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ALX-210-143/1
Revised 23-Jun-08
Polyclonal Antibody to Ca2+-Sensing Receptor
SYNONYMS
anti-CASR PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
G-Protein Coupled Receptors & Ligands Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-143/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1.4mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 12-27 (A
12
LAWHSSAYGPDQRAQ
27
) of rat CASR (Ca
2+
-sensing receptor).
SPECIFICITY:
Recognizes human and rat CASR. Detects a band of ~120kDa by Western blot.
APPLICATION:
Western Blot (1:100)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-167-010
.
Product Specific Literature References
Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium
:
S.E. McNeil, et al.; J. Biol. Chem.
273
, 1114 (1998)
Abstract
;
Full Text
General Information
The calcium sensing receptor (CASR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CASR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CASR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-804
Revised 09-Oct-08
Polyclonal Antibody to Caspase-1
SYNONYMS
anti-Interleukin-1β Converting Enzyme PAb
anti-IL-1β Converting Enzyme PAb
anti-ICE PAb
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-804-C100
100 µg
315.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml.
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
IMMUNOGEN:
Synthetic peptide corresponding to aa 129-152 of human caspase-1.
SPECIFICITY:
Recognizes human, mouse and rat caspase-1. Detects bands of ~45kDa (procaspase-1) and ~20kDa (cleavage product) by Western blot.
APPLICATION:
Immunocytochemistry (10-20µg/ml)
Immunoprecipitation (4-8µg/ml)
Western Blot (0.5-4µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Inflammasome
•
Polyclonal Antibodies
ALX-210-806
Revised 20-Mar-06
Polyclonal Antibody to Caspase-3
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-806-C100
100 µg
273.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 1% BSA, 0.02% thimerosal and 50% glycerol.
IMMUNOGEN:
Synthetic peptide corresponding to aa 163-175 of human caspase-3.
SPECIFICITY:
Recognizes human, mouse and rat caspase-3. Detects bands of ~32kDa (procaspase-3) and ~20kDa (cleavage product) by Western blot.
APPLICATION:
Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Apoptosis & Necrosis Detection Other Products
•
Polyclonal Antibodies
ALX-210-807
Revised 22-Oct-07
Polyclonal Antibody to Caspase-3 (active)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-807-C100
100 µg
371.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml.
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 50% glycerol, 1% BSA and 0.02% thimerosal.
IMMUNOGEN:
Synthetic peptide around the cleavage site of human caspase-3.
SPECIFICITY:
Recognizes human, mouse and rat active caspase-3 (p20 subunit). Does not cross-react with procaspase-3 (~32kDa).
APPLICATION:
Immunohistochemistry (paraffin sections (10-20µg/ml))
Western Blot (0.5-4µg/ml)
Optimal conditons must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-062
.
Related Products
ALX-153-062
Blocking Peptide for PAb to Caspase-3 (active) (Prod. No.
ALX-210-807
)
Further Categories Containing This Product:
Apoptosis & Necrosis Detection Other Products
•
Polyclonal Antibodies
ALX-210-808
Revised 05-Mar-07
Polyclonal Antibody to Caspase-4
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-808-C100
100 µg
357.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 0.5% BSA, 0.01% thimerosal and 30% glycerol.
IMMUNOGEN:
Synthetic peptide corresponding to aa 85-101 of human caspase-4.
SPECIFICITY:
Recognizes human, mouse and rat procaspase-4. Detects a band of ~43kDa by Western blot.
APPLICATION:
Western Blot (1-2µg/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Polyclonal Antibodies
ALX-210-809
Revised 19-May-08
Polyclonal Antibody to Caspase-5
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-809-C100
100 µg
273.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
IMMUNOGEN:
Synthetic peptide surrounding aa 162 of human caspase-5.
SPECIFICITY:
Recognizes human, mouse, rat, hamster, monkey, rabbit and bovine caspase-5. Preferentially detects the intermediate (32kDa) and the fully cleaved (20kDa) caspase-5 by Western blot.
APPLICATION:
Western Blot (0.5-4µg/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Inflammasome
•
Polyclonal Antibodies
ALX-210-810
Revised 20-Dec-04
Polyclonal Antibody to Caspase-6
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-810-C100
100 µg
357.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Affinity purified antibody in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 250-264 of human caspase-6.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, dog, pig, monkey, hamster, rabbit and bovine caspase-6. Detects bands of ~34kDa (caspase-6) and ~22kDa (alternatively spliced β-isoform) by Western blot.
APPLICATION:
Western Blot (2-4µg/ml)
Optimal conditions must be determined indiviually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-012
Revised 29-Jun-05
Polyclonal Antibody to Caspase-6 (human)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-012-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human caspase-6 (catalytic subunit).
SPECIFICITY:
Recognizes human caspase-6. Detects both procaspase-6 and active caspase-6.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3
:
T. Miyashita, et al.; Cell Death Differ.
5
, 1034 (1998)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-811
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-811-C100
100 µg
357.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
Pig
Monkey
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Affinity purified antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 264-279 of human caspase-7.
SPECIFICITY:
Recognizes human, mouse, rat, hamster, monkey, rabbit, dog, pig and sheep caspase-7. Detects bands of ~34kDa (full length caspase-7) and ~10kDa (p10 subunit of the active form of caspase-7) by Western blot.
APPLICATION:
Western Blot (1-2µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-812
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-812-C100
100 µg
273.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 159-170 of human caspase-7.
SPECIFICITY:
Recognizes human, mouse and rat caspase-7. Detects bands of ~34kDa (full length caspase-7) and ~20kDa (processed caspase-7) by Western blot.
APPLICATION:
Western Blot (1-4µg/ml)
Optimal conditions must be determined individually.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-813
Revised 29-Nov-04
Polyclonal Antibody to Caspase-7 (active)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-813-C100
100 µg
371.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.2mg/ml
FORMULATION:
Liquid. Affinity purified antibody in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide around the cleavage site of human caspase-7.
SPECIFICITY:
Recognizes human, mouse and rat active caspase-7 p20 subunit. Does not cross-react with procaspase-7 or other caspases.
APPLICATION:
Immunocytochemistry (5µg/ml)
Immunohistochemistry (10-20µg/ml)
Immunoprecipitation (10-20µg/ml)
Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-013
Revised 29-Jun-05
Polyclonal Antibody to Caspase-7 (human)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-013-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human caspase-7 (large catalytic subunit).
SPECIFICITY:
Recognizes human caspase-7. Detects both procaspase-7 and the large subunit of active caspase-7.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile
:
P.W. Mesner Jr., et al.; J. Biol. Chem.
274
, 22635 (1999)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
