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Cell Cycle
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AG-CC06H2 Revised 11-Jan-08
Clusterin (human) Competitive ELISA Kit
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SYNONYMS TRPM-2 (human) Competitive ELISA Kit
Apolipoprotein J (human) Competitive ELISA Kit
APO-J (human) Competitive ELISA Kit
CLI (human) Competitive ELISA Kit
CLU (human) Competitive ELISA Kit
SGP-2 (human) Competitive ELISA Kit
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
AG-CC06H2EK-KI01   96 wells 550.00 USD Add To Cart
AG-CC06H2TP-KI01 Twin Plex 2x96 wells 890.00 USD Add To Cart
AG-CC06H2PP-KI01 Penta Plex 5x96 wells 1'870.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 1ng/ml
APPLICATION: For the quantitative determination of clusterin in human serum, plasma or cell culture supernatant.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-105-011 Revised 18-Sep-06
S-Trityl-L-cysteine
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SYNONYMS NSC 83265
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-011-M100   100 mg 20.00 USD Add To Cart
ALX-105-011-M500   500 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H21NO2S
MW: 363.5
CAS NUMBER: 2799-07-7
RTECS: AY7710000
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or acetic acid
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC50=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC50=700nM) and inhibits the growth of NCI tumor cell line panel (GI50=1.31µM).
Product Specific Literature References
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities: S. DeBonis, et al.; Mol. Cancer Ther. 3, 1079 (2004) Abstract; Full Text
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression: D.A. Skoufias, et al.; J. Biol. Chem. 281, 17559 (2006) Abstract; Full Text
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products • Antitumor Agents (Anti-proliferative)
 
 
ALX-153-012 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitor
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SYNONYMS CDK2/Cyclin Inhibitor
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-012-M001   1 mg 120.00 USD Add To Cart
ALX-153-012-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Ser-Phe-Val-His-His-Gly-Phe-Phe-Asn-Phe-Arg-Val-Ser-Trp-Arg-Glu-Met-Leu-Ala-OH
FORMULA: C121H164N32O27S
MW: 2530.9
PEPTIDE CONTENT: 75-95%
PURITY: ≥97%
APPEARANCE: White to off-white lyophilized solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Inhibitor of cyclin-dependent kinase 2 (CDK2).
Product Specific Literature References
Genetic selection of peptide aptamers that recognize and inhibit cyclin- dependent kinase 2: P. Colas, et al.; Nature 380, 548 (1996) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-041 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide I
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SYNONYMS CDK2/Cyclin Inhibitory Peptide I
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-041-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly-OH
FORMULA: C111H196N48O23
MW: 2571.1
PURITY: ≥98% (HPLC)
APPEARANCE: Solid.
FORMULATION: Lyophilized. Counter Ion: Trifluoroacetate salt.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Following reconstitution, aliquot and freeze (-20°C). Product is stable for 2 years as supplied. Stock solutions are stable for 3 months at -20°C.
HANDLING: Hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.

Chimeric peptide consisting of the N-terminal sequence of the HIV-TAT protein (directing uptake across the cell membrane) and the consensus sequence PVKRRLFG that serves as the docking site for CDK2/cyclin complexes.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-153-042 Revised 04-Mar-05
Cyclin-dependent Kinase 2 Inhibitory Peptide II
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SYNONYMS CDK2/Cyclin Inhibitory Peptide II
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-153-042-C500   500 µg 145.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Pro-Val-Lys-Arg-Arg-Leu-Asp-Leu-OH
FORMULA: C110H200N48O25
MW: 2595.1
PURITY: ≥98%
APPEARANCE: Lyophilized solid.
SOLUBILITY: Soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.
Product Description
Cell permeable inhibitor of CDK2/cyclin complexes. Blocks phosphorylation of substrates by CDK2/cyclin A and CDK/cyclin E complexes. Preferentially induces apoptosis only in transformed cells and not in non-transformed cells.
Product Specific Literature References
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists: Y.N. Chen, et al.; PNAS 96, 4325 (1999) Abstract; Full Text
Further Categories Containing This Product:
Peptides • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-165-018 Revised 09-Dec-04
Protein Kinase p34cdc2 Substrate
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-018-M001   1 mg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Asp-Ala-Gln-His-Ala-Thr-Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-Glu-Asp-Pro-Lys-Asp-Phe-OH
FORMULA: C106H172N32O32
MW: 2406.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific substrate for p34cdc2 protein kinase, an enzyme involved in mitosis and onset of the S phase.
Product Specific Literature References
Characterization of synthetic peptide substrates for p34cdc2 protein kinase: D.R. Marshak, et al.; J. Cell. Biochem. 45, 391 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-201-221 Revised 02-Oct-06
Pin1 (human) (recombinant)
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SYNONYMS Peptidyl-prolyl cis-trans Isomerase Pin1 (human) (recombinant)
PPIase Pin1 (human) (recombinant)
Peptidyl-prolyl cis-trans Isomerase NIMA-interacting 1 (human) (recombinant)
PPIase NIMA-interacting 1 (human) (recombinant)
Rotamase Pin1 (human) (recombinant)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Alzheimer Research Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-221-C100   100 µg 325.00 USD Add To Cart
Product Specification
MW: ~18.2kDa
SOURCE/HOST: Recombinant human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 5mM DTT and 20% glycerol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Stress & Heat Shock Proteins Other Products • Recombinant Proteins / Fusion Proteins • Antiviral Signalling / Related Products • p53 Other Products
 
 
ALX-201-233 Revised 22-Jun-07
Rad9/Rad1/Hus1 (human) (recombinant)
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SYNONYMS 9-1-1 Complex (human) (recombinant)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY DNA Damage Checkpoint Other Products
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ALX-201-233-C005   5 µg 240.00 USD Add To Cart
Product Specification
MW: 106kDa (heterotrimer of 43, 31 and 32kDa)
SOURCE/HOST: Produced in baculovirus.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (by SDS-PAGE).
FORMULATION: Liquid. In 25mM Tris, pH 8.0, containing 20% glycerol, 100mM sodium chloride and 1mM β-mercaptoethanol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair: M. Toueille, et al.; Nucl. Acids Res. 32, 3316 (2004) Abstract; Full Text
The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery: E. Smirnova, et al.; Biochem. J. 389, 13 (2005) Abstract
General Literature References
Regulation of the DNA replication fork: a way to fight genomic instability: M. Toueille and U. Hubscher; Chromosoma 113, 113 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • DNA Replication Other Products
 
 
ALX-201-234 Revised 07-Nov-07
Proliferating Cell Nuclear Antigen (human) (recombinant)
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SYNONYMS PCNA (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Proliferating Cell Nuclear Antigen [PCNA] / Related Products
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ALX-201-234-C025   25 µg 240.00 USD Add To Cart
Product Specification
MW: 87kDa (homotrimer of 29kDa)
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 50% glycerol, 50mM sodium chloride, 1mM DTT and 1mM EDTA.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 4 weeks when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Specific Literature References
The solution structure of functionally active human proliferating cell nuclear antigen determined by small-angle neutron scattering: P. Schurtenberger, et al.; J. Mol. Biol. 275, 123 (1998) Abstract
General Literature References
Proliferating cell nuclear antigen (PCNA): a dancer with many partners: G. Maga and U. Hubscher; J. Cell Sci. 116, 3051 (2003) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Tumor Markers
 
 
ALX-201-278 Revised 30-Sep-08
DNA Ligase I (human) (recombinant) (His)
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SYNONYMS DNA Ligase 1 (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Replication Other Products
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ALX-201-278-C010   10 µg 260.00 USD Add To Cart
Product Specification
MW: ~102kDa. Note: The mobility of DNA ligase I in a PAA gel is not corresponding to its MW; it runs at ~125kDa.
SOURCE/HOST: Produced in E. coli. Full length human DNA ligase I is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.6mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM HEPES-KOH, pH 7.5, containing 30mM sodium chloride, 1mM EDTA, 1mM DTT and 30% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -80°C
USE/STABILITY: Enzyme is freshly produced upon customer request and is stable for ~2 weeks at -80°C. Very prone to degradation even in the absence of proteases. Freeze in liquid nitrogen for long term storage.
HANDLING: After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Product Specific Literature References
The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair: A. Gembka, et al.; Nucleic Acids Res. 35, 2596 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • DNA Repair Other Products
 
 
ALX-201-296 Revised 15-Oct-08 New product
Replication Protein A (human) (recombinant)
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SYNONYMS RP-A (human) (recombinant)
Replication Factor A (human) (recombinant)
RF-A (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
Ordering Information
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ALX-201-296-C005   5 µg 260.00 USD Add To Cart
Product Specification
MW: ~118kDa (heterotrimer with subunits of 70, 32/34 and 14kDa)
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 0.16mg/ml
PURITY: ≥98% (SDS-PAGE).
FORMULATION: Liquid. In 20mM TRIS, pH 8.0, containing 10% (v/v) glycerol, 2mM EDTA and 1mM DTT.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for more then 2 year when stored at  -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Recombinant replication protein A: expression, complex formation, and functional characterization: L.A. Henricksen, et al.; J. Biol. Chem. 269, 11121 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot links
P27694: RFA1 (human)
P15927: RFA2 (human)
P35244: RFA3 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Pro