ALEXIS Biochemicals: Monoclonal Antibody to CD14 (biG 10)

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ALX-804-300

Revised 04-Mar-05

Monoclonal Antibody to TRAIL (human) (HS501)
SYNONYMS	anti-Apo-2L (human) MAb (HS501) anti-TNFSF 10 (human) MAb (HS501) anti-CD253 (human) MAb (HS501)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	TRAIL [Apo-2L]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-300-C100		100 µg	330.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	HS501
ISOTYPE:	Mouse IgG1
SOURCE/HOST:	Purified from concentrate hybridoma tissue culture supernatant.
CONCENTRATION:	0.25mg/ml
PURITY:	>95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing PEG-sucrose and 0.02% sodium azide.
IMMUNOGEN:	Recombinant human soluble TRAIL.
SPECIFICITY:	Recognizes human TRAIL.
APPLICATION:	Western Blot (excellent)
SHIPPING:	SHIPPED ON DRY ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-80°C
HANDLING:	Avoid freeze/thaw cycles. Thaw at +37°C.

Product Images

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Product Specific Literature References

TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-323

Revised 31-Jul-07

Monoclonal Antibody to Toll-like Receptor 2 (human) (TL2.1)
SYNONYMS	anti-TLR2 (human) MAb (TL2.1) anti-Toll/Interleukin-1 Receptor-like Gene 4 (human) MAb (TL2.1) anti-TIL4 (human) MAb (TL2.1) anti-CD282 (human) MAb (TL2.1)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-323-C050		50 µg	230.00 USD
ALX-804-323PF-C050	Preservative Free	50 µg	230.00 USD
ALX-804-323PF-C100	Preservative Free	100 µg	290.00 USD
ALX-804-323F-T100	FITC	100 tests	390.00 USD
ALX-804-323TD-T100	ATTO 488	100 tests	395.00 USD
ALX-804-323TS-T100	ATTO 647N	100 tests	395.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TL2.1
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	TL2.1: Liquid. In PBS containing 0.02% sodium azide. TL2.1PF: Liquid. In PBS. TL2.1-ATTO 488: Liquid. In PBS containing 0.02% sodium azide. TL2.1-ATTO 647N: Liquid. In PBS containing 0.02% sodium azide. TL2.1-FITC: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	CHO cells stably transfected with human TLR2 (Toll-like receptor 2).
SPECIFICITY:	Recognizes human TLR2. Does not cross-react with human TLR1 or TLR4.
APPLICATION:	TL2.1: ELISA Flow Cytometry [2, 4]: Incubate with 37°C (1:10-1:100) and then on ice with GAM-FITC. Immunohistochemistry Immunoprecipitation TL2.1 (Preservative Free): ELISA Flow Cytometry [2, 4]: Incubate with 37°C (1:10-1:100) and then on ice with GAM-FITC. Immunohistochemistry Immunoprecipitation Functional Application (blocking) [1, 5-7]: Use preservative free formulation. TL2.1-ATTO 488: Flow Cytometry (1:100) TL2.1-ATTO 647N: Flow Cytometry (1:100) TL2.1-FITC: Flow Cytometry [2, 4]
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.

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Product Description

New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
Licenced product covered by US Patent 7,071,310. Sold with permission of Leiv Eiriksson Nyskaping AS.

Product Specific Literature References

[1] Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products: E. Lien, et al.; J. Biol. Chem. 274, 33419 (1999) Abstract; Full Text
[2] Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide: T.H. Flo, et al.; J. Immunol. 164, 2064 (2000) Abstract; Full Text
[3] Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation: E. Faure, et al.; J. Immunol. 166, 2018 (2001) Abstract; Full Text
[4] Differential expression of Toll-like receptor 2 in human cells: T.H. Flo, et al.; J. Leukoc. Biol. 69, 474 (2001) Abstract
[5] A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway: E. Lien, et al.; J. Biol. Chem. 276, 1873 (2001) Abstract; Full Text
[6] Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2: S. Sugawara, et al.; Infect. Immun. 69, 4951 (2001) Abstract
[7] Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae: J.E. Wang, et al.; Infect. Immun. 69, 2402 (2001) Abstract; Full Text
[8] Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses: I. Sabroe, et al.; J. Immunol. 168, 4701 (2002) Abstract
[9] Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling: H.K. Lee, et al.; J. Immunol. 168, 4012 (2002) Abstract; Full Text
[10] A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization: D. van der Kleij, et al.; J. Biol. Chem. 277, 48122 (2002) Abstract; Full Text
[11] Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells: A.E. Medvedev, et al.; J. Immunol. 169, 5209 (2002) Abstract; Full Text
[12] Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction: E. Latz, et al.; J. Biol. Chem. 277, 47834 (2002) Abstract; Full Text
[13] Haemophilus influenzae porin induces Toll-like receptor 2-mediated cytokine production in human monocytes and mouse macrophages: M. Galdiero, et al.; Infect. Immun. 72, 1204 (2004) Abstract; Full Text
[14] Divergent trophoblast responses to bacterial products mediated by TLRs: V.M. Abrahams, et al.; J. Immunol. 173, 4286 (2004) Abstract
[15] The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies: N. Satta, et al.; Blood 109, 1507 (2007) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION	TL2.1-FITC: 1 test means: 1µl of a 0.1mg/ml stock solution were used to stain 200’000 cells in a sample volume of 50µl.
MANUFACTURER	Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-324

Revised 09-May-07

Monoclonal Antibody to Toll-like Receptor 2 (human) (TL2.3)
SYNONYMS	anti-TLR2 (human) MAb (TL2.3) anti-Toll/Interleukin-1 Receptor-like Gene 4 (human) MAb (TL2.3) anti-TIL4 (human) MAb (TL2.3) anti-CD282 (human) MAb (TL2.3)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-324-C050		50 µg	230.00 USD
ALX-804-324PF-C100	Preservative Free	100 µg	290.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TL2.3
ISOTYPE:	Mouse IgG2a
CONCENTRATION:	1mg/ml
FORMULATION:	TL2.3: Liquid. In PBS containing 0.02% sodium azide. TL2.3 (preservative free): Liquid. In PBS.
IMMUNOGEN:	CHO cells stably transfected with human TLR2 (Toll-like receptor 2).
SPECIFICITY:	Recognizes human TLR2. Does not cross-react with human TLR1 or TLR4.
APPLICATION:	ELISA Immunocytochemistry Immunohistochemistry (frozen sections)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

Product Description

Licenced product covered by US Patent 7,071,310. Sold with permission of Leiv Eiriksson Nyskaping AS.

Product Specific Literature References

Differential expression of Toll-like receptor 2 in human cells: T.H. Flo, et al.; J. Leukoc. Biol. 69, 474 (2001) Abstract
The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus: D. Iwaki, et al.; J. Biol. Chem. 277, 24315 (2002) Abstract; Full Text
Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target: K.W. Schjetne, et al.; J. Immunol. 171, 32 (2003) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-325

Revised 03-Nov-08

Monoclonal Antibody to TRAIL (human) (VI10E)
SYNONYMS	anti-Apo-2L (human) MAb (VI10E) anti-TNFSF 10 (human) MAb (VI10E) anti-CD253 (human) MAb (VI10E)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	TRAIL [Apo-2L]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-325-C100		100 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	VI10E
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE).
FORMULATION:	Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human soluble TRAIL.
SPECIFICITY:	Recognizes human TRAIL.
APPLICATION:	ELISA Flow Cytometry Immunoprecipitation
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Methods 259, 119 (2002) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-326

Revised 03-Nov-08

Monoclonal Antibody to TRAIL (human) (III6F)
SYNONYMS	anti-APO-2L (human) MAb (III6F) anti-TNFSF 10 (human) MAb (III6F) anti-CD253 (human) MAb (III6F)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	TRAIL [Apo-2L]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-326-C100		100 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	III6F
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE).
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human soluble TRAIL.
SPECIFICITY:	Recognizes human TRAIL.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen sections) Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Method. 259, 119 (2002) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-330

Revised 11-Nov-08

Monoclonal Antibody to EpCAM (human) (VU-1D9)
SYNONYMS	anti-Epithelial Specific Antigen (human) MAb (VU-1D9) anti-ESA (human) MAb (VU-1D9) anti-Epithelial Cell Adhesion Molecule (human) MAb (VU-1D9) anti-CD326 (human) MAb (VU-1D9)
PRODUCT LINE	Cytoskeleton
PRODUCT CATEGORY	Adhesion Molecules & Receptors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-330-C100		100 µg	259.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	VU-1D9
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS.
IMMUNOGEN:	Small cell lung carcinoma cells.
SPECIFICITY:	Recognizes human EpCAM (epithelial specific antigen), a 40 kDa epithelial protein expressed on baso-lateral cell surface in many epithelial tissues (but absent from mesothelial tissue). Differentiates between mesothelioma and carcinoma.
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections, paraffin sections (microwave treatment not necessary)) Immunoprecipitation Western Blot Functional Application (blocking) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Further Categories Containing This Product:

Monoclonal Antibodies • CD Antibodies

ALX-804-331

Revised 14-Mar-06

Monoclonal Antibody to CD40L (mouse) (MR1)
SYNONYMS	anti-CD154 (mouse) MAb (MR1) anti-gp39 (mouse) MAb (MR1) anti-TNFSF 5 (mouse) MAb (MR1)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	CD40 & CD40L [CD154] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-331-C100		100 µg	259.00 USD
ALX-804-331-C500		500 µg	490.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	MR1
ISOTYPE:	Hamster IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS.
IMMUNOGEN:	Recombinant mouse CD40L (CD154).
SPECIFICITY:	Recognizes mouse CD40L.
APPLICATION:	Functional Application (blocks T cell co-stimulation in vivo, promoting allograft acceptance and donor-specific tolerance to secondary skin grafts).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Specific Literature References

CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway: C.P. Larsen, et al.; Transplantation 61, 4 (1996) Abstract
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Monoclonal Antibodies • CD Antibodies

ALX-804-344

Revised 24-Jun-08

Monoclonal Antibody to TRAIL-R3 (human) (HS301)
SYNONYMS	anti-DcR1 (human) MAb (HS301) anti-TRID (human) MAb (HS301) anti-TNFRSF 10C (human) MAb (HS301) anti-CD263 (human) MAb (HS301)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	TRAIL-R3

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-344A-C100		100 µg	330.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	HS301
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:	Recombinant human TRAIL-R3 (DcR1).
SPECIFICITY:	Recognizes human TRAIL-R3. Does not cross-react with human TRAIL-R1, -R2 or -R4.
APPLICATION:	Flow Cytometry Immunocytochemisty For Western blot of whole cell lysate, use PAb to TRAIL-R3 (human) (from goat) (Prod. No. ALX-210-744).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Images

Please click on thumbnails to enlarge.

Product Specific Literature References

TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004) Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008) Abstract

ALX-211-200	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (FITC)
ALX-211-202	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (Biotin)
ALX-211-201	Polyclonal Antibody to Mouse IgG1 (Human & Mouse Ig adsorbed) (R-PE)
ALX-850-273	anti-TRAIL Receptor-1 to -4 Flow Cytometry Set