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Items 11 of 11
ALX-850-323
Revised 31-Jul-08
ADMA Direct (human) ELISA Kit
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide & NOS Detection / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-850-323-KI01
1 Kit
1'100.00 USD
Product Specification
SENSITIVITY:
0.05μmol/l (expected value: 0.45µmol/l ± 0.19µmol/l)
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the quantitative detection of asymmetrical dimethylarginine (ADMA) in human EDTA-plasma and serum. Does not cross-react with SDMA, NMMA or L-arginine.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Store standard and controls at -20°C. Store rest of the kit at +4°C.
General Information
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a novel cardiovascular risk factor.
MANUFACTURER
Manufactured by Immundiagnostik AG.
Related Products
ALX-850-327
ADMA Direct (mouse/rat) ELISA Kit
Further Categories Containing This Product:
ELISA & EIA Kits
•
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-850-327
Revised 31-Jul-08
ADMA Direct (mouse/rat) ELISA Kit
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitric Oxide & NOS Detection / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-327-KI01
1 Kit
1'400.00 USD
Product Specification
SENSITIVITY:
0.05μmol/l
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the quantitative detection of asymmetrical dimethylarginine (ADMA) in mouse or rat EDTA-plasma and serum. Does not cross-react with SDMA, NMMA or L-arginine.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Store standard and controls at -20°C. Store rest of the kit at +4°C.
General Information
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis. NO is one of the major endothelium-derived vasoactive mediators and is involved in the modulation of blood flow and blood pressure. Even small changes of ADMA concentration alter vascular NO production, vascular tone, and systemic vascular resistence. Elevated ADMA concentrations are found in patients with diabetes mellitus, hypercholeste-rolemia, hypertension, pulmonary hypertension, peripheral arterial disease, chronic renal failure, preeclampsia or erectile dysfunction. ADMA is therefore a novel cardiovascular risk factor.
MANUFACTURER
Manufactured by Immundiagnostik AG.
Related Products
ALX-850-323
ADMA Direct (human) ELISA Kit
Further Categories Containing This Product:
ELISA & EIA Kits
•
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-270-440
Revised 13-Nov-08
AMI-1
SYNONYMS
Arginine N-Methyltransferase Inhibitor-1
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
PRMTs, Mono- & Dimethylarginine / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-440-M005
5 mg
90.00 USD
ALX-270-440-M025
25 mg
360.00 USD
Product Specification
FORMULA:
C
21
H
12
N
2
O
9
S
2
Na
4
MW:
592.4
PURITY:
≥98% (
1
H-NMR and HPLC)
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in water, 100% ethanol or DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Protect from light. Hygroscopic.
Product Description
Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC
50
=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC
50
=5.0µM).
Product Specific Literature References
A novel mechanism for inhibition of HIV-1 reverse transcriptase:
A.G. Skillman, et al.; Bioorg. Chem.
30
, 443 (2002)
Abstract
Small molecule regulators of protein arginine methyltransferases:
D. Cheng, et al.; J. Biol. Chem.
279
, 23892 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
HIV / AIDS / Related Products
ALX-106-006
Revised 15-Oct-07
NG, NG-Dimethyl-L-arginine . dihydrochloride
SYNONYMS
H-Arg(di-Me)-OH . 2HCl (asymmetrical)
ADMA . 2HCl
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-106-006-M005
5 mg
33.00 USD
ALX-106-006-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
8
H
18
N
4
O
2
. 2 HCl . H
2
O
MW:
202.2 . 73.0 . 18.0
PURITY:
≥97%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 4 months when stored at -20°C.
HANDLING:
Hygroscopic.
Product Description
Endogenous nitric oxide synthase (NOS) inhibitor.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure:
P. Vallance, et al.; Lancet
339
, 572 (1992), and references cited therein.
Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-008
Revised 23-Feb-06
NG, N'G-Dimethyl-L-arginine . dihydrochloride
SYNONYMS
SDMA . 2HCl
H-Arg(di-Me)-OH . 2HCl (symmetrical)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-106-008-M005
5 mg
33.00 USD
ALX-106-008-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
8
H
18
N
4
O
2
. 2HCl
MW:
202.2 . 73.0
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Has shown
not
to inhibit nitric oxide synthesis, both
in vitro
and
in vivo
.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure:
P. Vallance, et al.; Lancet
339
, 572 (1992), and references cited therein.
Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-007
Revised 03-Feb-05
NG, N'G-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
SYNONYMS
SDMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (symmetrical)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-106-007-M005
5 mg
23.00 USD
ALX-106-007-M025
25 mg
55.00 USD
Product Specification
FORMULA:
C
8
H
18
N
4
O
2
. 2C
12
H
10
N
2
O
4
S
MW:
202.2 . 556.6
CAS NUMBER:
102783-24-4
PURITY:
≥97%
APPEARANCE:
Orange powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Has been shown
not
to inhibit nitric oxide synthesis, both
in vitro
and
in vivo
. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure:
P. Vallance, et al.; Lancet
339
, 572 (1992), and references cited therein.
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells:
J.B. Hibbs Jr., et al.; J. Immunol.
138
, 550 (1987)
Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-005
Revised 24-Feb-05
NG, NG-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
SYNONYMS
ADMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (asymmetrical)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-106-005-M005
5 mg
23.00 USD
ALX-106-005-M025
25 mg
55.00 USD
Product Specification
FORMULA:
C
8
H
18
N
4
O
2
. 2C
12
H
10
N
2
O
4
S
MW:
202.2 . 556.6
PURITY:
≥97%
APPEARANCE:
Orange powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits nitric oxide synthesis. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells:
J.B. Hibbs Jr., et al.; J. Immunol.
138
, 550 (1987)
Abstract
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure:
P. Vallance, et al.; Lancet
339
, 572 (1992), and references cited therein.
Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-350-240
Revised 05-Dec-07
Ilimaquinone
SYNONYMS
3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
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Unit Price:
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ALX-350-240-C100
100 µg
140.00 USD
Product Specification
FORMULA:
C
22
H
30
O
4
MW:
358.5
CAS NUMBER:
71678-03-0
PURITY:
≥98%
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Displays antimicrobial, anti-HIV and anti-inflammatory properties. Induces reversible breakdown of Golgi membranes. Inhibits the association of β-COP and ADP-ribosylation factor to Golgi membranes. Interacts with methylation enzymes. Shows anticancer activity.
Product Specific Literature References
R.T. Luibrand, et al.; Tetrahedron
35
, 609 (1979)
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone:
P.A. Takizawa, et al.; Cell
73
, 1079 (1993)
Abstract
Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion:
H.S. Radeke, et al.; Chem. Biol.
6
, 639 (1999)
Abstract
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport:
V. Cruciani, et al.; Exp. Cell Res.
287
, 130 (2003)
Abstract
Natural products with anti-HIV activity from marine organisms:
L.A. Tziveleka, et al.; Curr. Top. Med. Chem.
3
, 1512 (2003), Review
Abstract
Interaction of the smooth endoplasmic reticulum and mitochondria:
J.G. Goetz & I.R. Nabi; Biochem. Soc. Trans.
34
, 370 (2006), Review
Abstract
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway:
P.H. Lu, et al.; Eur. J. Pharmacol.
556
, 45 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
•
Golgi Apparatus
•
ADP Ribosylation Factor [ARF] / Related Products
•
Natural Products - Chemopreventive Agents
•
Natural Products - Antiviral / anti-HIV Agents
•
PRMTs, Mono- & Dimethylarginine / Related Products
•
Marine Natural Products
ALX-106-002
Revised 03-Jun-03
D-NMMA . monoacetate
SYNONYMS
N
G
-Monomethyl-D-arginine . monoacetate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-106-002-M005
5 mg
27.00 USD
ALX-106-002-M025
25 mg
100.00 USD
ALX-106-002-M100
100 mg
280.00 USD
Product Specification
FORMULA:
C
7
H
16
N
4
O
2
. CH
3
COOH
MW:
188.2 . 60.1
CAS NUMBER:
137694-75-8
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-001
Revised 30-Nov-06
L-NMMA . monoacetate
SYNONYMS
N
G
-Monomethyl-L-arginine . monoacetate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-106-001-M005
5 mg
20.00 USD
ALX-106-001-M025
25 mg
55.00 USD
ALX-106-001-M100
100 mg
180.00 USD
ALX-106-001-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
7
H
16
N
4
O
2
. CH
3
COOH
MW:
188.2 . 60.1
CAS NUMBER:
53308-83-1
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Standard inhibitor of nitric oxide synthase. Suppresses the release of nitric oxide from endothelial cells.
Product Specific Literature References
Identification of arginine as a precursor of endothelium-derived relaxing factor:
I. Sakuma, et al.; PNAS
85
, 8664 (1988)
Abstract
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation:
D.D. Rees, et al.; Br. J. Pharmacol.
96
, 418 (1989)
Abstract
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase:
M. Palacios-Callender, et al.; PNAS
101
, 7630 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-201-282
Revised 18-Mar-08
PRMT1 (human) (recombinant) (His)
SYNONYMS
Protein Arginine N-Methyltransferase 1 (human) (recombinant) (His)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
PRMTs, Mono- & Dimethylarginine / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
