ALEXIS Biochemicals: XEDAR (human):Fc (human) (recombinant)

ALX-522-049

Revised 18-Jul-06

XEDAR (human):Fc (human) (recombinant)
SYNONYMS	X-linked Ectodysplasin-A2 Receptor (human):Fc (human) (recombinant) EDA-A2 Receptor (human):Fc (human) (recombinant) EDA2R (human):Fc (human) (recombinant) TNFRSF27 (human):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	EDA & EDAR, Troy / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-049-C050		50 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
MW:	~47kDa (SDS-PAGE).
SOURCE/HOST:	Produced in HEK 293 cells. The cysteine-rich domain of human XEDAR (X-linked ectodysplasin-A2 receptor) (aa 1-133) is fused to the Fc portion of human IgG1.
CONCENTRATION:	1mg/ml after reconstitution
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds human EDA-A2 (ectodysplasin-A2).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.

Product Specific Literature References

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9HAV5: XEDAR (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors: M. Yan, et al.; Science 290, 523 (2000) Abstract