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ALX-210-197/1
Revised 09-Jul-07
Polyclonal Antibody to Cannabinoid Receptor 1 (NT)
SYNONYMS
anti-CB
1
(NT) PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-197/1-1
1 Vial
356.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-14 (M
1
KSILDGLADTTFR
14
) of the N-terminal extracellular region of human CB
1
(cannabinoid receptor 1). This sequence is completely conserved in mouse and rat.
SPECIFICITY:
Recognizes human, mouse and rat CB
1
. Does not cross-react with CB
2
. Detects a band of ~60kDa by Western blot.
APPLICATION:
Western Blot
Note:
Does not work for immunohistochemistry (frozen sections).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-026
.
Product Specific Literature References
Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies:
A.C. Howlett, et al.; Mol. Pharmacol.
53
, 504 (1998)
Abstract
CB1 cannabinoid receptor: cellular regulation and distribution in N18TG2 neuroblastoma cells:
H.H. McIntosh, et al.; Mol. Brain Res.
53
, 163 (1998)
Abstract
Related Products
ALX-153-026
Blocking Peptide for PAb to Cannabinoid Receptor 1 (Prod. No.
ALX-210-197/1
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-198
Revised 28-Jul-08
Polyclonal Antibody to Cannabinoid Receptor 2
SYNONYMS
anti-CB
2
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-198-1
1 Vial
412.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In 500μl TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 20-33 (N
20
PMKDYMIL
SGPQK
33
) of N-terminal human CB
2
(cannabinoid receptor 2).
SPECIFICITY:
Recognizes human and mouse CB
2
. Detects a band of ~45kDa by Western blot. Does not cross-react with CB
1
.
APPLICATION:
Immunohistochemistry (paraffin sections (1:200))
Western Blot (2µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
POSITIVE CONTROL:
Jurkat T-cell lysate can be used as positive control.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-027
.
Product Description
CB
2
is a G-protein coupled receptor that binds Δ
9
-tetrahydrocannabinol, as well as arachidonyl ethanolamide (endogenous CB receptor ligand; see Prod. No.
ALX-340-029
).
Product Specific Literature References
Molecular characterization of a peripheral receptor for cannabinoids:
S. Munro, et al.; Nature
365
, 61 (1993)
Abstract
Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor:
D. Shire, et al.; Biochim. Biophys. Acta
1307
, 132 (1996)
Abstract
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
:
M.L. Casanova, et al.; J. Clin. Invest.
111
, 43 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-314
Revised 22-Sep-08
Polyclonal Antibody to Cannabinoid Receptor 1
SYNONYMS
anti-CB
1
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-314-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human CB
1
(cannabinoid receptor 1) (aa 1-99).
SPECIFICITY:
Recognizes human and rat CB
1
. Detects a band of ~52kDa by Western blot.
APPLICATION:
Immunocytochemistry (1:1’000)
Immunohistochemistry (paraffin sections, frozen sections)
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Immunocytochemical staining of CB
1
in AtT20 cells transfected with the rat CB1 gene with Prod. No.
ALX-210-314
yields a pattern consistent with plasma membrane staining (see Figure).
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-315
Revised 30-Jun-08
Polyclonal Antibody to Cannabinoid Receptor 2
SYNONYMS
anti-CB
2
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-315-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human CB
2
(cannabinoid receptor 2) (aa 1-33).
SPECIFICITY:
Recognizes human and rat CB
2
. By Western blot detects bands of ~60kDa from human spinal cord homogenate and ~40kDa from RBL2H3 cells, representing different glycosylated forms of CB
2
.
APPLICATION:
Flow Cytometry (1:50)
Immunocytochemistry (1:100)
Immunohistochemistry (frozen sections, paraffin sections (1:100))
Western Blot (1:250)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status
:
N. Rayman, et al.; J. Immunol.
172
, 2111 (2004)
Abstract
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner:
M. Alberich Jorda, et al.; Blood
104
, 526 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-316
Revised 28-Mar-08
Polyclonal Antibody to Cannabinoid Receptor 1
SYNONYMS
anti-CB
1
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-316-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
3.3mg/ml
PURITY DETAIL:
Affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant rat CB
1
(cannabinoid receptor 1) (aa 1-77).
SPECIFICITY:
Recognizes human, mouse, rat, monkey, amphibian, chicken and fish CB
1
. Detects a band of ~60kDa by Western blot representing CB
1
;
also detects less intense bands of ~23kDa, ~72kDa and ~180kDa from rat brain homogenate.
APPLICATION:
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-317/1
Revised 03-Jan-07
Polyclonal Antibody to Cannabinoid Receptor 2
SYNONYMS
anti-CB
2
PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-317/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant rat CB
2
(cannabinoid receptor 2) (aa 1-32).
SPECIFICITY:
Recognizes human and rat CB
2
.
APPLICATION:
Flow Cytometry
Immunocytochemistry (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-418
Revised 01-Jul-08
Polyclonal Antibody to Fatty Acid Amide Hydrolase
SYNONYMS
anti-FAAH PAb
anti-Anandamide Amidohydrolase PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Fatty Acid Amide Hydrolase [FAAH] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-418-1
1 Vial
349.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
QUANTITY:
Sufficient for ten (10x10cm) immunoblots.
CONCENTRATION:
0.4mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 561-579 (C
561
LRFMREVEQ
LMTPQKQPS
579
) of rat C-terminal FAAH (fatty acid amide hydrolase).
SPECIFICITY:
Recognizes human, mouse, rat and ferret FAAH. Detects a band of ~63kDa by Western blot.
APPLICATION:
Immunohistochemistry
Western Blot (~2μg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod No.
ALX-156-005
.
Product Specific Literature References
Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry:
K. Tsou, et al.; Neurosci. Lett.
254
, 137 (1998)
Abstract
Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret:
M.D. Van Sickle, et al.; Gastroenterology
121
, 767 (2001)
Abstract
General Information
Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of biologically significant fatty acid amides, such as the endogenous cannabimimetic agent anandamide (AEA; Prod. No.
ALX-340-029
) and the putative anti-inflammatory agent palmitoylethanolamide (PEA; Prod. No.
ALX-300-146
).
General Literature References
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
:
C.J. Fowler, et al.; Biochem. Pharmacol.
62
, 517 (2001), (Review)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-054
Revised 20-Oct-08
Polyclonal Antibody to Monoacylglycerol Lipase
SYNONYMS
anti-MGL PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-054-1
1 vial
357.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit
PURITY DETAIL:
Affinity-purified IgG.
FORMULATION:
Liquid. In TBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-14 (M
1
PEESSPRRTPQSI
14
) of human monoacylglycerol lipase (MAGL).
SPECIFICITY:
Recognizes human, mouse, rat and bovine MAGL. Detects a band of ~35kDa by Western blot.
APPLICATION:
Immunohistochemistry (formalin-fixed paraffin sections)
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-055
Revised 19-Jun-08
Polyclonal Antibody to Cannabinoid Receptor 1 (CT)
SYNONYMS
anti-CB
1
(CT) PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Cannabinoid Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-055-1
1 vial
412.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
PURITY DETAIL:
Affinity-purified IgG.
FORMULATION:
Liquid. In 500µl TBS, pH 7.4, containing 0.5mg/ml BSA, 50% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 461-472 (M
461
SVSTDTSAEAL
472
) of the C-terminal intracellular region of human CB
1
(cannabinoid receptor 1).
SPECIFICITY:
Recognizes human, mouse and rat CB
1
receptor. Detects a band of ~60kDa by Western blot.
APPLICATION:
Immunohistochemistry (paraffin sections (1:50))
Western Blot (1:200)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year when stored at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-067
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-270-022
Revised 09-Jan-08
AEBSF . hydrochloride
SYNONYMS
4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc
®
SC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-022-M050
50 mg
40.00 USD
ALX-270-022-M250
250 mg
145.00 USD
ALX-270-022-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
8
H
10
FNO
2
S . HCl
MW:
203.2 . 36.5
CAS NUMBER:
30827-99-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No.
ALX-270-184
). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide:
B.R. Baker & H.J. Cory; J. Med. Chem.
14
, 119 (1971)
Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide:
P. Megyeri, et al.; Immunology
86
, 629 (1995)
Abstract
;
Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF:
M. Citron, et al.; Neuron
17
, 171 (1996)
Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor:
Y. Nakabo & M.J. Pabst; J. Leukoc. Biol.
60
, 328 (1996)
Abstract
;
Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds:
V. Diatchuk, et al.; J. Biol. Chem.
272
, 13292 (1997)
Abstract
;
Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening:
P. Megyeri, et al.; Eur. J. Pharmacol.
374
, 207 (1999)
Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis:
R. Buitrago-Rey, et al.; J. Antimicrob. Chemother.
49
, 871 (2002)
Abstract
;
Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes:
N. Wijayanti, et al.; J. Biol. Chem.
280
, 21820 (2005)
Abstract
;
Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression:
T. Hosoi, et al.; Eur. J. Pharmacol.
554
, 8 (2007)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
MAPK Pathway Activators
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-270-091
Revised 02-Jul-04
IMMA
SYNONYMS
Indomethacin morpholinylamide
BML-190
