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Obesity & Adipokines
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ALX-270-235 Revised 04-Feb-05
JM 42
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SYNONYMS N-(4,6-Dimethylpyridin-2-yl)-5-bromofurane-2-carboxamide
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TNF-alpha & TNF Receptors Other Products
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ALX-270-235-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C12H11BrN2O2
MW: 295.1
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: For biological studies, solubilize as a maleate salt just before use.
HANDLING: Keep under inert gas. Protect from light.

Product Description
Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α involved pathogenesis.
Product Specific Literature References
New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation: F. Lang, et al.; J. Pharmacol. Exp. Ther. 275, 171 (1995) Abstract
 
 
ALX-385-005 Revised 21-May-08
Kaempferol
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SYNONYMS 3,4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-005-M010   10 mg 40.00 USD Add To Cart
ALX-385-005-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 520-18-3
MERCK INDEX: 14: 5274
RTECS: LK9275200
PURITY: ≥90%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in ether or 100% ethanol (hot); slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Product Description
Antioxidant flavonoid. Apoptosis inducer. Reversible inhibitor of fatty acid synthase (FAS).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li & W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Fatty Acid Synthase [FAS] / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants
 
 
ALX-350-223 Revised 07-Apr-08
Kahweol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-223-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H26O3
MW: 314.2
CAS NUMBER: 6894-43-5
SOURCE/HOST: Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Specific Literature References
R.O. Bengis & R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982) Abstract
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem. 30, 1399 (1987) Abstract
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis 17, 2377 (1996) Abstract
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res. 376, 115 (1997) Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol. 217, 332 (2006) Abstract
Further Categories Containing This Product:
Glutathione S-Transferase • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Enzyme Activators & Inducers) • TNF-alpha & TNF Receptors Other Products • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-201-433 Revised 06-Aug-08 New product
Klotho (Extracellular Domain) (human):Fc (human) (recombinant)
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SYNONYMS KL (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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ALX-201-433-C010   10 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UEF7: Klotho (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Insulin & Insulin Receptor / Related Products
 
 
ALX-201-434 Revised 06-Aug-08 New product
βKlotho (Extracellular Domain) (human):Fc (human) (recombinant)
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SYNONYMS BKL (Extracellular Domain) (human):Fc (human) (recombinant)
Klotho beta-like Protein(Extracellular Domain) (human):Fc (human) (recombinant)
KLB (Extracellular Domain) (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Fibroblast Growth Factors [FGFs] & Receptors / Related Products
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ALX-201-434-C010   10 µg 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q86Z14: βKlotho (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
BetaKlotho is required for metabolic activity of fibroblast growth factor 21: Y. Ogawa, et al.; PNAS 104, 7432 (2007) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Insulin & Insulin Receptor / Related Products
 
 
ALX-430-023 Revised 11-Mar-05
KN-93
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SYNONYMS 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-430-023-M001   1 mg 84.00 USD Add To Cart
ALX-430-023-M005   5 mg 336.00 USD Add To Cart
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Product Specification
FORMULA: C26H29ClN2O4S
MW: 501.0
CAS NUMBER: 139298-40-1
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 5 years after receipt when stored at +4°C. DMSO stock solutions are stable for 3-4 months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Induces G1 cell cycle arrest and apoptosis.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN- 93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differentiation 6, 1063 (1995) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-430-127 Revised 20-Feb-07
KN-93 (water soluble)
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SYNONYMS KN-93 . hydrogen phosphate
2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-430-127-M001   1 mg 90.00 USD Add To Cart
ALX-430-127-M005   5 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C26H29ClN2O4S . H3PO4
MW: 501.0 . 98.0
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Hygroscopic.
HAZARD: IRRITANT.

Product Description
Selective inhibitor of rat brain Ca2+/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
Product Specific Literature References
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991) Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993) Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993) Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-201-034 Revised 02-May-06
Leptin (human) (recombinant)
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SYNONYMS OB Gene Product (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-034-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to human serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from sterile filtered solution in 10mM sodium citrate, pH 4.0.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing 0.1% HSA or BSA.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and freeze in liquid nitrogen.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P41159: Leptin (human) (precursor)
General Literature References
Leptin and the regulation of body weight in mammals: J.M. Friedman and J.L. Halaas; Nature 395, 763 (1998), review Abstract
Mutation screening and identification of a sequence variation in the human ob gene coding region: R.V. Considine, et al.; BBRC 220, 735 (1996) Abstract
Serum immunoreactive leptin concentrations in normal-weight and obese humans  : R.V. Considine, et al. ; New Engl. J. Med. 334, 292 (1996) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects  : M. Maffei, et al.; Nature Medicine 1, 1155 (1995) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice  : M.A. Pelleymounter, et al. ; Science 269, 540 (1995) Abstract
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity  : R.V. Considine, et al. ; J. Clin. Invest 95, 2986 (1995) Abstract
Overexpression of the obese (ob) gene in adipose tissue of the human subjects  : F. Lönnqvist, et al. ; Nature Medicine 1, 950 (1995) Abstract
Positional cloning of the mouse obese gene and its human homologue  : Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-035 Revised 18-May-06
Leptin (mouse) (recombinant)
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SYNONYMS OB Gene Product (mouse) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-035-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to mouse serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein.
RECONSTITUTION: Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY: Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. Studies have shown that it may also influence reproductive function. Mice with ob/ob genotype develop a form of diabetes similar to type II in humans.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link 41160: Leptin (mouse) (precursor)
AfCS Signalling Gateway link A001397: Leptin (mouse)
General Literature References
Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects: M. Maffei, et al.; Nature Med. 1, 1155 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-231 Revised 18-Mar-08
Leptin (rat) (recombinant)
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