ALEXIS Biochemicals: SKF-525A . HCl

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ALX-106-010

Revised 14-Oct-08

NG-Monoethyl-L-arginine . monoacetate
SYNONYMS	L-NMEA . AcOH
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-010-M005		5 mg	30.00 USD
ALX-106-010-M025		25 mg	120.00 USD

Product Specification

FORMULA:	C₈H₁₈N₄O₂ . CH₃COOH
MW:	202.3 . 60.1
PURITY:	≥97%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

ALX-106-011

Revised 14-Oct-08

NG-Monomethyl-L-homoarginine . monoacetate
SYNONYMS	L-NMMHA . AcOH
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-011-M005		5 mg	30.00 USD
ALX-106-011-M025		25 mg	120.00 USD

Product Specification

FORMULA:	C₈H₁₈N₄O₂ . CH₃COOH
MW:	202.3 . 60.1
PURITY:	≥97%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

ALX-105-004

Revised 02-Dec-05

D-NAME . hydrochloride
SYNONYMS	N^G-Nitro-D-arginine-methyl ester . HCI
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-004-M250		250 mg	32.00 USD

Product Specification

FORMULA:	C₇H₁₅N₅O₄ . HCl
MW:	233.2 . 36.5
CAS NUMBER:	50912-92-0
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inactive isomer of L-NAME (Prod. No. ALX-105-003).

ALX-105-003

Revised 02-Dec-05

L-NAME . hydrochloride
SYNONYMS	N^G-Nitro-L-arginine-methyl ester . HCl
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-003-G005		5 g	32.00 USD
ALX-105-003-G025		25 g	133.00 USD

Product Specification

FORMULA:	C₇H₁₅N₅O₄ . HCl
MW:	233.2 . 36.5
CAS NUMBER:	51298-62-5
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of nitric oxide synthase (NOS). More soluble than N^G-Nitro-L-arginine (Prod. No. ALX-105-001). Suppresses the release of nitric oxide (NO) from endothelial cells. Has a different effect on the superoxide generation by NOS than L-NMMA (Prod. No. ALX-106-001).

Product Specific Literature References

L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Generation of superoxide by purified brain nitric oxide synthase: S. Pou, et al.; J. Biol. Chem. 267, 24173 (1992) Abstract; Full Text

ALX-270-010

Revised 07-Mar-05

L-NIL . dihydrochloride
SYNONYMS	L-N⁶-(1-Iminoethyl)-lysine . 2HCl
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-010-M010		10 mg	35.00 USD
ALX-270-010-M050		50 mg	140.00 USD

Product Specification

FORMULA:	C₈H₁₇N₃O₂ . 2HCl
MW:	187.2 . 73.0
CAS NUMBER:	159190-45-1
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Very hygroscopic.

Product Description

Selective inhibitor of inducible nitric oxide synthase (iNOS; NOS II).

Product Specific Literature References

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase: W.M. Moore, et al.; J. Med. Chem. 37, 3886 (1994) Abstract

ALX-270-470

Revised 16-Jul-07

L-NIL . acetate
SYNONYMS	L-N⁶-(1-Iminoethyl)-lysine . acetate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-470-M010		10 mg	25.00 USD
ALX-270-470-M050		50 mg	60.00 USD

Product Specification

FORMULA:	C₈H₁₇N₃O₂ . CH₃COOH
MW:	187.2 . 60.1
CAS NUMBER:	53774-63-3
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Very hygroscopic.

Product Description

Selective inhibitor of inducible nitric oxide synthase (iNOS; NOS II).

Product Specific Literature References

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase: W.M. Moore, et al.; J. Med. Chem. 37, 3886 (1994) Abstract

ALX-270-002

Revised 25-Oct-07

L-NIO . dihydrochloride
SYNONYMS	L-N⁵-(1-Iminoethyl)-ornithine . 2HCI
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-002-M025		25 mg	60.00 USD
ALX-270-002-M100		100 mg	180.00 USD

Product Specification

FORMULA:	C₇H₁₅N₃O₂ . 2HCl
MW:	173.2 . 73.0
CAS NUMBER:	36889-13-1
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Store desiccated under an inert atmosphere in the freezer at -20°C. Warm to room temperature before opening container. Repack under an inert atmosphere, preferably in a glove box.
HANDLING:	Hygroscopic.
HAZARD:	IRRITANT.

Product Description

Inhibitor of nitric oxide synthase (NOS).

Product Specific Literature References

Antimetabolites produced by microorganisms. VI. L-N 5 -(1-iminoethyl) ornithine: J.P. Scannell, et al.; J. Antibiot. (Tokyo) 25, 179 (1972) Abstract
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands: M. Palacios, et al.; BBRC 165, 802 (1989) Abstract
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo: D.D. Rees, et al.; Br. J. Pharmacol. 101, 746 (1990) Abstract
Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells: T.B. McCall, et al.; Br. J. Pharmacol. 102, 234 (1991) Abstract
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis: M.S. Mulligan, et al.; Br. J. Pharmacol. 107, 1159 (1992) Abstract

ALX-105-002

Revised 12-Nov-07

NG-Nitro-D-arginine
SYNONYMS	D-NOARG D-Nitroarginine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-002-M250		250 mg	22.00 USD
ALX-105-002-G001		1 g	53.00 USD

Product Specification

FORMULA:	C₆H₁₃N₅O₄
MW:	219.2
CAS NUMBER:	66036-77-9
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 0.1M HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

ALX-105-001

Revised 06-Jun-06

NG-Nitro-L-arginine
SYNONYMS	L-NOARG L-Nitroarginine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-001-G005		5 g	22.00 USD
ALX-105-001-G025		25 g	63.00 USD

Product Specification

FORMULA:	C₆H₁₃N₅O₄
MW:	219.2
CAS NUMBER:	2149-70-4
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 0.1N HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Inhibitor of nitric oxide synthase (NOS).

Product Specific Literature References

L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle: A. Gibson, et al.; Br. J. Pharmacol. 99, 602 (1990) Abstract
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation: K. Ishii, et al.; Eur. J. Pharmacol. 176, 219 (1990) Abstract
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation: N. Toda, et al.; Life. Sci. 47, 345 (1990) Abstract
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle: S.R. Brave, et al.; BBRC 179, 1017 (1991) Abstract
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo: M.A. Dwyer, et al.; BBRC 176, 1136 (1991) Abstract
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine: X. Chen and C.N. Gillis; BBRC 186, 1522 (1992) Abstract
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice: R.M. Quock and E. Nguyen; Life Sci. 51, PL255 (1992) Abstract
The role of nitric oxide in mediating non-adrenergic non-cholinergic relaxation in longitudinal muscle of human taenia coli: F.S.-F. Tam & K. Hillier; Life Sci 51, 1277 (1992) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Selective inhibition of constitutive nitric oxide synthase by L-NG- nitroarginine: E.S. Furfine, et al.; Biochemistry 32, 8512 (1993) Abstract
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor: Y.A. Kolesnikov, et al.; PNAS 90, 5162 (1993) Abstract
Reversible inactivation of endothelial nitric oxide synthase by NG- nitro-L-arginine: B. Mayer, et al.; FEBS Lett. 333, 203 (1993) Abstract

ALX-270-004

Revised 25-Feb-05

7-Nitroindazole
SYNONYMS	7-NI
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-004-M025		25 mg	25.00 USD
ALX-270-004-M100		100 mg	40.00 USD

Product Specification

FORMULA:	C₇H₅N₃O₂
MW:	163.1
CAS NUMBER:	2942-42-9
PURITY:	≥97%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in methanol (hot) or DMSO. Sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of nitric oxide synthase (NOS). See also 3-bromo-7-nitroindazole (Prod. No. ALX-270-009).

Product Specific Literature References

7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti- nociceptive activity in the mouse without increasing blood pressure: P.K. Moore, et al.; Br. J. Pharmacol. 108, 296 (1993) Abstract
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice: J.B. Schulz, et al.; J. Neurochem. 64, 936 (1995) Abstract

ALX-270-200

Revised 17-Oct-07

7-Nitroindazole . sodium salt
SYNONYMS	7-NiNa
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-200-M005		5 mg	25.00 USD
ALX-270-200-M025		25 mg	75.00 USD
ALX-270-200-M100		100 mg	225.00 USD

Product Specification

FORMULA:	C₇H₄N₃O₂ . Na
MW:	162.2 . 23.0
PURITY:	≥98%
APPEARANCE:	Orange to red solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.
HAZARD:	TOXIC. MAY BE TERATOGENIC. MAY BE MUTAGENIC.

Product Description

A more soluble salt form of 7-nitroindazole. Its higher solubility in artificial cerebrospinal fluid (CSF) permits its use as an inhibitor of nitric oxide synthase (NOS) in rat brain tissue. Provides a useful tool for the study of nitric oxide (NO) activity in the brain. See also 3-bromo-7-nitroindazole . sodium salt (Prod. No. ALX-270-199).

Product Specific Literature References