ALEXIS Biochemicals: WP1066

ALX-270-483

Revised 07-Apr-08

WP1066
SYNONYMS	3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (Apoptosis Inducers)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-483-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₁₇H₁₄BrN₃O
MW:	356.2
CAS NUMBER:	857064-38-1
PURITY:	≥95%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO (>5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.

Product Specific Literature References

A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res. 67, 9630 (2007) Abstract
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene 26, 2435 (2007) Abstract

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