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ALX-385-033 Revised 28-May-08 New product
Wogonin
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SYNONYMS 5,7-Dihydroxy-8-methoxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-033-M005   5 mg 60.00 USD Add To Cart
ALX-385-033-M025   25 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C16H12O5
MW: 284.3
CAS NUMBER: 632-85-9
RTECS: LK8331000
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description

Cell permeable and orally available flavonoid. Induces apoptosis in tumor cells but not in healthy cells by increasing peroxide production. Displays anti-inflammatory properties. Suppresses the release of nitric oxide (NO) by inducible nitric oxide synthase (iNOS; NOS II), PGE2 by cyclooxygenase-2 (COX-2), proinflammatory cytokines, MCP-1 gene expression and NF-κB activation. Antioxidant.

Product Specific Literature References
The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin: C.C. Lin & D.E. Shieh; Am. J. Chin. Med. 24, 31 (1996) Abstract
Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol. 84, 288 (1999) Abstract
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines: S. Ikemoto, et al.; Urology 55, 951 (2000) Abstract
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res. 20, 2861 (2000) Abstract
Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol. 60, 507 (2001) Abstract; Full Text
Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells: Y.S. Chi, et al.; Biochem. Pharmacol. 61, 1195 (2001) Abstract
The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production: H. Kim, et al.; Neurosci. Lett. 309, 67 (2001) Abstract
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1: Y.C. Chen, et al.; Arch. Toxicol. 76, 351 (2002) Abstract
Anti-inflammatory plant flavonoids and cellular action mechanisms

: H.P. Kim, et al.; J. Pharmacol. Sci. 96, 229 (2004) Abstract; Full Text
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells: S.O. Lee, et al.; BBRC 351, 118 (2006) Abstract
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis: S.C. Fas, et al.; Blood 108, 3700 (2006) Abstract; Full Text
Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action

: R. Enomoto, et al.; J. Pharmacol. Sci. 104, 355 (2007) Abstract; Full Text
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC{gamma}1- and Ca2+-dependent apoptosis: S. Baumann, et al.; Blood 111, 2354 (2007) Abstract

 
 

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