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ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Adrenergics & Adrenergic Receptors / Related Products
•
Natural Products - Antitumor Reagents
•
Antitumor Agents (Anti-proliferative)
•
Alkaloids
•
Marine Natural Products
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
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ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Lipoxygenases / Related Products
•
NF-kB Pathway Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-256
Revised 07-Oct-08
(+)-Aeroplysinin-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-350-256-M001
1 mg
70.00 USD
Product Specification
FORMULA:
C
9
H
9
Br
2
NO
3
MW:
339.0
CAS NUMBER:
28656-91-9
SOURCE/HOST:
Isolated from
Aplysina aerophoba
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity.
Product Specific Literature References
Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba:
E. Fattorusso, et al.; J. Chem. Soc.
1
, 16 (1972)
Abstract
Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells:
M.H. Kreuter, et al.; Z. Naturforsch. [C]
44
, 680 (1989)
Abstract
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1:
M.H. Kreuter, et al.; Comp. Biochem. Physiol. B
97
, 151 (1990)
Abstract
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture:
M.H. Kreuter, et al.; Comp. Biochem. Physiol.
101C
, 183 (1992)
Abstract
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba:
R. Teeyapant, et al.; Z. Naturforsch. [C]
48
, 939 (1993)
Abstract
Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba:
A. Koulman, et al.; J. Nat. Prod.
59
, 591 (1996)
Abstract
Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge:
S. Rodriguez-Nieto, et al.; FASEB J.
16
, 261 (2002)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Natural Products with Antibiotic Activity
•
Natural Products - Antitumor Reagents
•
Natural Products for Angiogenesis Research
•
Marine Natural Products
ALX-630-093
Revised 23-Jul-08
Aflatoxin B1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-093-M001
1 mg
28.00 USD
ALX-630-093-M005
5 mg
110.00 USD
Product Specification
FORMULA:
C
17
H
12
O
6
MW:
312.3
CAS NUMBER:
1162-65-8
MERCK INDEX:
14:
180
RTECS:
GY1925000
SOURCE/HOST:
Isolated from
Aspergillus flavus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow powder.
SOLUBILITY:
Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.
Product Description
Naturally occuring mycotoxin produced by many species of
Aspergillus
. Metabolized by the liver to the reactive intermediate aflatoxin M
1
. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.
Product Specific Literature References
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus:
C.P. Wild, et al.; Environ. Health Perspect.
99
, 115 (1993)
Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China:
G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev.
3
, 3 (1994)
Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone:
H. Autrup, et al.; Mutagenesis
11
, 69 (1996)
Abstract
Activation and detoxication of aflatoxin B1:
F.P. Guengerich, et al.; Mutat. Res.
402
, 121 (1998), (Review)
Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1:
B.D. Roebu; J. Cell. Biochem.
91
, 242 (2004), (Review)
Abstract
Aflatoxin B1-induced DNA damage and its repair:
L. L. Bedard & T. E. Massey; Cancer Lett.
241
, 174 (2006), (Review)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-630-103
Revised 04-Sep-08
Aflatoxin B2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-103-M001
1 mg
55.00 USD
ALX-630-103-M005
5 mg
260.00 USD
Product Specification
FORMULA:
C
17
H
14
O
6
MW:
314.3
CAS NUMBER:
7220-81-7
MERCK INDEX:
14:
180
RTECS:
GY1722000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Aflatoxin B2: Chemical Identity and Biological Activity:
S.B. Chang, et al.; Science
142
, 1191 (1963)
Abstract
Accumulation of only aflatoxin B2 by a strain of Aspergillus flavus:
H.W. Schroeder & W.W. Carlton; Appl. Microbiol.
25
, 146 (1973)
Abstract
In vitro metabolism of aflatoxin B2 by animal and human liver:
B.D. Roebuck, et al.; Cancer Res.
38
, 999 (1978)
Abstract
Interaction of aflatoxin B2 with rat liver DNA and histones in vivo:
J.D. Groopman, et al.; Carcinogenesis
2
, 1371 (1981)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
•
Plant Research Reagents / Related Products
ALX-630-104
Revised 24-Sep-08
Aflatoxin G1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-104-M001
1 mg
65.00 USD
ALX-630-104-M005
5 mg
260.00 USD
Product Specification
FORMULA:
C
17
H
12
O
7
MW:
328.3
CAS NUMBER:
1165-39-5
MERCK INDEX:
14:
181
RTECS:
LV1720000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow powder.
SOLUBILITY:
Soluble in DMSO (10mg/ml), methylene chloride (5mg/ml) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Mutagenic effect of aflatoxin G1 in comparison with B1:
M.M. el-Zawahri, et al.; J. Environ. Pathol. Toxicol. Oncol.
10
, 45 (1990)
Abstract
Identification of an aflatoxin G1-serum albumin adduct and its relevance to the measurement of human exposure to aflatoxins:
G. Sabbioni & C.P. Wild; Carcinogenesis
12
, 97 (1991)
Abstract
Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro:
X.M. Sun, et al.; Biomed. Environ. Sci.
15
, 145 (2002)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Non-apoptotic Cell Death / Necrosis
•
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Plant Research Reagents / Related Products
ALX-630-106
Revised 20-Jun-08
Aflatoxin G2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-106-M001
1 mg
150.00 USD
ALX-630-106-M005
5 mg
600.00 USD
Product Specification
FORMULA:
C
17
H
14
O
7
MW:
330.3
CAS NUMBER:
7241-98-7
MERCK INDEX:
14:
181
RTECS:
LV1700000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in methylene chloride (5mg/ml), DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin.
Product Specific Literature References
Combining Ability for Resistance to Field Aflatoxin Accumulation in Maize Grain:
D.P. Gorman, et al.; Plant Breeding
109
, 296 (1992)
Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential:
J.J. Wong & D.P. Hsieh; PNAS
73
, 2241 (1976)
Abstract
General Information
Not for sale in U. S. A.
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Plant Research Reagents / Related Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
•
Non-apoptotic Cell Death / Necrosis
ALX-630-114
Revised 13-Jun-08
Aflatoxin M2
SYNONYMS
4-Hydroxyaflatoxin B
2
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
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ALX-630-114-MC01
0.1 mg
250.00 USD
Product Specification
FORMULA:
C
17
H
14
O
7
MW:
330.3
CAS NUMBER:
6885-57-0
MERCK INDEX:
14:
182
RTECS:
GY1720000
SOURCE/HOST:
Isolated from
Aspergillus flavus.
PURITY:
≥98% (HPLC, TLC)
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
Soluble in DMSO or methanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC. MAY BE CARCINOGENIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Metabolite of aflatoxin B
2
. DNA-damaging agent.
Product Specific Literature References
Milk of mammals fed an aflatoxin-containing diet.:
H. De Iongh, et al.; Nature
202
, 466 (1964)
Abstract
Isolation and structure of aflatoxins M1 and M2:
C.W. Holzapfel, et al.; Tetrahedron Lett.
25
, 2799 (1966)
Abstract
Acute toxicity of aflatoxins M1 and M2 in one-day-old ducklings:
I.F. Purchase; Food Cosmet. Toxicol.
5
, 339 (1967)
Abstract
Occurrence of aflatoxins M(1) and M(2) in milk commercialized in Ribeirão Preto-SP, Brazil:
N.S. Garrido, et al.; Food Addit. Contam.
20
, 70 (2003)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Plant Research Reagents / Related Products
•
Natural Products - Plant Research Reagents
•
Natural Products - Other Tumor Promoters
ALX-630-095
Revised 29-Oct-08
Aflatoxin M1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Mycotoxins
Ordering Information
Product Numbers:
Format:
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Quantity:
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ALX-630-095-MC01
0.1 mg
80.00 USD
Product Specification
FORMULA:
C
17
H
12
O
7
MW:
328.3
CAS NUMBER:
6795-23-9
MERCK INDEX:
14:
182
RTECS:
GY1880000
SOURCE/HOST:
Isolated from
Aspergillus flavus
.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methylene chloride (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
MAY BE CARCINOGENIC. MAY BE MUTAGENIC. VERY TOXIC.
Product Description
Potent hepatotoxic and hepatocarcinogenic mycotoxin. Hydroxylated metabolite of aflatoxin B
1
. Maximum absorbance (λ
max
) at 228, 264 and 360nm.
Product Specific Literature References
Production and characterization of monoclonal antibodies against aflatoxin M1:
N.A. Woychik, et al.; Appl. Environ. Microbiol.
48
, 1096 (1984)
