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Antiviral Agents / Related Products
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ALX-380-205 Revised 08-Apr-08
RK-682
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SYNONYMS 3-Hexadecanoyl-5-hydroxymethyl-tetronic acid
TAN 1364B
CI 010
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-205-MC05   0.5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H36O5
MW: 368.5
CAS NUMBER: 154639-24-4
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5358.
PURITY: ≥95% (HPLC as Ca salt)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Tetronic acid derivative with potent activity against HIV-1 protease. Inhibits protein tyrosine phosphatase and heparanase.
Product Specific Literature References
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo) 47, 136 (1994) Abstract
The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons: S. Fujii, et al.; Neurosci. Lett. 187, 130 (1995) Abstract
RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase: T. Hamaguchi, et al.; FEBS Lett. 372, 54 (1995) Abstract; Full Text
Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition: T. Usui, et al.; Chem. Biol. 8, 1209 (2001) Abstract; Full Text
Further Categories Containing This Product:
Antibiotics - Antiviral / Anti-HIV • Protein Tyrosine Phosphatases Other Products
 
 
ALX-380-067 Revised 08-Apr-08
β-Rubromycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral / Anti-HIV
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-067-M001   1 mg 40.00 USD Add To Cart
ALX-380-067-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C27H20O12
MW: 536.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥99%
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of HIV-1 reverse transcriptase (RT). Inhibits human telomerase. Cytostatically active against different tumor cell lines.
Product Specific Literature References
The structure of rubromycin: H. Brockmann, et al.; THL 30, 3525 (1966), (Article in German) Abstract
Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102, 126 (1969) Abstract
Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma-iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103, 1709 (1970) Abstract
Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38, 20 (1990) Abstract
Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39, 5995 (2000) Abstract
Structural and Biosynthetic Investigations of the Rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000, 729 (2000)
Further Categories Containing This Product:
Telomerase / Related Products • Antibiotics - Immunomodulators • Antitumor Antibiotics • HIV / AIDS / Related Products
 
 
ALX-350-317 Revised 08-Apr-08
Tenuazonic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-350-317-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C10H15NO3
MW: 197.3
CAS NUMBER: 610-88-8
MERCK INDEX: 14: 9149
RTECS: UY7425000
SOURCE/HOST: Isolated from Alternaria sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Brown oily solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound exhibiting antitumor, antiviral and antibacterial activity. Inhibits protein synthesis by suppression at the ribosome. May act as a mycotoxin.
Product Specific Literature References
Microbial metabolites with insecticidal properties: M. Cole & G.N. Rolinson; Appl. Microbiol. 24, 660 (1972) Abstract
Microbial production of tenuazonic acid analogues: S. Gatenbeck & J. Sierankiewicz; Antimicrob. Agents Chemother. 3, 308 (1973) Abstract
Inhibition of mouse skin tumor promotion by tenuazonic acid: M. Antony, et al.; Cancer Lett. 61, 21 (1991) Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative) • Mycotoxins • Antibiotics - Antiviral / Anti-HIV
 
 
ALX-350-296 Revised 30-Jun-08
Thalassiolin B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral / anti-HIV Agents
Ordering Information
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ALX-350-296-MC05   0.5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C22H22O14S
MW: 542.5
SOURCE/HOST: Isolated from Thalassia testudinum.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to green oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of HIV cDNA integrase.
Product Specific Literature References
Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase: D.C. Rowley, et al.; Bioorg. Med. Chem. 10, 3619 (2002) Abstract
Further Categories Containing This Product:
Marine Natural Products • HIV / AIDS / Related Products
 
 
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