• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Natural Products - Anti-inflammatory Agents
You are here: Product Lines > Natural Products / Antibiotics > Natural Products > Natural Products for Inflammation Research > Natural Products - Anti-inflammatory Agents
Toolbar - View Selection
 
 Items 40-59 of 59 Page 3 of 3 Select Page: << 1 2 3   
ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
Add to Clipboard
SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-010-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 67604-48-2
MERCK INDEX: 14: 6424
PURITY: ≥95%
APPEARANCE: Light yellow to tan powder.
SOLUBILITY: Soluble in 100% ethanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract
 
 
ALX-385-026 Revised 07-Oct-08
Nobiletin
Add to Clipboard
SYNONYMS 3’,4’,5,6,7,8-Hexamethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
CCRIS 9012
NSC 76751
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-026-M010   10 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C21H22O8
MW: 402.4
CAS NUMBER: 478-01-3
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol; sparingly soluble in water or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant and anti-inflammatory. Inhibits the phosphorylation of mitogen-activated protein kinase MEK. Suppresses the expression of matrix metalloproteinases (MMP) 1, 3 and 9, that are involved in the breakdown of the extracellular matrix during tumor metastasis. Suppresses NF-κB transcriptional activation, nitric oxide (NO) and PGE2 production, inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2) expression.
Product Specific Literature References
The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice: A. Minagawa, et al.; Jpn. J. Cancer Res. 92, 1322 (2001) Abstract
Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages: N. Lin, et al.; Biochem. Pharmacol. 65, 2065 (2003) Abstract
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo: H. Ohnishi, et al.; Cancer Sci. 95, 936 (2004) Abstract; Full Text
Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells: S.Y. Choi, et al.; J. Ethnopharmacol. 113, 149 (2007) Abstract
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells: K.L. Morley, et al.; Cancer Lett. 251, 168 (2007) Abstract
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice: A. Nakajima, et al.; J. Pharmacol. Sci. 105, 122 (2007) Abstract; Full Text
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes: T. Saito, et al.; BBRC 357, 371 (2007) Abstract
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells: M. Tang, et al.; Cancer Sci. 98, 471 (2007) Abstract
Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus: K. Matsuzaki, et al.; Eur. J. Pharmacol. 578, 194 (2008) Abstract
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells: Y. Miyata, et al.; BBRC 366, 168 (2008) Abstract
 
 
ALX-350-308 Revised 03-Apr-08
3-O-Acetyl-β-boswellic acid
Add to Clipboard
SYNONYMS AβBA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-308-M001   1 mg 45.00 USD Add To Cart
ALX-350-308-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C32H50O4
MW: 498.8
CAS NUMBER: 5968-70-7
SOURCE/HOST: Isolated from Boswellia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, dimethyl formamide, DMSO, dichloromethane, 100% ethanol or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-100 times more potent than natural boswellic acid.
Product Specific Literature References
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers: V. Sterk, et al.; Planta Med. 70, 1155 (2004) Abstract
Effects of Boswellia serrata in mouse models of chemically induced colitis: P.R. Kiela, et al.; Am. J. Physiol. Gastrointest. Liver. Physiol. 288, G798 (2005) Abstract
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Abstract; Full Text
Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid: D. Poeckel, et al.; Br. J. Pharmacol. 146, 514 (2005) Abstract
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
 
 
ALX-350-109 Revised 29-Nov-07
Panepoxydone
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-109-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
SOURCE/HOST: Isolated from Lentinus crinitus.
PURITY: >95% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Specific Literature References
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract
 
 
ALX-385-015 Revised 12-Aug-08
Peonidin chloride
Add to Clipboard
SYNONYMS 3,4',5,7-Tetrahydroxy-3'-methoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-015-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C16H13O6Cl
MW: 336.7
CAS NUMBER: 134-01-0
MERCK INDEX: 14: 7143
PURITY: ≥99% (HPLC)
APPEARANCE: Beige to reddish-brown solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and chemopreventive properties.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2: J.Y. Kwon, et al.; Ann. N. Y. Acad. Sci. 1095, 513 (2007) Abstract
 
 
ALX-385-034 Revised 07-Oct-08 New product
Pterostilbene
Add to Clipboard
SYNONYMS trans-3,5-Dimethoxy-4’-hydroxystilbene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-034-M025   25 mg 90.00 USD Add To Cart
ALX-385-034-M100   100 mg 270.00 USD Add To Cart
ALX-385-034-M500   500 mg 750.00 USD Add To Cart
Product Specification
FORMULA: C16H16O3
MW: 256.3
CAS NUMBER: 537-42-8
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown powder.
SOLUBILITY: Soluble in DMSO (20mg/ml) or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and oxygen.
HAZARD: IRRITANT.
IDENTITY: Identity determined by MS and 1H-NMR.
MELTINGPOINT: 92.7-94.6°C

Product Description
Cell permeable natural methoxylated analog of resveratrol (Prod. No. ALX-270-125). Antioxidant, antiproliferative, anti-inflammatory, anti-hyperglycemic and anti-diabetic agent. Induces apoptosis. Inhibits activator protein 1 (AP-1) and NF-κB activation. Moderately inhibits COX-1 and COX-2 (IC50=19.8μM and 83.9μM).
Product Specific Literature References
Antihyperglycemic activity of phenolics from Pterocarpus marsupium: M Manickam, et al.; J. Nat. Prod. 60, 609 (1997) Abstract
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol: A.M. Rimando, et al.; J. Agric. Food Chem. 50, 3453 (2002) Abstract
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents: M. Roberti, et al.; J. Med. Chem. 46, 3546 (2003) Abstract
Antioxidant activity of hydroxystilbene derivatives in homogeneous solution: R. Amorati, et al.; J. Org. Chem. 69, 7101 (2004) Abstract
Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma: P. Ferrer, et al.; Neoplasia 7, 37 (2005) Abstract; Full Text
Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters: A.M. Rimando, et al.; J. Agric. Food Chem. 53, 3403 (2005) Abstract
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers: S. Hougee, et al.; Planta Med. 71, 387 (2005) Abstract
Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats: L. Pari & M.A. Satheesh; Life Sci. 79, 641 (2006) Abstract
Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities: R. Mikstacka, et al.; Xenobiotica 36, 269 (2006) Abstract
The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats: M. Amarnath Satheesh & L. Pari; J. Pharm. Pharmacol. 58, 1483 (2006) Abstract
Pharmacometrics of stilbenes: seguing towards the clinic: K.A. Roupe, et al.; Curr. Clin. Pharmacol. 1, 81 (2006) Abstract
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma: P. Ferrer, et al.; J. Biol. Chem. 282, 2880 (2007) Abstract; Full Text
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats: N. Suh, et al.; Clin. Cancer Res. 13, 350 (2007) Abstract; Full Text
Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells: M.H. Pan, et al.; J. Agric. Food Chem. 55, 7777 (2007) Abstract
Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity: C.M. Remsberg, et al.; Phytother. Res. 22, 169 (2008) Abstract
Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol: Z. Pan, et al.; BMC Med. Genomics 1, 7 (2008) Abstract; Full Text
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis: M. Cichocki, et al.; Mol. Nutr. Food Res. 52, S62 (2008) Abstract
Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages: M.H. Pan, et al.; J. Agric. Food Chem. 56, 7502 (2008) Abstract
In Vitro evaluation of the cytotoxic and anti-proliferative properties of resveratrol and several of its analogs: B. Billack, et al.; Cell. Mol. Biol. Lett. Epub ahead of print, (2008) Abstract
Related Products
 
 
ALX-385-001 Revised 08-Apr-08
Quercetin . dihydrate
Add to Clipboard
SYNONYMS 3,3',4',5,7-Pentahydroxyflavone . 2H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-001-G005   5 g 15.00 USD Add To Cart
ALX-385-001-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O7 . 2H2O
MW: 302.2 . 36.0
CAS NUMBER: 6151-25-3
MERCK INDEX: 14: 8034
RTECS: LK8950000
SOURCE/HOST: Isolated from Sophora japonica L.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder with a green or brown cast.
SOLUBILITY: Soluble in 100% ethanol or 1M sodium hydroxide; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. TOXIC.

Product Description
Antioxidant flavonoid. Inhibitor of mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases. Inhibitor of protein tyrosine kinases and protein kinase C (PKC). Induces apoptosis. Blocks cells at the G0/G1 interface. Activator of human deacetylase SIRT1. Reversible inhibitor of fatty acid synthase (FAS). Inhibits the production of the inflammatory mediators nitric oxide (NO), TNF-α and IL-12 in activated macrophages.
Product Specific Literature References
Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles: D.R. Lang & E. Racker; Biochim. Biophys. Acta 333, 180 (1974)
Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase: A. Beretz, et al.; Experientia 34, 1054 (1978) Abstract
Flavonoids are selective cyclic GMP phosphodiesterase inhibitors: M. Ruckstuhl, et al.; Biochem. Pharmacol. 28, 535 (1979) Abstract
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo: Y. Graziani, et al.; Eur. J. Biochem. 135, 583 (1983) Abstract
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin: M. Gschwendt, et al.; BBRC 117, 444 (1983) Abstract
Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin: J. Levy, et al.; BBRC 123, 1227 (1984) Abstract
The phospholipid- and calcium-dependent protein kinase as a target in tumor chemotherapy: H. Grunicke, et al.; Adv. Enzyme Regul. 28, 201 (1989) Abstract
Induction of apoptosis by quercetin: involvement of heat shock protein: Y.Q. Wei, et al.; Cancer Res. 54, 4952 (1994) Abstract
Multiple effects of tyrosine kinase inhibitors on vascular smooth muscle contraction: C.M. Filipeanu, et al.; Eur. J. Pharmacol. 281, 29 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Molecular mechanisms in the antiproliferative action of quercetin: B. Csokay, et al.; Life Sci. 60, 2157 (1997) Abstract
Modulation of the heat-induced activation of mitogen-activated protein (MAP) kinase by quercetin: Y. Nagasaka & K. Nakamura; Biochem. Pharmacol. 56, 1151 (1998) Abstract
Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling: M. Richter, et al.; Nutr. Cancer 34, 88 (1999) Abstract
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line: M. Russo, et al.; FEBS Lett. 462, 322 (1999) Abstract
The effect of quercetin on induction of apoptosis: J. Rzymowska, et al.; Folia Histochem. Cytobiol. 37, 125 (1999) Abstract
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res. 43, 257 (2001) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003)
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li and W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages: Y.K. Rao, et al.; Biol. Pharm. Bull. 28, 912 (2005) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Onions: a source of unique dietary flavonoids: R. Slimestad, et al.; J. Agric. Food Chem. 55, 10067 (2007) Abstract
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
Add to Clipboard
SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.