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ALX-155-011
Revised 04-Feb-05
ETA-Receptor Antagonist [BQ-610]
SYNONYMS
BQ-610
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-155-011-P001
1 mg*
125.00 USD
ALX-155-011-P005
5 mg*
500.00 USD
Product Specification
SEQUENCE:
(Hexahydro-1
H
-azepinyl)carbonyl-Leu-D-Trp(CHO)-D-Trp-OH
FORMULA:
C
36
H
44
N
6
O
6
MW:
656.8
QUANTITY:
*Sold as net peptide weight.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
30-fold more potent ET
A
antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane.
Further Categories Containing This Product:
Peptides
ALX-155-017
Revised 02-Dec-04
ETA-Receptor Antagonist [FR 139317]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-155-017-PC05
0.5 mg*
180.00 USD
ALX-155-017-P001
1 mg*
340.00 USD
Product Specification
SEQUENCE:
(Hexahydro-1
H
-azepinyl)carbonyl-Leu-D-Trp(Me)-D-Ala(2-pyridyl)-OH
FORMULA:
C
32
H
43
N
6
O
5
MW:
605.8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective ET
A
antagonist.
Product Specific Literature References
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists:
A.M. Doherty, et al.; J. Med. Chem.
36
, 2585 (1993)
Abstract
Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma:
B.-M. Löffler, et al.; FEBS Lett.
333
, 108 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-012
Revised 02-Dec-04
ETA-Receptor Antagonist [JKC-301]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-155-012-PC05
0.5 mg*
85.00 USD
ALX-155-012-P001
1 mg*
140.00 USD
Product Specification
SEQUENCE:
cyclo(D-Asp-Pro-D-Ile-Leu-D-Trp)
FORMULA:
C
32
H
44
N
6
O
7
MW:
624.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very potent ET
A
antagonist.
Product Specific Literature References
Lippton et al. ; American Heart Association, 66th Scientific Sessions, Georgia (World Congress, Nov. 8-11, 1993)
66
, 8 (1993)
The endothelin receptor profile in L6 myotubes:
Z. Fekete, et al.; Pharmacol. Exp. Ther.
275
, 215 (1995)
Abstract
Characterization of [125I]-endothelin-1 and [125I]-BQ3020 binding to rat cerebellar endothelin receptors:
P.S. Widdowson & C.N. Kirk; Br. J. Pharmacol.
118
, 2126 (1996)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-013
Revised 02-Dec-04
ETA-Receptor Antagonist [JKC-302]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-155-013-PC05
0.5 mg*
85.00 USD
ALX-155-013-P001
1 mg*
140.00 USD
Product Specification
SEQUENCE:
cyclo(D-Ser-Pro-D-Val-Leu-D-Trp)
FORMULA:
C
30
H
42
N
6
O
6
MW:
582.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very potent ET
A
antagonist.
Product Specific Literature References
Lippton et al.; American Heart Association, 66th Scientific Sessions, Georgia (World Congress, Nov. 8-11, 1993)
66
, 8 (1993)
Further Categories Containing This Product:
Peptides
ALX-155-020
Revised 17-Mar-08
ETB-Receptor Antagonist . sodium salt
SYNONYMS
BQ-788 . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-155-020-MC05
0.5 mg
133.00 USD
ALX-155-020-M001
1 mg
185.00 USD
Product Specification
SEQUENCE:
N-
cis
-2,6-Dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa
FORMULA:
C
34
H
50
N
5
O
7
Na
MW:
663.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol (0.5mg/ml), DMSO (4mg/ml), 0.1M sodium bicarbonate (3mg/ml) or 100% ethanol (4mg/ml); insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly potent and selective ET
B
-receptor antagonist.
Product Specific Literature References
Clearance of circulating endothelin-1 by ETB receptors in rats:
T. Fukuroda, et al.; BBRC
199
, 1461 (1994)
Abstract
Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788:
K. Ishikawa, et al.; PNAS
91
, 4892 (1994)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-010
Revised 05-Dec-04
ETB-Receptor Agonist [4 Ala ET-1]
SYNONYMS
[Ala
1,3,11,15
]-Endothelin-1
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-155-010-PC05
0.5 mg*
210.00 USD
ALX-155-010-P001
1 mg*
380.00 USD
Product Specification
SEQUENCE:
H-Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
FORMULA:
C
109
H
163
N
25
O
32
MW:
2335.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly selective ligand for the ET
B
receptor.
Product Specific Literature References
[Ala1,3,11,15]endothelin-1 analogs with ETB agonistic activity:
T. Saeki, et al.; BBRC
179
, 286 (1991)
Abstract
Identification of high affinity endothelin-1 receptor subtypes in human tissues:
D.L. Williams Jrs., et al.; BBRC
180
, 475 (1991)
Abstract
Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1:
K. Nakamichi, et al.; BBRC
182
, 144 (1992)
Abstract
Solid-phase synthesis of [Ala1,3,11,15]-endothelin-1 by a modified double-coupling procedure:
J. Green; Int. J. Pept. Prot. Res.
41
, 492 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-015
Revised 02-Dec-04
ETB-Receptor Agonist [BQ-3020]
SYNONYMS
N-Acetyl-[Ala
11,15
]-Endothelin-1 (6-21)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-155-015-PC05
0.5 mg*
90.00 USD
ALX-155-015-P001
1 mg*
160.00 USD
Product Specification
SEQUENCE:
Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
FORMULA:
C
96
H
140
N
20
O
25
S
MW:
2006.3
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective ligand for the ET
B
receptor.
Product Specific Literature References
A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors
:
M. Ihara, et al.; Life Sci.
51
, PL47 (1992)
Abstract
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB- selective agonists:
A. Sakamoto, et al.; J. Biol. Chem.
268
, 8547 (1993)
Abstract
;
Full Text
Identification of a ligand-binding site of the human endothelin-A receptor and specific regions required for ligand selectivity:
M. Adachi, et al.; Eur. J. Biochem.
220
, 37 (1994)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-006
Revised 24-Feb-05
ETB-Receptor Agonist [IRL-1620]
SYNONYMS
Suc-[Glu
9
, Ala
11,15
]-Endothelin-1 (8-21)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-155-006-PC05
0.5 mg*
100.00 USD
ALX-155-006-P001
1 mg*
175.00 USD
Product Specification
SEQUENCE:
Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
FORMULA:
C
86
H
117
N
17
O
27
MW:
1821.0
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Most potent and selective ligand for the ET
B
receptor. IRL-1620 together with IRL-1038 (Prod. No.
ALX-155-007
) is an indispensable pharmacological tool to assess the participation of the ET
B
receptor in some pathophysiological phenomena, by selectively stimulating ET
B
receptor-mediated responses in various pathophysiological models established
in vitro
and
in vivo
.
Product Specific Literature References
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor:
M. Takai, et al.; BBRC
184
, 953 (1992)
Abstract
Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB- selective agonists:
A. Sakamoto, et al.; J. Biol. Chem.
268
, 8547 (1993)
Abstract
;
Full Text
Endothelin: progress in pharmacology and physiology:
W.G. Haynes, et al.; TIPS
14
, 225 (1993), (Review)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-007
Revised 24-Feb-05
ETB-Receptor Antagonist [IRL-1038]
SYNONYMS
[Cys
11
-Cys
15
]-Endothelin-1 (11-21)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-007-PC05
0.5 mg*
110.00 USD
ALX-155-007-P001
1 mg*
190.00 USD
Product Specification
SEQUENCE:
H-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys
1
-Cys
5
)
FORMULA:
C
68
H
92
N
14
O
15
S
2
MW:
1409.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist for the ET
B
receptor with a controversial pattern of activity.
Product Specific Literature References
A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor:
M. Takai, et al.; BBRC
184
, 953 (1992)
Abstract
An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]- endothelin-1(11-21) [retracted in: FEBS Lett 1994 Mar 28;342(1):103]:
Y. Urade, et al.; FEBS Lett.
311
, 12 (1992)
Abstract
Endothelin: progress in pharmacology and physiology:
W.G. Haynes, et al.; TIPS
14
, 225 (1993), (Review)
Abstract
An endothelin B receptor-selective antagonist: IRL 1038, [Cys11- Cys15]- endothelin-1(11-21):
Y. Urade, et al.; FEBS Lett.
342
, 103 (1994)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-018
Revised 23-Oct-07
ETB-Receptor Antagonist [RES-701-1]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-155-018-MC05
0.5 mg
130.00 USD
ALX-155-018-M001
1 mg
200.00 USD
Product Specification
SEQUENCE:
Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH
(Beta peptide bond between Gly
1
and Asp
9
).
FORMULA:
C
103
H
115
N
23
O
23
MW:
2043.2
PEPTIDE CONTENT:
75-90%
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO (5mg/ml); dilute with 0.6ml distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibits selectively the ET-1 binding to the ET
B
receptor.
Product Specific Literature References
RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. I. Characterization of producing strain, fermentation, isolation, physico-chemical and biological properties:
Y. Morishita, et al.; J. Antibiot.
47
, 269 (1994)
Abstract
Subtypes of endothelin ETA and ETB receptors mediating venous smooth muscle contraction:
S.A. Sudjarwo, et al.; BBRC
200
, 627 (1994)
Abstract
J.X. He, et al.; Bioorg. Med. Chem. Lett.
5
, 621 (1995)
Further Categories Containing This Product:
Peptides
ALX-155-019
Revised 02-Dec-04
ETB-Receptor Antagonist [RES-701-3]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-019-MC05
0.5 mg
130.00 USD
ALX-155-019-M001
1 mg
240.00 USD
Product Specification
SEQUENCE:
Gly-Asn-Trp-His-Gly-Thr-Ser-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH
(Beta peptide bond between Gly
1
and Asp
9
).
FORMULA:
C
103
H
115
N
23
O
24
MW:
2059.2
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Peptides
ALX-350-098
Revised 05-Apr-08
Ferutinin (high purity)
