• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Protein Tyrosine Phosphatases Other Products
You are here: Product Lines > Signal Transduction > Phosphatases / Related Products > Protein Tyrosine Phosphatases / Related Products > Protein Tyrosine Phosphatases Other Products
Toolbar - View Selection
 
Items 11 of 11
ALX-350-144 Revised 03-Apr-08
Bakuchiol
Add to Clipboard
SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C18H24O
MW: 256.4
CAS NUMBER: 10309-37-2
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brownish oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Lipid Peroxidation • Natural Products - Antioxidants
 
 
ALX-430-025 Revised 13-May-03
(-)-p-Bromotetramisole . oxalate
Add to Clipboard
SYNONYMS (-)-(S)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole . oxalate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-025-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C11H11BrN2S . C2H2O4
MW: 283.2 . 90.0
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water, methanol, DMF or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent alkaline phosphatase inhibitor.
 
 
ALX-270-169 Revised 07-Dec-04
Dephostatin
Add to Clipboard
SYNONYMS 2,5-Dihydroxy-N-methyl-N-nitrosoaniline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-169-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O3
MW: 168.2
CAS NUMBER: 151606-30-3
SOURCE/HOST: Synthetic.
PURITY: ≥90%
APPEARANCE: Red to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Competitive protein tyrosine phosphatase inhibitor. Protein S-nitrosating reagent.
Product Specific Literature References
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization: M. Imoto, et al.; J. Antibiot. 46, 1342 (1993) Abstract
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination: H. Kakeya, et al.; J. Antibiot. 46, 1716 (1993) Abstract
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs: T. Watanabe, et al.; J. Antibiot. 48, 1460 (1995) Abstract
Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin: L. Yu, et al.; Bioorg. Med. Chem. Lett. 5, 1003 (1995)
Further Categories Containing This Product:
Nitric Oxide Donors
 
 
ALX-803-057 Revised 31-Oct-06
Monoclonal Antibody to Tyrosine Phosphatase IA-2 (Intracellular Domain) (605-772) (97/4D9)
Add to Clipboard
SYNONYMS anti-PTP IA-2ic (605-772) MAb (97/4D9)
anti-Islet Cell Antigen 512 (Intracellular Domain) (605-772) MAb (97/4D9)
anti-Islet Cell Autoantigen 3 (Intracellular Domain) (605-772) MAb (97/4D9)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-057-C100   100 µg 300.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 97/4D9
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS containing 0.9mg/ml sodium azide.
IMMUNOGEN: Recombinant human IA-2ic (tyrosine phosphatase IA-2 (intracellular domain)).
SPECIFICITY: Recognizes an epitope (aa 605-772) of human, mouse and rat IA-2ic.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-056 Revised 31-Oct-06
Monoclonal Antibody to Tyrosine Phosphatase IA-2 (Intracellular Domain) (618-628) (98/4H6)
Add to Clipboard
SYNONYMS anti-PTP IA-2ic (618-628) MAb (98/4H6)
anti-Islet Cell Antigen 512 (Intracellular Domain) (618-628) MAb (98/4H6)
anti-Islet Cell Autoantigen 3 (Intracellular Domain) (618-628) MAb (98/4H6)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-056-C100   100 µg 300.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 98/4H6
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS containing 0.9mg/ml sodium azide.
IMMUNOGEN: Recombinant human IA-2ic (tyrosine phosphatase IA-2 (intracellular domain)).
SPECIFICITY: Recognizes an epitope (aa 618-628) of human, mouse and rat IA-2ic.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-058 Revised 31-Oct-06
Monoclonal Antibody to Tyrosine Phosphatase IA-2 (Intracellular Domain) (771-979) (103/2C4)
Add to Clipboard
SYNONYMS anti-PTP IA-2ic (771-979) MAb (103/2C4)
anti-Islet Cell Antigen 512 (Intracellular Domain) (771-979) MAb (103/2C4)
anti-Islet Cell Autoantigen 3 (Intracellular Domain) (771-979) MAb (103/2C4)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-058-C100   100 µg 300.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 103/2C4
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS containing 0.9mg/ml sodium azide.
IMMUNOGEN: Recombinant human IA-2ic (tyrosine phosphatase IA-2 (intracellular domain)).
SPECIFICITY: Recognizes an epitope (aa 771-979) of human, mouse and rat IA-2ic.
APPLICATION: Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-021 Revised 29-Jun-05
Polyclonal Antibody to FAP-1 (human) (1729)
Add to Clipboard
SYNONYMS anti-PTND (human) PAb (1729)
anti-Fas-associated Protein-tyrosine Phosphatase 1 (human) PAb (1729)
anti-PTP-E1 (human) PAb (1729)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-021-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 438-453 (E438PTRQENWTPLKNDLE453) of human FAP-1 (Fas-associated protein-tyrosine phosphatase 1).
SPECIFICITY: Recognizes human FAP-1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer: I. Meinhold-Heerlein, et al.; Am. J. Pathol. 158, 1335 (2001) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Fas Signalling Other Products • Polyclonal Antibodies
 
 
ALX-210-020 Revised 24-Mar-05
Polyclonal Antibody to FAP-1 (human) (1730)
Add to Clipboard
SYNONYMS anti-PTND (human) PAb (1730)
anti-Fas-associated Protein-tyrosine Phosphatase 1 (human) PAb (1730)
anti-PTP-E1 (human) PAb (1730)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-020-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Serum containing PBS and 0.05% sodium azide.
IMMUNOGEN: Recombinant human FAP-1 (Fas-associated protein-tyrosine phosphatase 1) (aa 1279-1883).
SPECIFICITY: Recognizes human FAP-1.
APPLICATION: Immunohistochemistry (paraffin sections (1:2'000))
Western Blot (1:3'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer: I. Meinhold-Heerlein, et al.; Am. J. Pathol. 158, 1335 (2001) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Fas Signalling Other Products • Polyclonal Antibodies
 
 
ALX-165-020 Revised 21-Feb-03
Protein Tyrosine Phosphatase Substrate
Add to Clipboard
SYNONYMS Tyrosine Phosphatase Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-020-M001   1 mg 140.00 USD Add To Cart
ALX-165-020-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Thr-Glu-Pro-Glu-Tyr(PO3H2)-Gln-Pro-Gly-Glu-NH2
FORMULA: C45H66N11O21P
MW: 1128.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein tyrosine phosphatases, suitable for continuous fluorimetric assays, based on the effect of phosphate substitution on the intrinsic fluorescence of the dephosphorylated peptide.
Product Specific Literature References
Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases: C. Garcia-Echeverria & D.H. Rich; Bioorg. Med. Chem. Lett. 3, 1601 (1993)
Further Categories Containing This Product:
Peptides
 
 
ALX-350-323 Revised 20-Jun-08
Psoralidin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-323-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 18642-23-4
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound. Cytotoxic against stomach cancer cell lines. Shows antibacterial activity against Shigella sonnei and S. flexneri. Shows strong antioxidant activity and inhibits tyrosine phosphatase 1B (PTP1B) activity. Was shown to possess potent antidepressant properties.
Product Specific Literature References
Influence of nitrogen on accumulation of isosojagol (a newly detected coumestan in soybean) and associated isoflavonoids in roots and nodules of mycorrhizal and non-mycorrhizal soybean: D. Morandi and J.L. Le Quere; New Phytol. 117, 75 (1991) Full Text
The cytotoxicity of psoralidin from Psoralea corylifolia: Y.M. Yang, et al.; Planta Med. 62, 353 (1996) Abstract
Coumarins: A. Estevez-Braun and A.G. Gonzalez; Nat. Prod. Rep. 14, 465 (1997) Abstract
Cytotoxic constituents of Psoralea corylifolia: W. Mar, et al.; Arch. Pharm. Res. 24, 211 (2001) Abstract
Antibacterial compounds from the seeds of Psoralea corylifolia: N.A. Khatune, et al.; Fitoterapia 75, 228 (2004) Abstract
Inducible flavone in oats (Avena sativa) is a novel defense against plant-parasitic nematodes: I. R. Soriano, et al.; Nematology 94, 1207 (2004) Full Text
Antioxidants from a Chinese medicinal herb - Psoralea corylifolia L.: G. Jiangning, et al.; Food Chem. 91, 287 (2005)
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice: L.T. Yi, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 510 (2008) Abstract
Further Categories Containing This Product:
Monoamine Neurotransmitters & Receptors Other Products • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Antioxidants • Natural Products - Other Signal Transduction Pathway Modulators • Protein Tyrosine Phosphatases Other Products
 
 
ALX-380-205 Revised 08-Apr-08
RK-682
Add to Clipboard
SYNONYMS 3-Hexadecanoyl-5-hydroxymethyl-tetronic acid
TAN 1364B
CI 010
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-205-MC05   0.5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H36O5
MW: 368.5
CAS NUMBER: 154639-24-4
SOURCE/HOST: