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Polyclonal Antibodies
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ALX-210-001 Revised 29-Jun-05
Polyclonal Antibody to A1 (mouse)
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SYNONYMS anti-Bfl-1 (mouse) PAb
anti-Bcl-2-related Protein A1 (mouse) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-001-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 34-51 (C34RVLQRVAFSVQKEVEKN51) of mouse Bcl-2-related protein A1.
SPECIFICITY: Recognizes mouse A1.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation: E.Y. Lin, et al.; Blood 87, 983 (1996) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-002 Revised 29-Jun-05
Polyclonal Antibody to Bak
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SYNONYMS anti-BCL2L7 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Members Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-002-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 14-36 (C14GEPALPSASEEQVAQDTEEVFR36) of human Bak.
SPECIFICITY: Recognizes human, mouse and rat Bak. Detects a band of ~24kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot (1-2µl/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
Product Specific Literature References
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas: M. Krajewska, et al.; Cancer Res. 56, 2422 (1996) Abstract
Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family: S. Krajewski, et al.; Cancer Res. 56, 2849 (1996) Abstract
Increased intestinal Bak expression results in apoptosis: S.F. Moss, et al.; BBRC 223, 199 (1996) Abstract
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth: S. Krajewski, et al.; Cell Death Differ. 5, 408 (1998) Abstract
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1: I.M. Pedersen, et al.; Blood 100, 1795 (2002) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-003 Revised 29-Jun-05
Polyclonal Antibody to Bax
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SYNONYMS anti-BCL2L4 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bax / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-003-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 43-61 (P43ELTLEQPPQDASTKKLSE61) of mouse Bax. This sequence is completely conserved in rat Bax.
SPECIFICITY: Recognizes human, mouse and rat Bax.
APPLICATION: Immunohistochemistry (frozen sections, paraffin sections (1:500-1:2'000))
Immunoprecipitation (1µl/106 cells)
Western Blot (1:500-1:2'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
Product Specific Literature References
Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2: S. Krajewski, et al.; Am. J. Pathol. 145, 1323 (1994) Abstract
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal: H.E. Broome, et al.; J. Immunol. 155, 2311 (1995) Abstract
Upregulation of bax protein levels in neurons following cerebral ischemia: S. Krajewski, et al.; J. Neurosci. 15, 6364 (1995) Abstract
Overexpression of the Bcl-2 protein increases the half-life of p21Bax: T. Miyashita, et al.; J. Biol. Chem. 270, 26049 (1995) Abstract; Full Text
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis: R.C. Humphreys, et al.; Development 122, 4013 (1996) Abstract; Full Text
Developmental expression patterns of Bcl-2, Bcl-x, Bax, and Bak in teeth: S. Krajewski, et al.; Cell Death Differ. 5, 408 (1998) Abstract
Bax cleavage is mediated by calpain during drug-induced apoptosis: D.E. Wood, et al.; Oncogene 17, 1069 (1998) Abstract
Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis: J.E. Kim, et al.; J. Neurochem. 72, 2456 (1999) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-004 Revised 29-Jun-05
Polyclonal Antibody to Bcl-XL/S (1695)
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SYNONYMS anti-BCL2L1 PAb (1695)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-004-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 46-66 (E46TPSAINGNPSWHLADSPAVN66) of human Bcl-X. This sequence is completely conserved in mouse, rat and pig Bcl-X.
SPECIFICITY: Recognizes human and mouse Bcl-XL and Bcl-XS.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Immunohistochemical analysis of in vivo patterns of Bcl-X expression: S. Krajewski, et al.; Cancer Res. 54, 5501 (1994) Abstract
High expression of the bcl-x gene in Reed-Sternberg cells of Hodgkin's disease: D. Schlaifer, et al.; Blood 85, 2671 (1995) Abstract; Full Text
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse: S.H. Kaufmann, et al.; Blood 91, 991 (1998) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-005 Revised 21-Aug-07
Polyclonal Antibody to Bcl-XL/S (1688)
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SYNONYMS anti-BCL2L1 PAb (1688)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-005-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 61-79 (D61SPAVNGATGHSSSLDARE79) of human Bcl-X. This sequence is completely conserved in mouse, rat and pig Bcl-X.
SPECIFICITY: Recognizes human and mouse Bcl-XL and Bcl-XS.
APPLICATION: Immunohistochemistry (paraffin sections)
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Immunohistochemical analysis of in vivo patterns of Bcl-X expression: S. Krajewski, et al.; Cancer Res. 54, 5501 (1994) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-006 Revised 27-Oct-05
Polyclonal Antibody to Bid (human) (AR-54)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
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ALX-210-006-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 28-50 (C28SDNSFRRELDALG
HELPVLAPQ50) of human Bid.
SPECIFICITY: Recognizes human, mouse and rabbit Bid. Detects a band of ~22kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections (1:3’000))
Western Blot (1:1’000-1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion: M. Chen, et al.; J. Biol. Chem. 276, 30724 (2001) Abstract; Full Text
Expression of Bcl-2 family member Bid in normal and malignant tissues: M. Krajewska, et al.; Neoplasia 4, 129 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-007 Revised 27-Oct-05
Polyclonal Antibody to Bid (mouse) (AR-52)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-007-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant full length mouse Bid.
SPECIFICITY: Recognizes human, mouse and rat Bid. Detects a band of ~22kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections (1:4'000-1:8'000))
Western Blot (1:1'000-1:5'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous system: M. Krajewska, et al.; Cell Death Differ. 9, 145 (2002) Abstract
Expression of Bcl-2 family member Bid in normal and malignant tissues: M. Krajewska, et al.; Neoplasia 4, 129 (2002) Abstract
Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury: G. Franz, et al.; J. Cereb. Blood Flow. Metab. 22, 951 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-008 Revised 30-Nov-06
Polyclonal Antibody to Mcl-1 (human)
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SYNONYMS anti-Myeloid Cell Leukemia-1 (human) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Mcl-1 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-008-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 121-139 (S121PEEELDGYEPEPLGKRPA139) of human Mcl-1 (myeloid cell leukemia-1). This sequence is completely conserved in cat and dog Mcl-1.
SPECIFICITY: Recognizes human Mcl-1. Detects a band of ~39-43kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections, paraffin sections (1:800-1:1’000))
Immunoprecipitation (1µl/1x106 cells)
Western Blot (1:800-1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
USE/STABILITY:

Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes: S. Krajewski, et al.; Am. J. Pathol. 145, 515 (1994) Abstract
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas: M. Krajewska, et al.; Cancer Res. 56, 2422 (1996) Abstract
Increased intestinal Bak expression results in apoptosis: S.F. Moss, et al.; BBRC 223, 199 (1996) Abstract
Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin: S. Krajewski, et al.; Am. J. Pathol. 150, 805 (1997) Abstract
Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse: S.H. Kaufmann, et al.; Blood 91, 991 (1998) Abstract; Full Text
Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses: S. Kitada, et al.; Blood 91, 3379 (1998) Abstract; Full Text
Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia: S. Kitada, et al.; Br. J. Haematol. 106, 995 (1999) Abstract
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia: S. Kitada, et al.; Blood 96, 393 (2000) Abstract; Full Text
Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer: M. Guzey, et al.; Mol. Cancer Ther. 1, 667 (2002) Abstract; Full Text
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1: I.M. Pedersen, et al.; Blood 100, 1795 (2002) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-009 Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (mouse) (CT) (Bur 1702)
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SYNONYMS anti-Bcl-2 Associated Athanogene-1 (mouse) (CT) PAb (Bur 1702)
anti-BAG Family Molecular Chaperone Regulator 1 (mouse) (CT) (Bur 1702) PAb
anti-RAP46 (mouse) (CT) (Bur 1702) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-009-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 204-219 (C204QETERLQSTNLALAE219) of mouse BAG-1 (Bcl-2 associated athanogene-1).
SPECIFICITY: Recognizes mouse BAG-1.
APPLICATION: Immunohistochemistry (paraffin sections (1:2'500))
Immunoprecipitation (transfected cells)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity: S. Takayama, et al.; Cell 80, 279 (1995) Abstract
Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain: M. Adachi, et al.; Blood 88, 4118 (1996) Abstract; Full Text
Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1: H.G. Wang, et al.; PNAS 93, 7063 (1996) Abstract; Full Text
Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2: C.V. Clevenger, et al.; Mol. Endocrinol. 11, 608 (1997) Abstract; Full Text
Bag1 is a regulator and marker of neuronal differentiation: P. Kermer, et al.; Cell Death Differ. 9, 405 (2002) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-1 functions as a nucleotide exchange factor of mammalian cytosolic HSC70, thereby triggering substrate unloading from the chaperone. In addition BAG-1 associates with the proteasome, playing a role in coordinating chaperone and degradation pathways. Aberrant BAG-1 expression has been observed in certain human cancers.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions: S. Alberti, et al.; Cell Stress Chaperones 8, 225 (2003) Abstract; Full Text
BAG-1: a multi-functional pro-survival molecule: P.A. Townsend, et al.; Int. J. Biochem. Cell. Biol. 37, 251 (2005) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Chaperone-mediated Autophagy [CMA] • Polyclonal Antibodies • Ubiquitin Ligases [E3]
 
 
ALX-210-010 Revised 22-Apr-08
Polyclonal Antibody to BAG-1 (NT) (Bur 1735)
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SYNONYMS anti-Bcl-2 Associated Athanogene-1 (NT) PAb (Bur 1735)
anti-BAG-family Molecular Chaperone Regulator 1 (NT) (Bur 1735) PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-010-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: