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ALX-260-020 Revised 03-Sep-08
Z-VAD-FMK
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SYNONYMS Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-020-M001   1 mg 97.00 USD Add To Cart
ALX-260-020-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Val-Ala-DL-Asp-fluoromethylketone
FORMULA: C21H28FN3O7
MW: 453.5
PEPTIDE CONTENT: 77-97%
PURITY: ≥92% (HPLC)
APPEARANCE: White to yellowish powder.
SOLUBILITY: Soluble in DMSO or acetonitrile (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only the amount needed at one time because of the possibility of decomposition in solution.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells: H. Zhu, et al.; FEBS Lett. 374, 303 (1995) Abstract
Neuroprotection by a caspase inhibitor in acute bacterial meningitis: J.S. Braun, et al.; Nat. Med. 5, 298 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Can be used as a broad spectrum caspase inhibitor. Prepare a 10mM stock solution of the caspase inhibitor in high quality DMSO. Add 2µl of this stock solution to 1ml of culture medium containing cells to give 20µM final concentration. Effective final concentrations are estimated to be 5-20 µM. If a particular caspase inhibitor is applied at higher concentrations specificity for an individual caspase or even for the caspase family (> 100µM) might be compromised. DMSO concentration above 0.2% may cause cellular toxicity thus masking the effect of the caspase inhibitor. For in vivo experiments extending for 12 to 48 hours, fresh inhibitor may have to be added (injected) due to inactivation by reaction with cysteine protease.
 
 
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