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Items 18 of 18
ALX-550-213
Revised 06-Jun-08
(±)-BAY K 8644
SYNONYMS
1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]pyridine-3-carboxylic acid methyl ester
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-550-213-M005
5 mg
80.00 USD
ALX-550-213-M025
25 mg
320.00 USD
Product Specification
FORMULA:
C
16
H
15
F
3
N
2
O
4
MW:
356.3
CAS NUMBER:
93468-89-4
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent, direct acting, voltage-sensitive Ca
2+
channel (L-type) agonist.
Product Specific Literature References
The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels:
G. Franckowiak, et al.; Eur. J. Pharmacol.
114
, 223 (1985)
Abstract
BAY-K-8644, a calcium channel agonist, induces a rise in cytoplasmic free calcium and iodide discharge in thyroid cells:
N. Takasu, et al.; BBRC
143
, 1107 (1987)
Abstract
Goldstein, et al.; Drug Dev. Res.
11
, 59 (1987)
Calcium channel ligands:
D.J. Triggle & R.A. Janis; Ann. Rev. Pharmacol. Toxicol.
27
, 347 (1987)
Abstract
1,4-Dihydropyridine activators and antagonists: structural and functional distinctions:
D.J. Triggle & D. Rompe; TIPS
10
, 507 (1989)
Abstract
ALX-430-026
Revised 12-Sep-06
Calmidazolium chloride
SYNONYMS
1-[
bis
(p-Chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl] imidazolium chloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-430-026-M010
10 mg
85.00 USD
ALX-430-026-M050
50 mg
340.00 USD
Product Specification
FORMULA:
C
31
H
23
Cl
7
N
2
O
MW:
687.7
CAS NUMBER:
57265-65-3
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in methanol, 100% ethanol, chloroform, DMSO or propylene glycol; almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Calmodulin antagonist. At least 150 times more potent than trifluoperazine (Prod. No.
ALX- 550-310
) as an inhibitor of brain calmodulin-dependent phosphodiesterase. Inhibitor of voltage-gated Ca
2+
channels. Blocks Ca
2+
-calmodulin binding to NOS.
Product Specific Literature References
Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta:
V.B. Schini & P.M. Vanhoutte; J. Pharmacol. Exp. Ther.
261
, 553 (1992)
Abstract
Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery:
S. Illiano, et al.; Br. J. Pharmacol.
107
, 387 (1992)
Abstract
The calmodulin antagonist calmidazolium stimulates release of nitric oxide in neuroblastoma N1E-115 cells:
J. Hu & E.E. el-Fakahany; Neuroreport
4
, 198 (1993)
Abstract
Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2:
K.S. Murthy & G.M. Makhlouf; J. Biol. Chem.
269
, 15977 (1994)
Abstract
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia:
Z. Lacza, et al.; Free Radic. Biol. Med.
31
, 1609 (2001)
Abstract
Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells:
E.N. Dedkova, et al.; Am. J. Physiol. Cell Physiol.
286
, C406 (2004)
Abstract
;
Full Text
Neural tube closure depends on nitric oxide synthase activity:
A. Nachmany, et al.; J. Neurochem.
96
, 247 (2006)
Abstract
Further Categories Containing This Product:
NOS Other Products
•
Ca2+ Channels (L-type)
•
Phosphodiesterases / Related Products
ALX-350-027
Revised 19-Aug-08
Calphostin C
SYNONYMS
UCN-1028C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-350-027-C100
100 µg
85.00 USD
ALX-350-027-M001
1 mg
595.00 USD
Product Specification
FORMULA:
C
44
H
38
O
14
MW:
790.8
CAS NUMBER:
121263-19-2
SOURCE/HOST:
Isolated from
Cladosporium cladosporioides
MST-FP1798.
PURITY:
≥95% (HPLC)
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for 3 months when stored at -20°C.
HANDLING:
Protect from light.
Product Description
Potent and selective inhibitor of the protein kinase C (PKC) regulatory site of diacylglycerol and phorbol esters. At higher concentrations inhibits myosin light chain kinase, cAMP-dependent protein kinase, protein kinase G and pp60v-src protein tyrosine kinase. Induces apoptotic DNA fragmentation and cell death. Kills breast cancer cells. Has antiviral potential. Inhibits cardiac L-type Ca
2+
channels.
Product Specific Literature References
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C:
E. Kobayashi, et al.; BBRC
159
, 548 (1989)
Abstract
Potent and specific inhibitors of protein kinase C of microbial origin:
T. Tamaoki and H. Nakano; Biotechnology
8
, 732 (1990)
Abstract
Inhibition of protein kinase C by calphostin C is light-dependent:
R.F. Bruns, et al.; BBRC
176
, 288 (1991)
Abstract
Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C:
R. Gopalakrishna, et al.; FEBS Lett.
314
, 149 (1992)
Abstract
Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation:
S. Svetlov and S. Nigam; Biochim. Biophys. Acta
1177
, 75 (1993)
Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C:
W.D. Jarvis, et al.; Cancer Res.
54
, 1707 (1994)
Abstract
Growth inhibition of herpes simplex virus-type 1 in calphostin C-treated astrocytes:
C.G. Castagnino, et al.; Intervirology
38
, 332 (1995)
Abstract
Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels:
H.C. Hartzell & A. Rinderknecht; Am. J. Physiol.
270
, C1293 (1996)
Abstract
Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with antileukemic activity:
C.L. Chen, et al.; Pharm. Res.
16
, 1003 (1999)
Abstract
Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization:
B. Guo, et al.; Breast Cancer Res. Treat.
82
, 125 (2003)
Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
PKA Inhibitors
•
PKC Inhibitors
•
PKG Inhibitors
•
Ca2+ Channels (L-type)
•
Natural Products - Antitumor Reagents
•
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-550-214
Revised 03-Feb-05
Diltiazem . hydrochloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
Format:
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ALX-550-214-G001
1 g
40.00 USD
ALX-550-214-G005
5 g
110.00 USD
Product Specification
FORMULA:
C
22
H
26
N
2
O
4
S . HCl
MW:
414.5 . 36.5
CAS NUMBER:
33286-22-5
MERCK INDEX:
14:
3202
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water, methanol or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibitor of L-type Ca
2+
channels. Regulates Ca
2+
release from intracellular stores in neutrophils.
Product Specific Literature References
Diltiazem. A review of its pharmacological properties and therapeutic efficacy:
M. Chaffman & R.N. Bogden; Drugs
29
, 387 (1985)
Abstract
ALX-550-268
Revised 09-Dec-04
Flunarizine . dihydrochloride
SYNONYMS
1-[bis(4-Fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
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ALX-550-268-G001
1 g
35.00 USD
Product Specification
FORMULA:
C
26
H
26
F
2
N
2
. 2HCl
MW:
404.5 . 73.0
CAS NUMBER:
30484-77-6
MERCK INDEX:
14:
4144
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
50mg/ml soluble in Chloroform:methanol (1:1).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
L-, T-, and N-type Ca
2+
channel antagonist. Peripheral and cerebral vasodilator. Also inhibits K
+
-induced catecholamine release in chromaffin cells and prevents veratridine-induced cell death in bovine chromaffin cells.
Further Categories Containing This Product:
Ca2+ Channels (N-type)
•
Ca2+ Channels (T-type)
ALX-550-229
Revised 11-Nov-05
FPL 64176
SYNONYMS
2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
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ALX-550-229-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
22
H
21
NO
3
MW:
347.4
CAS NUMBER:
120934-96-5
PURITY:
≥99%
APPEARANCE:
White to tan powder.
SOLUBILITY:
Soluble in 100% ethanol or DMSO; insoluble in aqueous solution.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic. Protect from light.
Product Description
Potent Ca
2+
channel (L-type) activator.
Product Specific Literature References
A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176:
D. Rampe & A.E. Lacerda; J. Pharmacol. Exp. Ther.
259
, 982 (1991)
Abstract
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations:
W. Zheng, et al.; Mol. Pharmacol.
40
, 734 (1991)
Abstract
Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176:
D. Rampe, et al.; J. Pharmacol. Exp. Ther.
265
, 1125 (1993)
Abstract
ALX-804-090
Revised 30-Jan-06
Monoclonal Antibody to Dihydropyrine Receptor α1 (1A)
SYNONYMS
anti-DHP Receptor α1 MAb (1A)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-804-090-R400
400 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE:
1A
ISOTYPE:
Mouse IgG1
FORMULATION:
Liquid. Contains 0.05% sodium azide.
IMMUNOGEN:
Purified rabbit muscle T-tubule DHP receptor (dihydropyridine receptor).
SPECIFICITY:
Recognizes the α1 subunit of human, mouse, rat, guinea pig and rabbit DHP receptor. Detects a band of ~200kDa by Western blot.
APPLICATION:
Immunohistochemistry (frozen sections (1:200))
Immunoprecipitation
Western Blot (1:500)
Functional Application (inhibits DHP-sensitive calcium current in certain cell lines)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-091
Revised 28-Feb-08
Monoclonal Antibody to Dihydropyrine Receptor α2 (20A)
SYNONYMS
anti-DHP Receptor α2 MAb (20A)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
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Product Numbers:
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ALX-804-091-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE:
20A
ISOTYPE:
Mouse IgG2a
FORMULATION:
Liquid. Diluted ascites containing 0.05% sodium azide.
IMMUNOGEN:
Purified rabbit DHP receptor (dihydropyridine receptor).
SPECIFICITY:
Recognizes the α2 subunit of human, mouse, rat, guinea pig and rabbit DHP receptor. Detects a band of ~220kDa (non-reducing conditions) or ~143kDa (reducing conditions) by Western blot.
APPLICATION:
Immunocytochemistry
: 1:250
Immunohistochemistry
(paraffin or frozen): 1:500. Staining of DHP in rabbit skeletal muscle results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines
Western Blot
: 1:500
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-430-143
Revised 30-Nov-06
Nemadipine-A
SYNONYMS
Diethyl-4-(2,3,4,5,6-pentafluoro)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
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ALX-430-143-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
19
H
18
F
5
NO
4
MW:
419.3
CAS NUMBER:
54280-71-6
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml), 100% ethanol (10mg/ml) or methanol (100mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Cell permeable antagonist of L-type Ca
2+
channels in
C. elegans
and vertebrates.
Product Specific Literature References
A small-molecule screen in C. elegans yields a new calcium channel antagonist:
T.C. Kwok, et al.; Nature
441
, 91 (2006)
Abstract
ALX-430-144
Revised 30-Nov-06
Nemadipine-B
SYNONYMS
Diethyl-4-(2,3-dichloro)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
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ALX-430-144-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
19
H
21
Cl
2
NO
4
MW:
398.3
CAS NUMBER:
79925-38-5
PURITY:
≥95%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Cell permeable antagonist of L-type Ca
2+
channels in
C. elegans.
Product Specific Literature References
A small-molecule screen in C. elegans yields a new calcium channel antagonist:
T.C. Kwok, et al.; Nature
441
, 91 (2006)
Abstract
ALX-550-273
Revised 08-Jun-07
Nicardipine . hydrochloride
SYNONYMS
YC-93 . HCl
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[methyl(phenylmethyl)amino]ethyl ester . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+ Channels (L-type)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-550-273-G001
1 g
30.00 USD
ALX-550-273-G005
5 g
115.00 USD
Product Specification
FORMULA:
C
26
H
29
N
3
O
6
. HCl
MW:
