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ALX-162-017
Revised 08-Jan-03
N-Myristoyl-Lys-Arg-Thr-Leu-Arg-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-162-017-M001
1 mg
70.00 USD
ALX-162-017-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
42
H
82
N
12
O
8
MW:
883.2
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.
Product Specific Literature References
Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C:
C.G. Ioannides, et al.; Cell. Immunol.
131
, 242 (1990)
Abstract
N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor:
C.A. O'Brian, et al.; Biochem. Pharmacol.
39
, 49 (1990)
Abstract
Further Categories Containing This Product:
Peptides
•
Histones / Related Products
ALX-162-018
Revised 04-Jul-03
N-Myristoyl-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-OH
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-162-018-M001
1 mg
120.00 USD
ALX-162-018-M005
5 mg
480.00 USD
Product Specification
FORMULA:
C
60
H
105
N
17
O
12
MW:
1256.6
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective and cell permeable inhibitor of protein kinase C (PKC). The peptide corresponds to the pseudosubstrate domain of PKCα and PKCβ subtypes.
Product Specific Literature References
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor:
T. Eichholtz, et al.; J. Biol. Chem.
268
, 1982 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-163-011
Revised 14-Jul-08
NBD Peptide / NF-κB Blocker (cell permeable)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-163-011-1
1 Vial
240.00 USD
Product Specification
SEQUENCE:
GRKKRRQRRR-GG-TALDWSWLQTE-amide
FORMULA:
C
121
H
202
N
48
O
32
MW:
2841.2
QUANTITY:
50µl
CONCENTRATION:
10mM
PURITY:
≥95% (HPLC)
FORMULATION:
Liquid. In sterile PBS.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Protect from moisture. Keep on ice at all times.
POSITIVE CONTROL:
Prod. No.
ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Product Specific Literature References
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo:
E. Jimi, et al.; Nature Med.
10
, 617 (2004)
Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex:
M.J. May, et al.; Science
289
, 1550 (2000)
Abstract
Characterization of the Ikappa B-kinase NEMO binding domain:
M.J. May, et al.; J. Biol. Chem.
277
, 45992 (2002)
Abstract
Related Products
ALX-168-009/1
L-TAT Control Peptide (for Prod. No.
ALX-159-600
)
Further Categories Containing This Product:
Peptides
ALX-163-004
Revised 06-Jun-03
Neurogranin (28-43)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Substrates
Ordering Information
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ALX-163-004-M001
1 mg
120.00 USD
Product Specification
SEQUENCE:
H-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys-OH
FORMULA:
C
78
H
134
N
28
O
19
S
MW:
1800.2
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Peptide derived from the neurogranin phosphorylation domain. Highly selective substrate for protein kinase C (PKC), but very poor substrate for Ca
2+
/calmodulin-dependent kinase II and cAMP-dependent kinase (PKA).
Product Specific Literature References
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C:
S.-J. Chen, et al.; Biochemistry
32
, 1032 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-163-002
Revised 04-Jul-03
Neurotensin
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Neurotensin / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-163-002-P001
1 mg*
30.00 USD
ALX-163-002-P005
5 mg*
95.00 USD
Product Specification
SEQUENCE:
Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
FORMULA:
C
78
H
121
N
21
O
20
MW:
1673.0
CAS NUMBER:
58889-57-1
MERCK INDEX:
14:
6486
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
APPEARANCE:
Lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami:
R. Carraway & S.E. Leeman; J. Biol. Chem.
248
, 6854 (1973)
Abstract
;
Full Text
Neurotensin, a biologically active peptide:
G. Bissette, et al.; Life Sci.
23
, 2173 (1978)
Abstract
Further Categories Containing This Product:
Peptides
ALX-163-001
Revised 13-Feb-08
Nociceptin
SYNONYMS
Orphanin FQ
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
ORL1-Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-163-001-P001
1 mg*
70.00 USD
ALX-163-001-P005
5 mg*
280.00 USD
Product Specification
SEQUENCE:
H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
FORMULA:
C
79
H
129
N
27
O
22
MW:
1809.1
CAS NUMBER:
170713-75-4
QUANTITY:
*Sold as net peptide weight
PURITY:
≥97%
APPEARANCE:
Lyophilized.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
ORL
1
receptor agonist. The ORL
1
receptor structurally resembles opioid receptors and is negatively coupled with adenylyl cyclase.
Product Specific Literature References
Isolation and structure of the endogenous agonist of opioid receptor- like ORL1 receptor:
J.-C. Meunier, et al.; Nature
377
, 532 (1995)
Abstract
Orphanin FQ: a neuropeptide that activates an opioidlike G protein- coupled receptor:
R.K. Reinscheid, et al.; Science
270
, 792 (1995)
Abstract
N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin:
Y. Saito, et al.; BBRC
217
, 539 (1995)
Abstract
Primary structure and tissue distribution of the orphanin FQ precursor:
H.-P. Nothacker, et al.; PNAS
93
, 8677 (1996)
Abstract
Structure-activity relationship studies on the novel neuropeptide orphanin FQ:
R.K. Reinscheid, et al.; J. Biol. Chem.
271
, 14163 (1996)
Abstract
;
Full Text
Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide:
Y. Shimohigashi, et al.; J. Biol. Chem.
271
, 23642 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-163-003
Revised 06-Jun-03
NPY (human)
SYNONYMS
Neuropeptide Y (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-163-003-PC05
0.5 mg*
140.00 USD
ALX-163-003-P001
1 mg*
250.00 USD
Product Specification
SEQUENCE:
H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH
2
FORMULA:
C
189
H
285
N
55
O
57
S
MW:
4271.7
CAS NUMBER:
90880-35-6
MERCK INDEX:
14:
6485
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine:
C.D. Minth, et al.; PNAS
81
, 4577 (1984)
Abstract
Further Categories Containing This Product:
Leptin / Related Products
•
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-004
Revised 04-Jul-08
Obestatin (human)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Ghrelin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-164-004-M001
1 mg
130.00 USD
ALX-164-004-M005
5 mg
480.00 USD
Product Specification
SEQUENCE:
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH
2
FORMULA:
C
116
H
176
N
32
O
33
MW:
2546.9
PEPTIDE CONTENT:
≥80%
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake:
J.V. Zhang, et al.; Science
310
, 996 (2005)
Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals:
R. Nogueiras & M. Tschop; Science
310
, 985 (2005), (Comment)
Abstract
Further Categories Containing This Product:
Peptides
ALX-164-001
Revised 06-Jan-06
Orexin A (human, bovine, rat, mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-164-001-C100
100 µg
120.00 USD
ALX-164-001-C500
500 µg
370.00 USD
ALX-164-001-M001
1 mg
690.00 USD
Product Specification
SEQUENCE:
Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH
2
(Disulfide bonds between Cys
6
-Cys
12
and Cys
7
-Cys
14
).
FORMULA:
C
152
H
243
N
47
O
44
S
4
MW:
3561.2
PURITY:
≥98%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Hypothalamic neuropeptide that stimulates food intake in rats with impressive potency. Binds specifically to the OX
1
receptor.
Product Specific Literature References
Orexins and orexin receptors: a family of hypotalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-002
Revised 06-Jan-06
Orexin B (human)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-164-002-C100
100 µg
150.00 USD
Product Specification
SEQUENCE:
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH
2
FORMULA:
C
122
H
212
N
44
O
34
S
MW:
2871.4
PURITY:
≥95%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Like orexin A (Prod. No.
ALX-164-001
), orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX
1
receptor is significantly lower than that of orexin A. Binding affinities for the OX
2
receptor are similar for orexin A and B.
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-164-003
Revised 10-Jun-03
Orexin B (rat, mouse)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Orexins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-164-003-C100
100 µg
150.00 USD
Product Specification
SEQUENCE:
H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH
2
FORMULA:
C
125
H
215
N
45
O
33
S
MW:
2908.5
PURITY:
≥97%
FORMULATION:
Lyophilized.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior:
T. Sakurai, et al.; Cell
92
, 573 (1998)
Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger:
M.W. Schwartz; Nature Medicine
4
, 385 (1998)
Abstract
Further Categories Containing This Product:
Peptides
•
Neuropeptides & Receptors Other Products
ALX-165-003
Revised 17-Sep-07
PACAP (1-27) (human, sheep, rat)
