ALEXIS Biochemicals: W-7 . hydrochloride

ALX-270-153

Revised 29-Feb-08

W-7 . hydrochloride
SYNONYMS	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calmodulin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-153-M005		5 mg	20.00 USD
ALX-270-153-M025		25 mg	60.00 USD

Product Specification

FORMULA:	C₁₆H₂₁ClN₂O₂S . HCl
MW:	340.9 . 36.5
CAS NUMBER:	61714-27-0
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (warm), methanol, 100% ethanol (warm), DMSO, dimethyl formamide or ethylene glycol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by H-NMR.

Product Description

Antagonist of calmodulin, inhibiting activation of Ca²⁺/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.

Product Specific Literature References

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981) Abstract
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983) Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984) Abstract

Related Products

ALX-270-175

W-7 Isomer . hydrochloride

Further Categories Containing This Product:

Phosphodiesterases / Related Products • Myosin Light Chain Kinase Inhibitors

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