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ALX-420-025 Revised 26-Jun-08
YC-1
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SYNONYMS 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-025-M001   1 mg 20.00 USD Add To Cart
ALX-420-025-M005   5 mg 65.00 USD Add To Cart
ALX-420-025-M025   25 mg 260.00 USD Add To Cart
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Product Specification
FORMULA: C19H16N2O2
MW: 304.4
CAS NUMBER: 170632-47-0
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in DMSO, methanol or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Nitric oxide (NO) independent, superoxide-sensitive stimulator of soluble guanylyl cyclase (sGC). Inhibits platelet adhesion to collagen. Non-specific phosphodiesterase inhibitor. YC-1 inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth.
Inhibits Na+ channel.
Binds to [3H]BW202W92.

Product Specific Literature References
YC-1, a novel activator of platelet guanylate cyclase: F.N. Ko, et al.; Blood 84, 4226 (1994) Abstract
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase: C.C. Wu, et al.; Br. J. Pharmacol 116, 1973 (1995) Abstract
Effect of YC-1, an NO-independent, superoxide-sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators: A. Mülsch, et al.; Br. J. Pharmacol. 120, 681 (1997) Abstract
Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat: J.W. Wegener, et al.; Br. J. Pharmacol. 122, 1523 (1997) Abstract
Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle: J.W. Wegener & H. Nawrath; Eur. J. Pharmacol. 323, 89 (1997) Abstract
Inhibition of platelet adhesion to collagen by cGMP-elevating agents: C.-C. Wu, et al.; BBRC 231, 412 (1997) Abstract
Mechanism of YC-1-induced activation of soluble guanylyl cyclase: A. Friebe & D. Koesling; Mol. Pharmacol. 53, 123 (1998) Abstract; Full Text
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum: K. Hebeiss & H. Kilbinger; Neuroscience 82, 623 (1998) Abstract
Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide: J.R. Stone & M.A. Marletta; Chem. Biol. 5, 255 (1998) Abstract
Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line: E.M. Becker, et al.; Nitric Oxide 3, 55 (1999) Abstract
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition: G. Garthwaite, et al.; Mol. Pharmacol. 61, 97 (2002) Abstract
A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain: D. R. Riddall, et al.; Mol. Pharmacol. 69, 278 (2006) Abstract
General Literature References
[1] YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1: E.J. Yeo, et al.; J. Natl. Cancer Inst. 95, 516 (2003) Abstract
 
 

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