ALEXIS Biochemicals: Z-IE(OMe)TD(OMe)-FMK

ALX-260-073

Revised 20-Aug-07

Z-IE(OMe)TD(OMe)-FMK
SYNONYMS	Caspase-8 Inhibitor (Fluoromethylketone) Granzyme B Inhibitor (Fluoromethylketone)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-073-M001		1 mg	220.00 USD
ALX-260-073-M005		5 mg	660.00 USD

Product Specification

SEQUENCE:	Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
FORMULA:	C₃₀H₄₃FN₄O₁₁
MW:	654.7
PURITY:	≥90% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Store stock solutions in aliquots at -20°C.
HANDLING:	Packaged under inert gas.

Product Description

Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.

Product Specific Literature References

Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry 37, 16934 (1998) Abstract
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem. 273, 4345 (1998) Abstract; Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett. 425, 61 (1998) Abstract
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood 94, 291 (1999) Abstract; Full Text
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC 277, 311 (2000) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.

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