ALEXIS Biochemicals: Z-LEVD-FMK (Ready-to-Use)

ALX-260-142

Revised 04-Jan-06

Z-LEVD-FMK (Ready-to-Use)
SYNONYMS	Caspase-4 Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-142-R100	2mM	100 µl	161.00 USD
ALX-260-142-R020	10mM	20 µl	161.00 USD

Product Specification

SEQUENCE:	Z-Leu-Glu-Val-Asp-fluoromethylketone
MW:	652.0
PURITY:	≥95% (HPLC)
FORMULATION:	Liquid. In DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Irreversible, cell permeable inhibitor of caspase-4. Inhibits also caspase-5.

Product Specific Literature References

Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase: E.L. Meyer, et al.; J. Biol. Chem. 278, 23786 (2003) Abstract; Full Text
Keratin 8/18 breakdown and reorganization during apoptosis: B. Schutte, et al.; Exp. Cell Res. 297, 11 (2004) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.

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