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ALX-430-147 Revised 24-Oct-07
Virstatin
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SYNONYMS 4-(N-(1,8-Naphthalimide))-n-butyric acid
1,3-Dioxo-1H-benz[de]isoquinoline-2(3H)-butanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-147-M010   10 mg 55.00 USD Add To Cart
ALX-430-147-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C16H13NO4
MW: 283.3
CAS NUMBER: 88909-96-0
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description

Inhibits virulence regulation in V. cholerae. Prevents expression of cholera toxin and the toxin coregulated pilus (TCP) by inhibiting the transcriptional regulator ToxT. Effectively protects infant mice against TCP-dependent V. cholerae intestinal colonization in vivo. Displays little toxicity towards mammalian cells (up to 2mM for Hep2 cells).
Product Specific Literature References
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization: D.T. Hung, et al.; Science 310, 670 (2005) Abstract
Virstatin inhibits dimerization of the transcriptional activator ToxT: E. A. Shakhnovich, et al.; PNAS 104, 2372 (2007) Abstract
 
 
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