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Antibiotics for Cytoskeletal Research
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ALX-350-053 Revised 03-Apr-08
Cytochalasin B, Dihydro-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-350-053-M001   1 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C29H39NO5
MW: 481.6
CAS NUMBER: 39156-67-7
MERCK INDEX: 14: 2790
SOURCE/HOST: Semisynthetic. Derived from cytochalasin B (Prod. No. ALX-380-012), which was isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in or acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Used as tool in cytological research and in characterization of polymerization properties of actin.
Product Specific Literature References
Dihydrocytochalasin B. Biological effects and binding to 3T3 cells: S.J. Atlas & S. Lin; J. Cell. Biol. 76, 360 (1978) Abstract
Microfilament modification by dihydrocytochalasin B causes retinoic acid-modulated chondrocytes to reexpress the differentiated collagen phenotype without a change in shape: P.D. Benya, et al.; J. Cell Biol. 106, 161 (1988) Abstract
Dihydrocytochalasin B enhances transforming growth factor-beta-induced reexpression of the differentiated chondrocyte phenotype without stimulation of collagen synthesis: P.D. Benya & S.R. Padilla; Exp. Cell Res. 204, 268 (1993) Abstract
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways: K. Wenzel-Seifert, et al.; J. Leukoc. Biol. 61, 703 (1997) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Actin / Related Products • Alkaloids
 
 
ALX-350-334 Revised 03-Apr-08
Ascochlorin
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SYNONYMS LL-Z 1272 γ
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-334-MC05   0.5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C23H29ClO4
MW: 404.9
CAS NUMBER: 26166-39-2
RTECS: VH3707560
SOURCE/HOST: Isolated from Acremonium sp. MST-FP1890.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light grey powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antitumor antibiotic. Shows antiviral activity. Inhibitor or matrix metalloproteinase 9 (MMP-9). Reduces the inflammatory response to TNF-α in rat vascular smooth muscle cells. May be useful as an antiatherogenic agent.
Product Specific Literature References
Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I): G. Tamura, et al.; J. Antibiot. (Tokyo) 21, 539 (1968) Abstract
Ascochlorin derivatives as ligands for nuclear hormone receptors: M. Togashi, et al.; J. Med. Chem. 46, 4113 (2003) Abstract
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells: S. Hong, et al.; J. Biol. Chem. 280, 25202 (2005) Abstract; Full Text
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines: K. Sakaguchi, et al.; BBRC 329, 46 (2005) Abstract
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages: J.H. Kang, et al.; J. Cell. Biochem. 102, 506 (2007) Abstract
Further Categories Containing This Product:
MMP Inhibitors • Antibiotics for Cytoskeletal Research • Antibiotics for Inflammation Research • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-380-012 Revised 16-Jun-08
Cytochalasin B
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SYNONYMS Phomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-012-M001   1 mg 35.00 USD Add To Cart
ALX-380-012-M005   5 mg 90.00 USD Add To Cart
ALX-380-012-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C29H37NO5
MW: 479.6
CAS NUMBER: 14930-96-2
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Cell permeable mycotoxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Product Specific Literature References
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972) Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972) Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Review Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse, et al.; Cell Biochem. Funct. 5, 183 (1987) Abstract
Apoptosis induced by adenosine in human leukemia HL-60 cells: Y. Tanaka, et al.; Exp. Cell Res. 213, 242 (1994) Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos, et al.; Biochem. Pharmacol. 47, 1875 (1994) Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky, et al.; Life Sci. 66, 271 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Actin / Related Products • Alkaloids
 
 
ALX-380-031 Revised 29-Apr-08
Cytochalasin D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-031-M001   1 mg 60.00 USD Add To Cart
ALX-380-031-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-77-0
MERCK INDEX: 14: 2790
RTECS: GZ4850000
SOURCE/HOST: Isolated from Zygosporium mansonii.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methylene chloride (10mg/ml); slighly soluble in DMSO (2mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Is ~10-fold more potent than cytochalasin B (Prod. No. ALX-380-012) in inhibiting actin filament function, but does not inhibit sugar transport in cells. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.
Product Specific Literature References
Antitumor activity of cytochalasin D: K. Katagiri & S. Matsuura; J. Antibiot. (Tokyo) 24, 722 (1971) Abstract
Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell. Biol. 105, 1473 (1987) Abstract
Cytochalasin D modulates CD4 crosslinking sensitive mitogenic signal in T lymphocytes: A. Aszalos, et al.; Cell Immunol. 157, 81 (1994) Abstract
Involvement of actin cytoskeleton in modulation of apical K channel activity in rat collecting duct: W.H. Wang, et al.; Am. J. Physiol. 267, F592 (1994) Abstract
Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells: H. Sasaki, et al.; PNAS 92, 2026 (1995) Abstract
Signaling pathways involved in thrombin-induced cell protection: F.M. Donovan & D.D. Cunningham; J. Biol. Chem. 273, 12746 (1998) Abstract; Full Text
The role of actin-binding protein 280 in integrin-dependent mechanoprotection: M. Glogauer, et al.; J. Biol. Chem. 273, 1689 (1998) Abstract; Full Text
Disruption of actin microfilaments by cytochalasin D leads to activation of p53: S.N. Rubtsova, et al.; FEBS Lett. 430, 353 (1998) Abstract
Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin: J.B. Huang, et al.; Cell Immunol. 218, 95 (2002) Abstract
Human chorionic gonadotropin and decidualization in vitro inhibits cytochalasin-D-induced apoptosis in cultured endometrial stromal fibroblasts: A. Jasinska, et al.; Endocrinology 147, 4112 (2006) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Antibiotics - Apoptosis Inducers & Inhibitors • Alkaloids • Antitumor Antibiotics
 
 
ALX-380-057 Revised 03-Apr-08
Cytochalasin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-057-M001   1 mg 50.00 USD Add To Cart
ALX-380-057-M005   5 mg 170.00 USD Add To Cart
ALX-380-057-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C29H35NO5
MW: 477.6
CAS NUMBER: 14110-64-6
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Helminthosporium dematioideum.
PURITY: ≥98% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Fungal toxin. Inhibits glucose transport, actin polymerisation and blocks the formation of microtubuli. Inhibits cell division. Inhibits HIV-1 protease.
Product Specific Literature References
The action of cytochalasin A on the in vitro polymerization of brain tubulin and muscle G-actin: R.H. Himes & L.L. Houston; J. Supramol. Struct. 5, 81 (1976) Abstract
Cytochalasin A inhibits B-lymphocyte capping and activation by antigens: G. Teti, et al.; Immunol. Lett. 3, 151 (1981) Abstract
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activity: R.B. Lingham, et al.; J. Antibiot. 45, 686 (1992) Abstract
Effect of cytochalasin A on apical growth, actin cytoskeleton organization and enzyme secretion in Aspergillus nidulans: S. Torralba, et al.; Microbiology 144 (Pt 1), 45 (1998) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Mycotoxins • Alkaloids
 
 
ALX-380-062 Revised 03-Apr-08
Cytochalasin E
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-062-M001   1 mg 40.00 USD Add To Cart
ALX-380-062-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C28H33NO7
MW: 495.6
CAS NUMBER: 36011-19-5
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Aspergillus clavatus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibits angiogenesis and tumor growth. Depolymerizes actin filaments.
Product Specific Literature References
Inhibition of actin polymerization in blood platelets by cytochalasins: J.E. Fox & D.R. Phillips; Nature 292, 650 (1981) Abstract
Cytochalasin-E-Resistant Mutants of Coprinus cinereus: Isolation and Genetic, Biochemical, and Cytological Analyses: M. Tsukamoto, et al.; Fungal Genet. Biol. 20, 52 (1996) Abstract
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth: T. Udagawa, et al.; J. Pharmacol. Exp. Ther. 294, 421 (2000) Abstract
Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the HeLa epithelial cell line: N. Ikewaki, et al.; Microbiol. Immunol. 47, 775 (2003) Abstract
Further Categories Containing This Product:
Interleukins Other Products • Antibiotics for Angiogenesis Research • Microtubule Modulators • Antitumor Antibiotics • Actin / Related Products • Alkaloids
 
 
ALX-380-069 Revised 26-Jun-08
Cytochalasin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-069-M001   1 mg 60.00 USD Add To Cart
ALX-380-069-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C30H37NO6
MW: 507.6
CAS NUMBER: 22144-76-9
MERCK INDEX: 14: 2790
RTECS: HA5300500
SOURCE/HOST: Isolated from Metarhizium anisopliae.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE TERATOGENIC. VERY TOXIC.

Product Description
Antibiotic. Disrupts the actin microfilament cytoskeleton and inhibits the cytoplasmic dividing of a cell. Has been found to be ten times less toxic in mice than cytochalasin D (Prod. No. ALX-380-031) but with essentially the same biological effectiveness against cells in culture.
Product Specific Literature References
Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery: E.A. Walling, et al.; Arch. Biochem. Biophys. 264, 321 (1988) Abstract
Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts: M. Varedi, et al.; J. Invest. Dermatol. 104, 118 (1995) Abstract
Further Categories Containing This Product:
Microtubule Modulators • Alkaloids
 
 
ALX-380-090 Revised 12-Mar-08
Tryprostatin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
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ALX-380-090-C500   500 µg 179.00 USD Add To Cart
Product Specification
FORMULA: C22H27N3O3
MW: 381.5
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥90%
APPEARANCE: White powder.
SOLUBILITY: Soluble in methanol, 100% ethanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Diketopiperazine. Arrests cell cycle progression at the G2/M phase. Inhibitor of MAP-dependent microtubule assembly. Inhibits the ABC-transporter breast cancer resistance protein (BCRP) and thereby reverses the resistance of cancer cells against antitumor drugs.
Product Specific Literature References
Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus: C.B. Cui, et al.; J. Antibiot. 48, 1382 (1995) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot. 49, 527 (1996) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures: C.B. Cui, et al.; J. Antibiot. 49, 534 (1996) Abstract
Tryprostatin A, a specific and novel inhibitor of microtubule assembly: T. Usui, et al.; Biochem. J. 333, 543 (1998) Abstract; Full Text
Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A: H. Woehlecke, et al.; Int. J. Cancer 107, 721 (2003) Abstract
Further Categories Containing This Product:
Breast Cancer Resistance Protein [BCRP / MXR] / Related Products • Microtubule Modulators • Other Antibiotics for Cancer Research • Antibiotics for Cell Cycle Research • MDR Inhibitors
 
 
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