ALEXIS Biochemicals: (Z)-4-Hydroxytamoxifen

ALX-550-361

Revised 18-Dec-07

(Z)-4-Hydroxytamoxifen
SYNONYMS	(Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (Hormone-related)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-361-M001		1 mg	40.00 USD
ALX-550-361-M005		5 mg	145.00 USD

Product Specification

FORMULA:	C₂₆H₂₉NO₂
MW:	387.5
CAS NUMBER:	68047-06-3, 65213-48-1
PURITY:	≥98% (Z-isomer)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	MAY BE CARCINOGENIC. TOXIC.

Product Description

Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.

Product Specific Literature References

The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990) Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990) Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993) Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994) Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999) Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999) Abstract

Further Categories Containing This Product:

Lipid Peroxidation • Estrogen & Estrogen Receptors / Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products

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