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Immunology
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ALX-151-035 Revised 22-Jul-08
Ac-muramyl-Ala-D-Glu-amide
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SYNONYMS MDP-LD
N-Acetylmuramyl-L-alanyl-D-isoglutamine
Adjuvant Peptide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Nod-complex / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-035-M001   1 mg 35.00 USD Add To Cart
ALX-151-035-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C19H32N4O11
MW: 492.5
CAS NUMBER: 53678-77-6
SOURCE/HOST: Synthetic.
PURITY: ≥95% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Description
Specific ligand for NALP3. For inactive control compound see MDP-DD (Prod. No. ALX-151-036).
Product Specific Literature References
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives: F. Ellouz, et al.; Biochem. Biophys. Res. Commun. 59, 1317 (1974) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-151-036 Revised 17-Nov-08
Ac-muramyl-D-Ala-D-Glu-amide
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SYNONYMS MDP-DD
N-Acetylmuramyl-D-alanyl-D-isoglutamine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Nod-complex / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-036-M001   1 mg 70.00 USD Add To Cart
ALX-151-036-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C19H32N4O11
MW: 492.5
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inactive control compound for MDP-LD (Prod. No. ALX-151-035).
Product Specific Literature References
Muramyl peptides: immunomodulators, sleep factors, and vitamins: A. Adam and E. Lederer; Med. Res. Rev. 4, 111 (1984) Abstract
 
 
ALX-380-024 Revised 30-Oct-07
Actinomycin C
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SYNONYMS Cactinomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-024-M005   5 mg 40.00 USD Add To Cart
ALX-380-024-M025   25 mg 140.00 USD Add To Cart
Product Specification
CAS NUMBER: 8052-16-2
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces chrysomallus.
PURITY: ≥98%
APPEARANCE: Orange solid.
FORMULATION: Mixture of actinomycin C1(= actinomycin D) (R = R’ = D-Val)  ~3%, C2(R = D-Val, R’ = D-allo-Ile) ~45%, C3(R = R’ = D-allo-Ile) ~53%.
SOLUBILITY: Soluble in methanol. Sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic complex with antitumor activity.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
General Information
For nomenclature see S.A. Waksman, E. Katz and L.C. Vining; PNAS 44, 602 (1958).
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-082 Revised 30-Oct-07
Actinomycin C2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-082-C500   500 µg 80.00 USD Add To Cart
Product Specification
FORMULA: C63H88N12O16
MW: 1269.5
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethylacetate or cyclohexane)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces: J. Y. Nam, et al.; Bioorg. Med. Chem. Lett. 8, 2001 (1998) Abstract
Further Categories Containing This Product:
Transcription Inhibitors / Related Products
 
 
ALX-380-077 Revised 30-Oct-07
Actinomycin C3
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-077-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C64H90N12O16
MW: 1283.5
MERCK INDEX: 14: 1606
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (solvent free)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Further Categories Containing This Product:
Transcription Inhibitors / Related Products
 
 
ALX-380-009 Revised 26-Jun-08
Actinomycin D
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SYNONYMS Actinomycin IV
Actinomycin C1
Dactinomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-009-M005   5 mg 50.00 USD Add To Cart
ALX-380-009-M025   25 mg 200.00 USD Add To Cart
ALX-380-009-M100   100 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O16
MW: 1255.5
CAS NUMBER: 50-76-0
MERCK INDEX: 14: 2800
RTECS: AU1575000
SOURCE/HOST: Isolated from Streptomyces parvulus.
PURITY: ≥98%
APPEARANCE: Red shiny crystals.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Sensitive to strong acids and bases.
HANDLING: Protect from light. Hygroscopic.
HAZARD: VERY TOXIC.

Product Description
Antitumor antibiotic. DNA intercalating agent. Cytotoxic inducer of apoptosis against tumor cells. Inhibitor of RNA synthesis.

For nomenclature see S.A. Waksman, E. Katz & L.C. Vining; PNAS 44, 602 (1958)
Product Specific Literature References
Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle: J.M. Glynn, et al.; Biochem. Soc. Trans. 20, 84S (1992) Abstract
Influence of DNA base sequence on the binding energetics of actinomycin D: S.A. Bailey, et al.; Biochemistry 32, 5881 (1993) Abstract
Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice: M. Akahori, et al.; J. Surg. Res. 85, 286 (1999) Abstract
Tumor necrosis factor-alpha plus actinomycin D-induced apoptosis of L929 cells is prevented by nitric oxide: S. Hakoda, et al.; Surg. Today 29, 1059 (1999) Abstract
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells: J. Kleeff, et al.; Int. J. Cancer 86, 399 (2000) Abstract
Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity: C. Qing, et al.; Acta Pharmacol. Sin. 24, 415 (2003) Abstract; Full Text
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II: H.E. Mischo, et al.; J. Biol. Chem. 280, 9586 (2005) Abstract
Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes: I. Kalousek, et al.; Anticancer Drugs 18, 763 (2007) Abstract
Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M.J. Wang, et al.; Neurosci. Res. 59, 40 (2007) Abstract
Related Products
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers) • Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-083 Revised 30-Oct-07
Actinomycin X0β
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-083-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O17
MW: 1271.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Detemined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-084 Revised 30-Oct-07
Actinomycin X0δ
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-084-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H86N12O17
MW: 1271.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE: Red crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-080 Revised 03-Apr-08
Actinomycin X2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-080-M001   1 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H84N12O17
MW: 1269.4
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95% (solvent free)
APPEARANCE: Orange crystals.
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic. Has higher cytotoxicity toward cultured human leukemia (HL-60) cells than actinomycin D (Prod. No. ALX-380-009). Induces cell death via apoptosis.
Product Specific Literature References
Nomenclature of the Actinomycins: S.A. Waksman, et al.; PNAS 44, 602 (1958) Abstract
Correlation of actinomycin X2 to the lipid profile in static and shaken cultures of Streptomyces nasri strain YG62: M.Y. el-Naggar, et al.; Microbios. 100, 117 (1999) Abstract
Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer: K. Kurosawa, et al.; Appl. Microbiol. Biotechnol. 72, 145 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Transcription Inhibitors / Related Products
 
 
ALX-380-085 Revised 30-Oct-07
Actinomycin Z1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-085-C200   200 µg 70.00 USD Add To Cart
Product Specification
FORMULA: C62H84N12O19
MW: 1301.5
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95% (contains traces of ethyl acetate or cyclohexane)
SOLUBILITY: Soluble in methanol, acetone or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep cool and dry.
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR: Identical to standard reference.

Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry: S. Cho, et al.; Arch. Pharm. Res. 17, 424 (1994) Abstract
Further Categories Containing This Product:
Transcription Inhibitors / Related Products
 
 
ALX-260-128 Revised 03-Apr-08
Actinonin