© 2008 Alexis Corporation
You are here:
Product Lines
>
Chemokines & Cytokines
>
Chemokines & Chemokine Receptors / Related Products
> CXC Chemokines & Receptors / Related Products
ALX-270-478
Revised 30-Jul-08
SB 225002
SYNONYMS
N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-478-M001
1 mg
30.00 USD
ALX-270-478-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
10
BrN
3
O
4
MW:
352.1
CAS NUMBER:
182498-32-4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and
13
C-NMR.
Product Description
Potent and selective antagonist of CXCR2 chemokine receptor (IC
50
=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC
50
=8nM) and GROα-mediated (IC
50
=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Product Specific Literature References
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration:
J.R. White, et al.; J. Biol. Chem.
273
, 10095 (1998)
Abstract
;
Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2:
J. Catusse, et al.; Biochem. Pharmacol.
65
, 813 (2003)
Abstract
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer:
B. Wang, et al.; Cancer Res.
66
, 3071 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
ALX-804-039
Revised 02-Mar-06
Monoclonal Antibody to IL-8 Receptor, Type A (human) (SE 2)
SYNONYMS
anti-Interleukin-8 Receptor, Type A (human) MAb (SE 2)
Monoclonal Antibody to CXCR1 (human) (SE 2)
anti-CXCR1 (human) MAb (SE 2)
anti-CXC Chemokine Receptor 1 (human) MAb (SE 2)
anti-CD181 (human) MAb (SE 2)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-039-C100
100 µg
240.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
SE 2
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in TRIS/glycine containing 0.05% sodium azide.
IMMUNOGEN:
Human IL-8 (interleukin-8) receptor, type A.
SPECIFICITY:
Recognizes purified human IL-8 receptor, type A.
APPLICATION:
Flow Cytometry (10µg/ml)
Immunohistochemistry (acetone fixed frozen sections)
Western Blot
Note:
NOT suitable for neutralizing assay.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
The CXC-chemokine neutrophil-activating peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2
:
A. Ludwig, et al.; Blood
90
, 4588 (1997)
Abstract
;
Full Text
Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid
:
S. Zahn, et al.; Eur. J. Immunol.
27
, 935 (1997)
Abstract
The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils
:
H. Petering, et al.; Blood
93
, 694 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products
•
Monoclonal Antibodies
•
CD Antibodies
ALX-804-040
Revised 02-Mar-06
Monoclonal Antibody to IL-8 Receptor, Type B (human) (HC 2)
SYNONYMS
anti-Interleukin-8 Receptor, Type B (human) MAb (HC 2)
anti-CXCR2 (human) MAb (HC 2)
anti-CXC Chemokine Receptor 2 (human) MAb (HC 2)
anti-CD182 (human) MAb (HC 2)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-040-C100
100 µg
240.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
HC 2
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in TRIS/HCl containing 0.05% sodium azide.
IMMUNOGEN:
Human IL-8 (interleukin-8) receptor, type B.
SPECIFICITY:
Recognizes human IL-8 receptor, type B.
APPLICATION:
Flow Cytometry
Immunohistochemistry (acetone fixed frozen sections)
Western Blot
Note:
NOT suitable for neutralizing assay.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Chemoattractant receptors for interleukin-8 and C5a: expression on peripheral blood leukocytes and differential regulation on HL-60 and AML-193 cells by vitamin D3 and all-trans retinoic acid:
S. Zahn, et al.; Eur. J. Immunol.
27
, 935 (1997)
Abstract
The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils
:
H. Petering, et al.; Blood
93
, 694 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products
•
Monoclonal Antibodies
•
CD Antibodies
ALX-804-592
Revised 31-Jul-07
Monoclonal Antibody to IL-8 Receptor, Type A (human) (X1.53)
SYNONYMS
anti-Interleukin-8 Receptor, Type A (human) MAb (X1.53)
Monoclonal Antibody to CXCR1 (human) (X1.53)
anti-CXCR1 (human) MAb (X1.53)
anti-CXC Chemokine Receptor 1 (human) MAb (X1.53)
anti-CD181 (human) MAb (X1.53)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Receptor Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-592-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
X1.53
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
L1.2 cells expressing human IL-8 (interleukin-8) receptor, type A.
SPECIFICITY:
Recognizes human IL-8 receptor, type A.
APPLICATION:
Flow Cytometry (5µg/ml)
Immunohistochemistry (frozen sections)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products
•
Monoclonal Antibodies
•
CD Antibodies
ALX-804-593
Revised 31-Jul-07
Monoclonal Antibody to IL-8 Receptor, Type B (human) (X2.7)
SYNONYMS
anti-Interleukin-8 Receptor, Type B (human) MAb (X2.7)
anti-CXCR2 (human) MAb (X2.7)
anti-CXC Chemokine Receptor 2 (human) MAb (X2.7)
anti-CD182 (human) MAb (X2.7)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukin Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-593-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
X2.7
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
L1.2 cells expressing human IL-8 (interleukin-8) receptor, type B.
SPECIFICITY:
Recognizes human IL-8 receptor, type B.
APPLICATION:
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
CXC Chemokines & Receptors / Related Products
•
Monoclonal Antibodies
•
CD Antibodies
ALX-210-819
Revised 06-Nov-08
Polyclonal Antibody to CXCR4 (mouse)
SYNONYMS
anti-CXC Chemokine Receptor 4 (mouse) PAb
anti-CD184 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-819-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
1 mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 14-40 (Y
14
SEEVGSGDYDS
NKEPCFRDENVHFNR
40
) of the N-terminal extracellular domain of mouse CXCR4 (CXC chemokine receptor 4).
SPECIFICITY:
Recognizes mouse CXCR4.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections (1:200))
Western Blot (1:1’000)
QUALITY CONTROL:
Immunocytochemistry on mouse spleen cells.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-034
.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-820
Revised 25-Jan-07
Polyclonal Antibody to CXCR4 (human)
SYNONYMS
anti-CXC Chemokine Receptor 4 (human) PAb
anti-CD184 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CXC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-820-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 13-38 (CT
13
EEMGSGDYDSMKEPCFREENANFNK
38
) of the N-terminal extracellular domain of human CXCR4 (CXC chemokine receptor 4).
SPECIFICITY:
Recognizes human CXCR4.
APPLICATION:
Immunocytochemistry (acetone fixed cells (1:300))
Immunohistochemistry (paraffin sections (1:200))
Western Blot (1:1’000)
Functional Application (blocks SDF mediated stimulation of DU-145 cells)
QUALITY CONTROL:
Immunocytochemistry on human peripheral blood cells and immunohistochemistry on paraffin sections of human spleen cells.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-035
.
General Literature References
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes
:
M. Loetscher, et al.; J. Biol. Chem.
269
, 232 (1994)
Abstract
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
:
C.C. Bleul, et al.; Nature
382
, 829 (1996)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
© 2008 ALEXIS Corporation,
Privacy Policy
,
Disclaimer
,
Feedback
header picture ©
micronaut.ch
, another
CS2
website
