: Recognizes epitope between aa 21-40 of HCV core protein. This sequence is conserved among different HCV strains. Detects a band of ~21kDa by Western blot.
APPLICATION: ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of three novel monoclonal antibodies against hepatitis C virus core protein: D. Moradpour, et al.; J. Med. Virol. 48, 234 (1996) Abstract
General Information
Hepatitis C virus (HCV) is the primary cause of non-A, non-B hepatitis and results in most HCV-infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. The 21kDa core protein of HCV is well conserved among different HCV genotypes and may suppress hepatitis B virus replication in a phosphorylation dependent manner.
BACKGROUND/TECHNICAL INFORMATION Immunocytochemical staining of HCV core protein in transfected chimp hepatocytes yields a staining pattern consistent with cytoplasmic and vesicular staining.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-059 Revised 27-Apr-06
Monoclonal Antibody to NS3 (HCV) (1B6)
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SYNONYMS anti-Nonstructural Protein 3 (HCV) MAb (1B6)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-059-R100   100 µl 360.00 USD Add To Cart
Product Specification
CLONE: 1B6
ISOTYPE: Mouse IgG1
PURITY: Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
SPECIFICITY: Recognizes HCV NS3 (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex.
APPLICATION: Immunocytochemistry (1:50)
Western Blot (1:500)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines: B. Wolk, et al.; J. Virol. 74, 2293 (2000) Abstract; Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins: Dimitrova, et al.; J. Virol. 77, 5401 (2003) Abstract; Full Text
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons: R. Gosert, et al.; J. Virol. 77, 5487 (2003) Abstract; Full Text
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes: D. Moradpour, et al.; J. Virol. 78, 7400 (2004) Abstract; Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005) Abstract; Full Text
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus: E. Meylan, et al.; Nature 437, 1167 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-061 Revised 26-Apr-07
Monoclonal Antibody to NS5B (HCV) (5B-12B7)
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SYNONYMS anti-Nonstructural Protein 5B (HCV) MAb (5B-12B7)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-061-R100   100 µl 360.00 USD Add To Cart
Product Specification
CLONE: 5B-12B7
ISOTYPE: Mouse IgG2a
PURITY: Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY: Recognizes HCV NS5B (epitope mapped to NS5B aa 139-392).
APPLICATION: Immunocytochemistry (1:100)
Immunoprecipitation
Functional Application: Blocks the RNA-dependent RNA polymerase activity in vitro.
Note: Not suitable for Western blot. Use MAb to NS5B (HCV) (5B-3B1) (Prod. No. ALX-803-060).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase: J. Schmidt-Mende, et al.; J. Biol. Chem. 276, 44052 (2001) Abstract; Full Text
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002) Abstract; Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins: Dimitrova, et al.; J. Virol. 77, 5401 (2003) Abstract; Full Text
Interference of hepatitis C virus RNA replication by short interfering RNAs: Kapadia, et al.; PNAS 100, 2014 (2003) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-060 Revised 27-Apr-06
Monoclonal Antibody to NS5B (HCV) (5B-3B1)
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SYNONYMS anti-Nonstructural Protein 5B (HCV) MAb (5B-3B1)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-060-R100   100 µl 360.00 USD Add To Cart
Product Specification
CLONE: 5B-3B1
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY: Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382).
APPLICATION: Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002) Abstract; Full Text
Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells: R.W. Hardy, et al.; J. Virol. 77, 2029 (2003) Abstract; Full Text
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs: G. Randall, et al.; PNAS 100, 235 (2003) Abstract; Full Text
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005) Abstract; Full Text
Quantitative analysis of the hepatitis C virus replication complex: D. Quinkert, et al.; J. Virol. 79, 13594 (2005) Abstract
Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3: Y.V. Svitkin, et al.; J. Virol. 79, 6868 (2005) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation
General Literature References
Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005) Abstract
Related Products
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-201-247 Revised 18-Mar-08
NS3-NS4A (HCV) (recombinant) (His)
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SYNONYMS Nonstructural Protein 3-NS4A (HCV) (recombinant) (His)
Hepacivirin-NS4A (HCV) (recombinant) (His)
PRODUCT LINE Viral Signalling
PRODUCT CATEGORY Hepatitis Viruses / Related Products
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ALX-201-247-C100   100 µg 210.00 USD Add To Cart
Product Specification
MW: ~68.7kDa (NS3 subunit); ~6.2kDa (NS4A subunit)
EC: 3.4.21.98
SOURCE/HOST: Produced in E. coli. Recombinant hepatitis C virus (HCV) NS3-NS4A serine protease complex is fused to a His-tag.
CONCENTRATION: 379ng/μl (5µM)
PURITY: ≥85% (SDS-PAGE)
FORMULATION: Liquid. In 25mM HEPES, pH 7.6, containing 1mM EDTA, 3mM DTT, 0.5M sodium chloride, 0.2% Triton X-100 and 20% glycerol.
BIOLOGICAL ACTIVITY: IC50 (lot-specific)
APPLICATION: Suitable for screenings.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
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