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Natural Products for Neurological Research
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ALX-350-352 Revised 06-Mar-08
Magnolol
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SYNONYMS 5,5’-Diallyl-2,2’-biphenyldiol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-352-M005   5 mg 55.00 USD Add To Cart
ALX-350-352-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C18H18O2
MW: 266.3
CAS NUMBER: 528-43-8
MERCK INDEX: 14: 5697
RTECS: DV5105500
SOURCE/HOST: Isolated from Magnolia officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).
Product Specific Literature References
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003) Abstract
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text
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Further Categories Containing This Product:
Natural Products for Neurological Research • NOS Inhibitors (NOS Induction & Enzyme Activity) • Anxiolytic Agents / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Natural Products with Antibiotic Activity • Natural Products - Antitumor Reagents • Natural Products - Nitric Oxide Pathway Modulators
 
 
ALX-350-353 Revised 16-Jun-08
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • MAPK Pathway Activators • Tyrosine Kinase Inhibitors • Natural Products - Protein Kinase Inhibitors • Natural Products - Antioxidants • Natural Products for Neurological Research • Natural Products - Apoptosis Inducers & Inhibitors • Analgesic / Anti-nociceptive Agents / Related Products • Phenolic Acids
 
 
ALX-350-374 Revised 10-Jul-08 New product
Thiocolchicoside
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SYNONYMS 2-Demethoxy-2-glucosidoxythiocolchicine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-374-M001   1 mg 40.00 USD Add To Cart
ALX-350-374-M005   5 mg 120.00 USD Add To Cart
ALX-350-374-M025   25 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C27H33NO10S
MW: 563.6
CAS NUMBER: 602-41-5
MERCK INDEX: 14: 9324
SOURCE/HOST: Semisynthetic.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Potent competitive antagonist of GABAAR function. Muscle relaxant. Displays anti-inflammatory and analgesic properties. Shows strong epileptogenic and convulsant activity.
Product Specific Literature References
Review of the toxicology, pharmacodynamics and pharmacokineticss of thiocolchicoside, a GABA-agonist muscle relaxant with anti-inflammatory and analgesic actions: J.M. Janbroers; Acta Ther. 13, 221 (1987)
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat: G. Sechi, et al.; Seizure 12, 508 (2003) Abstract
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system: M. Carta, et al.; Neuropharmacology 51, 805 (2006) Abstract
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes: M.P. Mascia, et al.; Eur. J. Pharmacol. 558, 37 (2007) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-380-234 Revised 08-Apr-08
Pimprinine
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SYNONYMS 5-(3-Indolyl)-2-methyloxazole
Antibiotic WS 30581C
Antibiotic APHE 3
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-380-234-M001   1 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C12H10N2O
MW: 198.2
CAS NUMBER: 13640-26-1
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5360.
PURITY: ≥95% (HPLC)
APPEARANCE: Tan powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent inhibitor of monoamine oxidase. Has antiepileptic affects. Inhibits platelet aggregation.
Product Specific Literature References
The structure and synthesis of pimprinine: B.S. Joshi, et al.; Tetrahedron 19, 1437 (1963) Abstract
Studies on new antiplatelet agents, WS-30581 A and B: K. Umehare, et al.; J. Antibiot. (Tokyo) 37, 1153 (1984) Abstract
Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity: S.R. Naik, et al.; J. Biotechnol. 88, 1 (2001) Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Alkaloids
 
 
ALX-420-023 Revised 07-Mar-07
Lobeline . hydrochloride
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SYNONYMS L-Lobeline . HCl
2-[6-(2-Hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone . HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-023-M050   50 mg 17.00 USD Add To Cart
ALX-420-023-M250   250 mg 50.00 USD Add To Cart
ALX-420-023-G001   1 g 155.00 USD Add To Cart
Product Specification
FORMULA: C22H27NO2 . HCl
MW: 337.5 . 36.5
CAS NUMBER: 134-63-4
MERCK INDEX: 14: 5551
RTECS: OJ8490100
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Neuronal nicotinic acetylcholine receptor agonist. Respiratory stimulant.
Further Categories Containing This Product:
Alkaloids • Acetylcholine Receptors (Nicotinic) / Related Products
 
 
ALX-420-042 Revised 18-Jun-08
(-)-Menthol
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SYNONYMS (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-042-M025   25 mg 30.00 USD Add To Cart
ALX-420-042-M100   100 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C10H20O
MW: 156.3
CAS NUMBER: 2216-51-5
MERCK INDEX: 14: 5837
RTECS: OT0700000
PURITY: ≥98% (sum of enantiomers, GC)
APPEARANCE: Colorless to white crystalline solid.
SOLUBILITY: Soluble in 100% ethanol or methanol (100mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Limited shelf life.
HAZARD: IRRITANT.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.
Product Specific Literature References
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002) Abstract
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004) Abstract; Full Text
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review Abstract
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006) Abstract
Bimodal action of menthol on the transient receptor potential channel TRPA1: Y. Karashima, et al.; J. Neurosci. 27, 9874 (2007) Abstract
The menthol receptor TRPM8 is the principal detector of environmental cold: D.M. Bautista, et al.; Nature 448, 204 (2007) Abstract
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Further Categories Containing This Product:
Neuroactive Agents Other Products • TRP Channels Other Products
 
 
ALX-430-152 Revised 03-Apr-08
Cannabidiol
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SYNONYMS CBD
2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-152-M001   1 mg Inquire
ALX-430-152-M005   5 mg Inquire
Product Specification
FORMULA: C21H30O2
MW: 314.5
CAS NUMBER: 13956-29-1
MERCK INDEX: 14: 1747
RTECS: VH1600000
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Non-psychotropic, anticonvulsive and neuroprotective in vivo. Shown to be a weak CB1 receptor antagonist and inhibitor of anandamide uptake (IC50=3.35mM and 27.5mM, respectively). Weak agonist of TRPV1 (EC50=3.5mM).
Product Specific Literature References
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants: A.J. Hampson, et al.; PNAS 95, 8268 (1998) Abstract; Full Text
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: A.M. Malfait, et al.; PNAS 97, 9561 (2000) Abstract; Full Text
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite: A.B. El-Remessy, et al.; Am. J. Pathol. 163, 1997 (2003) Abstract; Full Text
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines: P. Massi, et al.; J. Pharmacol. Exp. Ther. 308, 838 (2004) Abstract; Full Text
Effects of cannabidiol (CBD) on regional cerebral blood flow: J.A. Crippa, et al.; Neuropsychopharmacology 29, 417 (2004) Abstract; Full Text
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression: E.J. Carrier, et al.; PNAS 103, 7895 (2006) Abstract; Full Text
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells: E. Del Giudice, et al.; J. Leukoc. Biol. 81, 1512 (2007) Abstract; Full Text
Further Categories Containing This Product:
Anandamide Uptake Inhibitors • Cannabinoid Receptor Agonists & Antagonists / Related Products • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-430-154 Revised 03-Apr-08
Cannabigerol
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SYNONYMS CBG
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
not sold in USA
Product Specification
FORMULA: C21H32O2
MW: 316.5
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Analog of cannabidiol (Prod. No. ALX-430-152) with similar pharmacological properties.
Product Specific Literature References
Cannabigerol monomethyl ether, a new component of hemp: T. Yamauchi, et al.; Chem. Pharm. Bull 16, 1164 (1968) Abstract
In vitro metabolism of cannabigerol in several mammalian species: D.J. Harvey and N.K. Brown; Biomed. Environ. Mass Spectrom. 19, 545 (1990) Abstract
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-445-006 Revised 03-Dec-07
4α-Phorbol 12,13-didecanoate
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SYNONYMS 4α-PDD
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Phorbols / Phorbol Esters
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-445-006-M001   1 mg 35.00 USD Add To Cart
ALX-445-006-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C40H64O8
MW: 672.9
CAS NUMBER: 27536-56-7
PURITY: ≥98% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solution cannot be made in aqueous media. Compound must be dissolved in an organic solvent prior to dilution into aqueous media. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous media.
HANDLING: Protect from light.