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ALX-210-792
Revised 25-Feb-08
Polyclonal Antibody to VAMP-2
SYNONYMS
anti-Vesicle-associated Membrane Protein-2 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Vesicle-associated Membrane Proteins [VAMPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-792-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
SATAATVPPAAPAGEGG
18
C) of mouse and rat VAMP-2 (vesicle-associated membrane protein-2).
SPECIFICITY:
Recognizes mouse and rat VAMP-2. Detects a band of ~19kDa by Western blot.
APPLICATION:
Immunoprecipitation
Western Blot (0.3µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-854/1
Revised 06-Oct-06
Polyclonal Antibody to VAMP-3
SYNONYMS
anti-Vesicle-associated Membrane Protein-3 PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Vesicle-associated Membrane Proteins [VAMPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-854/1-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
STGVPSGSSAATGSNRR
18
) of mouse VAMP-3 (vesicle-associated membrane protein-3).
SPECIFICITY:
Recognizes human and rat VAMP-3. Detects a band of ~13kDA by Western blot.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-170-004
.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-857
Revised 01-Dec-04
Polyclonal Antibody to SCAMP2
SYNONYMS
anti-Secretory Carrier Membrane Protein 2 PAb
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Endocytosis
Ordering Information
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Format:
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ALX-210-857-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Purified. Contains 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-17 (M
1
SAFDTNPFADPVDVNP
17
) of human SCAMP2 (secretory carrier membrane protein 2).
SPECIFICITY:
Recognizes mouse and hamster SCAMP 2.
APPLICATION:
Western Blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-167-027
.
Further Categories Containing This Product:
Synaptic Proteins / Related Products
•
Golgi Apparatus
•
Polyclonal Antibodies
ALX-210-859
Revised 21-Aug-07
Polyclonal Antibody to Bcl-XL
SYNONYMS
anti-BCL2L1 PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Bcl-X / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-859-C100
100 µg
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 3-14 of human and mouse Bcl-X
L
and Bcl-X
S
.
SPECIFICITY:
Recognizes human and mouse Bcl-X
L
. Detects a band of ~27kDa by Western blot.
APPLICATION:
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
General Information
Bcl-X has two isoforms, resulting from alternative splicing: Bcl-X
L
(long) is a 241 aa protein (27kD) and Bcl-X
S
is a 178 aa protein with predicted molecular weight of ~19.5kD. Although the peptide immunogen is identical in Bcl-X
L
and Bcl-X
S
, this antibody detects only Bcl-X
L
in Western blot analysis.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-872
Revised 11-Nov-05
Polyclonal Antibody to Bradykinin B2 Receptor
SYNONYMS
anti-B
2
R PAb
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Bradykinin Receptor / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-210-872-R200
200 µl
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Undiluted serum containing 0.01% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 356-391 of human B
2
R (bradykinin B
2
receptor).
SPECIFICITY:
Recognizes human, mouse and rat B
2
R.
APPLICATION:
Immunoprecipitation (use 2-5µl of undiluted antiserum per precipitate)
Western Blot (1:100-1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Ligand-induced phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from human fibroblasts
:
A. Blaukat, et al.; J. Biol. Chem.
271
, 32366 (1996)
Abstract
;
Full Text
Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation
:
A. Blaukat, et al.; Biochemistry
38
, 1300 (1999)
Abstract
Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail
:
A. Pizard, et al.; J. Biol. Chem.
274
, 13738 (1999)
Abstract
;
Full Text
Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function
:
A. Blaukat, et al.; J. Biol. Chem.
276
, 40431 (2001)
Abstract
;
Full Text
Functional specialization of calreticulin domains
:
K. Nakamura, et al.; J. Cell Biol.
154
, 961 (2001)
Abstract
Further Categories Containing This Product:
NOS Regulation
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
Polyclonal Antibodies
ALX-210-883
Revised 02-Apr-07
Polyclonal Antibody to CHIP (human)
SYNONYMS
anti-C-terminus of HSC70 interacting Protein (human) PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Co-Chaperones & HSP-interacting Proteins / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-883-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 218-232 (V
218
DEKRKKRDIPDYLC
232
) of human CHIP (C-terminus of HSC70 interacting protein).
SPECIFICITY:
Recognizes C-terminal human CHIP. Detects bands of ~35kDa (representing CHIP) and ~85kDa (non-specific) by Western blot.
APPLICATION:
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-056
.
Related Products
ALX-153-056
Blocking Peptide for PAb to CHIP (human) (Prod. No.
ALX-210-883
)
Further Categories Containing This Product:
Chaperone-mediated Autophagy [CMA]
•
Polyclonal Antibodies
•
Ubiquitin Ligases [E3]
ALX-210-917
Revised 02-Nov-06
Polyclonal Antibody to SET (human)
SYNONYMS
anti-PHAPII (human) PAb
anti-I
2
α
PP2A
(human) PAb
anti-Phosphatase 2A Inhibitor Protein 2α (human) PAb
anti-HLA-DR-associated Protein 2 (human) PAb
anti-IGAAD (human) PAb
anti-Inhibitor of Granzyme-activated DNase (human) PAb
anti-TAF-Iβ (human) PAb
anti-Template-activating Factor Iβ (human) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-917-C050
50 µg
194.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 3-16 (A
3
PAAKVSKKELNSN
16
) of human SETβ.
SPECIFICITY:
Recognizes human SETβ. Detects endogenous protein by IP and WB.
APPLICATION:
Flow cytometry (1:100-1:200);
Immunocytochemistry;
Immunoprecipitation;
Western blot (1:1'000).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt if stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
:
P.J. Beresford, et al.; J. Biol. Chem.
276
, 43285 (2001)
Abstract
;
Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
:
Z. Fan, et al.; Mol. Cell. Biol.
22
, 2810 (2002)
Abstract
;
Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
:
Z. Fan, et al.; Nat. Immunol.
4
, 145 (2003)
Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
:
Z. Fan, et al.; Cell
112
, 659 (2003)
Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis:
D. Martinvalet, et al.; Immunity
22
, 355 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Granzymes Other Products
•
Polyclonal Antibodies
ALX-210-921
Revised 31-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor (human) (AT101)
SYNONYMS
anti-NGFR (human) PAb (AT101)
anti-TNFRSF 16 (human) PAb (AT101)
anti-p75
NTR
(human) PAb (AT101)
anti-p75 Neurotrophin Receptor (human) PAb (AT101)
anti-CD271 (human) PAb (AT101)
anti-Low-affinity Nerve Growth Factor Receptor (human) PAb (AT101)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-921-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide
IMMUNOGEN:
Recombinant human NGFR (nerve growth factor receptor; p75
NTR
) (Prod. No.
ALX-522-044
).
SPECIFICITY:
Recognizes human NGFR.
APPLICATION:
Western Blot (1:1’000)
Note:
Does not work for Immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells:
A. Tanaka, et al.; BBRC
313
, 1009 (2004)
Abstract
p75NTR--live or let die:
A. Nykjaer, et al.; Curr. Opin. Neurobiol.
15
, 49 (2005)
Abstract
Further Categories Containing This Product:
Neurotensin / Related Products
•
Polyclonal Antibodies
•
CD Antibodies
ALX-210-928
Revised 08-Nov-07
Polyclonal Antibody to LRRK2 (human) (AT106)
SYNONYMS
anti-Leucine-rich Repeat Kinase 2 (human) PAb (AT106)
anti-RIP7 (human) PAb (AT106)
anti-PARK8 (human) PAb (AT106)
anti-Dardarin (human) PAb (AT106)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
RIP Kinases
Ordering Information
Product Numbers:
Format:
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ALX-210-928-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human LRRK2 (leucine-rich repeat kinase 2) (aa 1838-2133).
SPECIFICITY:
Recognizes human LRRK2. The strongest recognized epitope is PDQPRLTIPISQ (aa 1843-1854) as defined by epitope mapping.
APPLICATION:
Immunohistochemistry (paraffin sections (1:500))
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
LRRK2 in Parkinson’s disease and dementia with Lewy bodies:
X. Zhu, et al.; Mol. Neurodegener.
1
, 17 (2006)
Abstract
;
Full Text
General Information
LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease:
C. Paisan-Ruiz, et al.; Neuron
44
, 595 (2004)
Abstract
From The Cover: Parkinson’s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity:
A.B. West, et al.; PNAS
102
, 16842 (2005)
Abstract
The RIP kinases: crucial integrators of cellular stress:
E. Meylan and J. Tschopp; TIBS
30
, 151 (2005)
Abstract
Further Categories Containing This Product:
Parkinson's Disease Other Products
•
Polyclonal Antibodies
ALX-210-930
Revised 26-Feb-07
Polyclonal Antibody to Clusterin (human) (AT109)
SYNONYMS
anti-TRPM-2 (human) PAb (AT109)
anti-Apolipoprotein J (human) PAb (AT109)
anti-APO-J (human) PAb (AT109)
anti-CLI (human) PAb (AT109)
anti-CLU (human) PAb (AT109)
anti-SGP-2 (human) PAb (AT109)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-930-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human clusterin (aa 23-449).
SPECIFICITY:
Recognizes human clusterin.
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Clusterin (human) (recombinant) (Prod.No.
ALX-522-089
)
General Information
Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate
:
J.G. Leger, et al.; BBRC
147
, 196 (1987)
Abstract
Apolipoprotein J: structure and tissue distribution
:
H.V. De Silva, et al.; Biochemistry
29
, 5380 (1990)
Abstract
Clusterin: the intriguing guises of a widely expressed glycoprotein
:
D.E. Jenne & J. Tschopp; Trends Biochem. Sci.
17
, 154 (1992)
Abstract
Clusterin
:
S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol.
34
, 427 (2002), (Review)
Abstract
Clusterin/Apolipoprotein J in human aging and cancer
:
I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol.
34
, 1430 (2002)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
